LOCUS SIU02413.1 376 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE OSMOPROTECTANT (GLYCINE BETAINE/CARNITINE/CHOLINE/L-PROLINE) TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER PROV protein. ACCESSION LT708304-3827 PROTEIN_ID SIU02413.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="proV" /locus_tag="BQ2027_MB3784C" /note="Mb3784c, proV, len: 376 aa. Equivalent to Rv3758c, len: 376 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 376 aa overlap). Possible proV, osmoprotectant transport ATP-binding protein ABC transporter (see citation below), highly similar to osmoprotection proteins (proV) involved in glycine betaine/L-proline/choline transport, e.g. BAB58610|Q99RI3|OPUCA|SA2237|SAV2448 GLYCINE BETAINE/CARNITINE/CHOLINE ABC TRANSPORTER (ATP-BINDING) from Staphylococcus aureus (410 aa), FASTA scores: opt: 816, E(): 8.4e-39, (39.5% identity in 362 aa overlap); O34992|OPCA_BACSU|OPUCA GLYCINE BETAINE/CARNITINE/CHOLINE TRANSPORT ATP-BINDING PROTEIN from Bacillus subtilis (380 aa), FASTA scores: opt: 807, E(): 2.5e-38, (40.55% identity in 333 aa overlap); Q45460|OPBA_BACSU|OPUBA|PROV CHOLINE TRANSPORT ATP-BINDING PROTEIN from Bacillus subtilis (381 aa), FASTA scores: opt: 801, E(): 5.6e-38, (40.65% identity in 337 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporter family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Protein product from Mb3784c detected using SWATH mass spectrometry. Mb3784c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y530" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="UniProtKB/TrEMBL:A0A1R3Y530" BEGIN 1 MICFDDVSKV YAHGATAVDR LTLEVPNGML TVFVGPSGCG KTTALRMINR MVDPTSGTIT 61 VDGTDVSTVN AVKLRLGIGY VIQNAGLMPH QRVIDNVATV PVLKGQPRRA ARKAGYEVLE 121 RVGLDPKVAT RYPAQLSGGE QQRVGVARAL AADPPILLMD EPFSAVDPVV RHELQNEILR 181 LQAELHKTIV FVTHDIDEAL KLADLVAVFA PGGALAQYDE TARLLSSPAN DFVSKFIGLG 241 RGYRWLQLFD AAGLPVRDIE QVSVNGLSDA RDRQVRDGWV LVVDGAGAPL GWIDADGRRR 301 HRGGAALSDA MTVGGSVFRP NGNLSQALDA ALSSPSGVGV AVDGGGKVIG GILAADVLAE 361 FQKGKKAGGG AKPCTT //