LOCUS       SIU02390.1               454 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 putative
            triacylglycerol synthase (diacylglycerol acyltransferase)
            tgs2 protein.
ACCESSION   LT708304-3804
PROTEIN_ID  SIU02390.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="tgs2"
                     /locus_tag="BQ2027_MB3761C"
                     /note="Mb3761c, -, len: 454 aa. Equivalent to Rv3734c,
                     len: 454 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 454 aa overlap). Hypothetical protein,
                     highly similar to O69707|Y1E0_MYCTU|Rv3740c|MT3848|MTV025.
                     088c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis
                     (448 aa), FASTA scores: opt: 1917, E(): 1.3e-111, (61.4%
                     identity in 451 aa overlap); and similar to many other
                     proteins from Mycobacterium tuberculosis (strains H37Rv
                     and CDC1551) e.g. P71694|YE43_MYCTU|Rv1425|MT1468|MTCY21B4
                     .43|MTCY493.29c (459 aa), FASTA scores: opt: 824, E():
                     1.1e-43, (36.5% identity in 460 aa overlap);
                     Q50680|YM85_MYCTU|Rv2285|MT2343|MTCY339.25c (445 aa) FASTA
                     scores: opt: 766, E(): 4.1e-40, (36.4% identity in 453 aa
                     overlap); etc. Also similar to Q9RIU8|SCM11.13c
                     HYPOTHETICAL 47.1 KDA PROTEIN from Streptomyces coelicolor
                     (446 aa), FASTA scores: opt: 331, E(): 4.3e-13, (32.9%
                     identity in 468 aa overlap); and Q9X7A8|ML1244|MLCB1610.05
                     CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (491
                     aa), FASTA scores: opt: 296, E(): 7e-11, (28.35% identity
                     in 413 aa overlap). Contains PS00339 Aminoacyl-transfer
                     RNA synthetases class-II signature 2. Start site chosen by
                     homology, but may extend further upstream. Protein product
                     from Mb3761c detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb3761c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P67211"
                     /db_xref="InterPro:IPR004255"
                     /db_xref="InterPro:IPR009721"
                     /db_xref="InterPro:IPR014292"
                     /db_xref="InterPro:IPR023213"
                     /db_xref="UniProtKB/Swiss-Prot:P67211"
BEGIN
        1 MDLMMPNDSM FLFIESREHP MHVGGLSLFE PPQGAGPEFV REFTERLVAN DEFQPMFRKH
       61 PATIGGGIAR VAWAYDDDID IDYHVRRSAL PSPGRVRDLL ELTSRLHTSL LDRHRPLWEL
      121 HVVEGLNDGR FAMYTKMHHA LIDGVSAMKL AQRTLSADPD DAEVRAIWNL PPRPRTRPPS
      181 DGSSLLDALF KMAGSVVGLA PSTLKLARAA LLEQQLTLPF AAPHSMFNVK VGGARRCAAQ
      241 SWSLDRIKSV KQAAGVTVND AVLAMCAGAL RYYLIERNAL PDRPLIAMVP VSLRSKEDAD
      301 AGGNLVGSVL CNLATHVDDP AQRIQTISAS MDGNKKVLSE LPQLQVLALS ALNMAPLTLA
      361 GVPGFLSAVP PPFNIVISNV PGPVDPLYYG TARLDGSYPL SNIPDGQALN ITLVNNAGNL
      421 DFGLVGCRRS VPHLQRLLAH LESSLKDLEQ AVGI
//