LOCUS       SIU02416.1               351 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            ACYL-COA DEHYDROGENASE FADE36 protein.
ACCESSION   LT708304-3830
PROTEIN_ID  SIU02416.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="fadE36"
                     /locus_tag="BQ2027_MB3787C"
                     /note="Mb3787c, fadE36, len: 351 aa. Equivalent to
                     Rv3761c, len: 351 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (100.0% identity in 351 aa overlap).
                     Possible fadE36, acyl-CoA dehydrogenase (EC 1.3.99.-),
                     similar to many conserved hypothetical proteins and
                     showing some similarity with few acyl-CoA dehydrogenases,
                     e.g. Q9APX7|FADE36 FADE36 PROTEIN from Pseudomonas
                     aeruginosa (360 aa), FASTA scores: opt: 147, E(): 0.046,
                     (26.15% identity in 214 aa overlap); part of
                     AAB52261.2|U97002 protein similar to acyl-CoA
                     dehydrogenases and epoxide hydrolases from Caenorhabditis
                     elegans (985 aa), FASTA score: (31.2% identity in 324 aa
                     overlap). C-terminal part is highly similar to
                     Q50095|U1740AK|MLU15183_45 hypothetical protein from
                     Mycobacterium leprae cosmid B174 (122 aa), FASTA scores:
                     opt: 341, E(): 7.3e-15, (57.6% identity in 99 aa overlap).
                     Contains PS00339 Aminoacyl-transfer RNA synthetases
                     class-II signature 2. Protein product from Mb3787c
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb3787c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="InterPro:IPR002575"
                     /db_xref="InterPro:IPR011009"
                     /db_xref="InterPro:IPR041726"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y5G9"
BEGIN
        1 MTSVDRLDGL DLGALDRYLR SLGIGRDGEL RGELISGGRS NLTFRVYDDA SSWLVRRPPL
       61 HGLTPSAHDM AREYRVVAAL GDTPVPVART ISLCQDDSVL GAPFQVVEFV AGQVVRRRAE
      121 LEALGSRSVI EGCVDALIRV LVDLHSIDPK AVGLSDFGKP DGYLERQVRR WGSQWELVRL
      181 PDDHRDADIS RLHLALQQAI PQQSRTSIVH GDYRIDNTIL DTDDPCHVRA VVDWELSTLG
      241 DPLSDAALMC VYRDPALDLI VHAQAAWTSP LLPAADELAD RYSLVSGQPL GHWEFYMALA
      301 YFKLAIIAAG IDYRRRMSEQ AEGKDTAAES VPDVVAPLIA RGLAEIAKKS G
//