LOCUS       SIU02397.1               131 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            OXIDOREDUCTASE protein.
ACCESSION   LT708304-3811
PROTEIN_ID  SIU02397.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3768C"
                     /note="Mb3768c, -, len: 131 aa. Equivalent to Rv3742c,
                     len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 131 aa overlap). Possible
                     oxidoreductase, probably combines with product of
                     downstream ORF MTV025.090c to form a functional
                     monooxygenase (EC 1.-.-.-), highly similar to N-terminal
                     end of various oxidoreductases e.g. Q9A588|CC2569
                     MONOOXYGENASE (FLAVIN-BINDING FAMILY) from Caulobacter
                     crescentus (498 aa), FASTA scores: opt: 170, E(): 0.00048,
                     (47.55% identity in 103 aa overlap); Q9APW3 AROMATIC-RING
                     HYROXYLASE from Pseudomonas aeruginosa (508 aa) FASTA
                     scores: opt: 160, E(): 0.0022, (50.55% identity in 87 aa
                     overlap); Q9RZT0|DRB0033 ARYLESTERASE/MONOXYGENASE from
                     Deinococcus radiodurans (833 aa), FASTA scores: opt: 153,
                     E(): 0.0097, (45.45% identity in 88 aa overlap); etc. Also
                     similar to C-terminal end of Mycobacterium tuberculosis
                     proteins (generally monooxygenases) e.g.
                     P96223|Rv3854c|MTCY01A6.14 HYPOTHETICAL 55.3 KDA PROTEIN
                     (489 aa), FASTA scores: opt: 140, E(): 0.044, (37.1%
                     identity in 132 aa overlap); O53300|Rv3083|MTV013.04
                     MONOXYGENASE (495 aa) FASTA scores: opt: 133, E(): 0.13,
                     (43.05% identity in 79 aa overlap);
                     O53762|Rv0565c|MTV039.03c PUTATIVE MONOXYGENASE (486 aa),
                     FASTA scores: opt: 110, E(): 4.1, (42.85% identity in 77
                     aa overlap); etc. Note similarity to MTCY01A6.14 and
                     MTV013.04 continue in downstream ORF (MTV025.089c) after a
                     gap of ~100 aa. Mb3768c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y538"
                     /db_xref="InterPro:IPR036188"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y538"
BEGIN
        1 MHSEQSASIE HVDVLIVGAG ISGTGAAYYL KTMQPAKTFA IVEARYPAIR SDSDLHTFSY
       61 EFKPWQHEKA TASADAIMVH RGRSLAGGDR TLRHRRTRHH ELRMVIIGSG ATAVTLVPAM
      121 AQTAGAVTMP K
//