LOCUS       SIU02413.1               376 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            OSMOPROTECTANT (GLYCINE BETAINE/CARNITINE/CHOLINE/L-PROLINE)
            TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER PROV protein.
ACCESSION   LT708304-3827
PROTEIN_ID  SIU02413.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="proV"
                     /locus_tag="BQ2027_MB3784C"
                     /note="Mb3784c, proV, len: 376 aa. Equivalent to Rv3758c,
                     len: 376 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 376 aa overlap). Possible proV,
                     osmoprotectant transport ATP-binding protein ABC
                     transporter (see citation below), highly similar to
                     osmoprotection proteins (proV) involved in glycine
                     betaine/L-proline/choline transport, e.g.
                     BAB58610|Q99RI3|OPUCA|SA2237|SAV2448 GLYCINE
                     BETAINE/CARNITINE/CHOLINE ABC TRANSPORTER (ATP-BINDING)
                     from Staphylococcus aureus (410 aa), FASTA scores: opt:
                     816, E(): 8.4e-39, (39.5% identity in 362 aa overlap);
                     O34992|OPCA_BACSU|OPUCA GLYCINE BETAINE/CARNITINE/CHOLINE
                     TRANSPORT ATP-BINDING PROTEIN from Bacillus subtilis (380
                     aa), FASTA scores: opt: 807, E(): 2.5e-38, (40.55%
                     identity in 333 aa overlap); Q45460|OPBA_BACSU|OPUBA|PROV
                     CHOLINE TRANSPORT ATP-BINDING PROTEIN from Bacillus
                     subtilis (381 aa), FASTA scores: opt: 801, E(): 5.6e-38,
                     (40.65% identity in 337 aa overlap); etc. Contains PS00017
                     ATP/GTP-binding site motif A (P-loop) and PS00211 ABC
                     transporter family signature. BELONGS TO THE ATP-BINDING
                     TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Protein
                     product from Mb3784c detected using SWATH mass
                     spectrometry. Mb3784c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y530"
                     /db_xref="InterPro:IPR003439"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR017871"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y530"
BEGIN
        1 MICFDDVSKV YAHGATAVDR LTLEVPNGML TVFVGPSGCG KTTALRMINR MVDPTSGTIT
       61 VDGTDVSTVN AVKLRLGIGY VIQNAGLMPH QRVIDNVATV PVLKGQPRRA ARKAGYEVLE
      121 RVGLDPKVAT RYPAQLSGGE QQRVGVARAL AADPPILLMD EPFSAVDPVV RHELQNEILR
      181 LQAELHKTIV FVTHDIDEAL KLADLVAVFA PGGALAQYDE TARLLSSPAN DFVSKFIGLG
      241 RGYRWLQLFD AAGLPVRDIE QVSVNGLSDA RDRQVRDGWV LVVDGAGAPL GWIDADGRRR
      301 HRGGAALSDA MTVGGSVFRP NGNLSQALDA ALSSPSGVGV AVDGGGKVIG GILAADVLAE
      361 FQKGKKAGGG AKPCTT
//