LOCUS       SIU02387.1               358 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 possible
            atp-dependent dna ligase ligc (polydeoxyribonucleotide
            synthase [atp]) (polynucleotide ligase [atp]) (sealase)
            (dna repair protein) (dna joinase) protein.
ACCESSION   LT708304-3801
PROTEIN_ID  SIU02387.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="ligC"
                     /locus_tag="BQ2027_MB3758"
                     /note="Mb3758, ligC, len: 358 aa. Equivalent to Rv3731,
                     len: 358 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 358 aa overlap). Possible ligC, DNA
                     ligase ATP-dependent (EC 6.5.1.1), similar to numerous
                     archaebacterial and eukaryotic polynucleotide DNA ligases
                     e.g. Q9XAM3|SC4C6.17c from Streptomyces coelicolor (355
                     aa), FASTA scores: opt: 1429, E(): 1.7e-82, (60.4%
                     identity in 361 aa overlap); BAB54870|MLL9685 from
                     Rhizobium loti (Mesorhizobium loti) plasmid pMLb (337 aa),
                     FASTA scores: opt: 667, E(): 1.2e-34, (40.35% identity in
                     347 aa overlap); Q9HH07|DNLI_THEFM|LIG from Thermococcus
                     fumicolans (559 aa), FASTA scores: opt: 335, E(): 1.4e-13,
                     (27.25% identity in 330 aa overlap); O59288|DNLI_PYRHO
                     from Pyrococcus horikoshii (559 aa), FASTA scores: opt:
                     307, E(): 8e-12, (26.85% identity in 272 aa overlap); etc.
                     Also similar to Rv3062|MTCY22D7_19c|LIGB PROBABLE DNA
                     LIGASE from Mycobacterium tuberculosis (507 aa), FASTA
                     score: (30.3% identity in 356 aa overlap). SEEMS TO BELONG
                     TO THE ATP-DEPENDENT DNA LIGASE FAMILY. Protein product
                     from Mb3758 detected using SWATH mass spectrometry. Mb3758
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y525"
                     /db_xref="InterPro:IPR012309"
                     /db_xref="InterPro:IPR012310"
                     /db_xref="InterPro:IPR012340"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y525"
BEGIN
        1 MQLPVMPPVS PMLAKSVTAI PPDASYEPKW DGFRSICFRD GDQVELGSRN ERPMTRYFPE
       61 LVAAIRAELP HRCVIDGEII IATDHGLDFE ALQQRIHPAE SRVRMLADRT PASFIAFDLL
      121 ALGDDDYTGR PFSERRAALV DAVTGSGADA DLSIHVTPAT TDMATAQRWF SEFEGAGLDG
      181 VIAKPPHITY QPDKRVMFKI KHLRTADCVV AGYRVHKSGS DAIGSLLLGL YQEDGQLASV
      241 GVIGAFPMAE RRRLLTELQP LVTSFDDHPW NWAAHVAGQR TPRKNEFSRW NVGKDLSFVP
      301 LRPERVVEVR YDHMEGARFR HTAQFNRWRP DRDPRSCSYA QLERPLTVSL SDIVPGLR
//