LOCUS SIU02416.1 351 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE ACYL-COA DEHYDROGENASE FADE36 protein. ACCESSION LT708304-3830 PROTEIN_ID SIU02416.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="fadE36" /locus_tag="BQ2027_MB3787C" /note="Mb3787c, fadE36, len: 351 aa. Equivalent to Rv3761c, len: 351 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 351 aa overlap). Possible fadE36, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many conserved hypothetical proteins and showing some similarity with few acyl-CoA dehydrogenases, e.g. Q9APX7|FADE36 FADE36 PROTEIN from Pseudomonas aeruginosa (360 aa), FASTA scores: opt: 147, E(): 0.046, (26.15% identity in 214 aa overlap); part of AAB52261.2|U97002 protein similar to acyl-CoA dehydrogenases and epoxide hydrolases from Caenorhabditis elegans (985 aa), FASTA score: (31.2% identity in 324 aa overlap). C-terminal part is highly similar to Q50095|U1740AK|MLU15183_45 hypothetical protein from Mycobacterium leprae cosmid B174 (122 aa), FASTA scores: opt: 341, E(): 7.3e-15, (57.6% identity in 99 aa overlap). Contains PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. Protein product from Mb3787c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb3787c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR041726" /db_xref="UniProtKB/TrEMBL:A0A1R3Y5G9" BEGIN 1 MTSVDRLDGL DLGALDRYLR SLGIGRDGEL RGELISGGRS NLTFRVYDDA SSWLVRRPPL 61 HGLTPSAHDM AREYRVVAAL GDTPVPVART ISLCQDDSVL GAPFQVVEFV AGQVVRRRAE 121 LEALGSRSVI EGCVDALIRV LVDLHSIDPK AVGLSDFGKP DGYLERQVRR WGSQWELVRL 181 PDDHRDADIS RLHLALQQAI PQQSRTSIVH GDYRIDNTIL DTDDPCHVRA VVDWELSTLG 241 DPLSDAALMC VYRDPALDLI VHAQAAWTSP LLPAADELAD RYSLVSGQPL GHWEFYMALA 301 YFKLAIIAAG IDYRRRMSEQ AEGKDTAAES VPDVVAPLIA RGLAEIAKKS G //