LOCUS       SIU02417.1               626 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 possible
            hydrolase protein.
ACCESSION   LT708304-3831
PROTEIN_ID  SIU02417.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3788C"
                     /note="Mb3788c, -, len: 626 aa. Equivalent to Rv3762c,
                     len: 626 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 626 aa overlap). Possible hydrolase (EC
                     3.-.-.-), highly similar to hypothetical proteins and
                     beta-lactamases (EC 3.5.2.6) e.g. Q9RL04|SC5G9.23
                     HYPOTHETICAL 70.3 KDA PROTEIN from Streptomyces coelicolor
                     (648 aa), FASTA scores: opt: 2088, E(): 3.7e-124, (52.9%
                     identity in 624 aa overlap); P32717|YJCS_ECOLI|B4083
                     HYPOTHETICAL 73.2 KDA PROTEIN from Escherichia coli strain
                     K12 (661 aa), FASTA scores: opt: 1911, E(): 5.7e-113,
                     (46.9% identity in 631 aa overlap); Q9A824|CC1540
                     METALLO-BETA-LACTAMASE FAMILY PROTEIN from Caulobacter
                     crescentus (647 aa), FASTA scores: opt: 1891, E(): 1e-111,
                     (48.55% identity in 628 aa overlap); Q08347|YOL164W
                     CHROMOSOME XV READING FRAME ORF from Saccharomyces
                     cerevisiae (Baker's yeast) (646 aa) FASTA scores: opt:
                     1829, E(): 8.4e-108, (45.7% identity in 615 aa overlap);
                     Q9I5I9|PA0740 PROBABLE BETA-LACTAMASE from Pseudomonas
                     aeruginosa (658 aa), FASTA scores: opt: 1699, E():
                     1.4e-99, (43.15% identity in 630 aa overlap); Q52556|SDSA
                     ALKYL SULFATASE (protein involved in the degradation of
                     sulfate esters of long-chain primaryal cohols e.g. SDS
                     sodium dodecyl sulfate) from Pseudomonas sp (528 aa),
                     FASTA scores: opt: 841, E(): 1.7e-45, (33.7% identity in
                     534 aa overlap); etc. N-terminual end also highly similar
                     to Q48790|SEPA SEPA PROTEIN (protein implicated in cell
                     separation) from Listeria monocytogenes (391 aa), FASTA
                     scores: opt: 1256, E(): 8.3e-72, (49.6% identity in 363 aa
                     overlap). Also slight similarity to
                     P96253|Rv0407|MTCY22G10.03 HYPOTHETICAL 37.0 KDA PROTEIN
                     from Mycobacterium tuberculosis (336 aa). Protein product
                     from Mb3788c detected using SWATH mass spectrometry.
                     Mb3788c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y554"
                     /db_xref="InterPro:IPR001279"
                     /db_xref="InterPro:IPR029228"
                     /db_xref="InterPro:IPR029229"
                     /db_xref="InterPro:IPR036527"
                     /db_xref="InterPro:IPR036866"
                     /db_xref="InterPro:IPR038536"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y554"
BEGIN
        1 MPMEHKPPTA VIQAAHGEHS LPLHDTTDFD DADRGFIAAL SPCVIKAADG RVVWDNDAYS
       61 FLDGAAPTSV HPSLWRQSQL TAKQGLYQVV PGIYQVRGFD ISNISFVEGD TGLIVIDPLV
      121 STEVAAAALD LYRAHRGADR PVVAVIYTHS HVDHFGGVLG GTTQADVDAG KVAVLAPEGF
      181 TAHAVQENIY AGSAMMRRAG YMYGTVLARG LRGHVGCGLG QTLSTGEVSL VVPTVDITET
      241 GETHTIDGVE IEFQMAPGTE APAEMHFYFP RFRALCMAEN ATHNLHNLLT LRGALVRDPR
      301 AWSGYLTEAI DTFADRTDVV FASHHWPTWG REKIVEFLSQ QRDMHSYLHD QTLRLLNQGY
      361 TGVEIAEMFQ LPPALQRAWH THGYYGSVSH NVKAIYQRYM GWFDGNPGWL WPHPPEALAP
      421 RYVDALGGID RVLELAREAF DAGDFRWAAT LLDHAVFADS EHAAARGLYA DTLEQLAYGA
      481 ECATWRNFFL TGAAELRDGN PGSSGQVPAP TFFAQLTPDQ IFDVLAISIN GPRAWDLDLA
      541 IDFTFTEPDV NYRLTLRNGV LIHRKLPADP ATANATVTVG DKVRLVAAAL GDISSPGFEV
      601 FGDRTVLQTF LSVLDRPDSA FNIVTP
//