LOCUS       SIU02385.1               776 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            TRANSFERASE protein.
ACCESSION   LT708304-3799
PROTEIN_ID  SIU02385.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3756"
                     /note="Mb3756, -, len: 776 aa. Equivalent to Rv3729, len:
                     776 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 776 aa overlap). Conserved hypothetical
                     protein, possible transferase (EC 2.-.-.-), similar to
                     several hypothetical proteins and various transferases
                     e.g. O26919|MTH831 MOLYBDENUM COFACTOR BIOSYNTHESIS MOAA
                     HOMOLOG from Methanobacterium thermoautotrophicum (497
                     aa), FASTA scores: opt: 697, E(): 4.8e-34, (30.7% identity
                     in 492 aa overlap); Q58036|Y619_METJA|MJ0619 HYPOTHETICAL
                     PROTEIN from Methanococcus jannaschii (506 aa), FASTA
                     scores: opt: 670, E(): 2e-32, (30.6% identity in 497 aa
                     overlap); O27968|AF2316 CONSERVED HYPOTHETICAL PROTEIN
                     from Archaeoglobus fulgidus (518 aa), FASTA scores: opt:
                     477, E(): 6.4e-21, (29.4% identity in 500 aa overlap);
                     BAB60102|TVG0985801 MOLYBDENUM COFACTOR BIOSYNTHESIS
                     PROTEIN from Thermoplasma volcanium (606 aa), FASTA
                     scores: opt: 402, E(): 2.1e-16, (28.1% identity in 509 aa
                     overlap); etc. C-terminus similar to methyltransferases
                     e.g. Q9S0N6|AVED C5-O-METHYLTRANSFERASE from Streptomyces
                     avermitilis (283 aa), FASTA scores: opt: 298, E():
                     1.9e-10, (31.5% identity in 292 aa overlap). Also similar
                     to the Mycobacterium tuberculosis proteins
                     P71673|YE05_MYCTU|Rv1405c|MT1449|MTCY21B4.22c (274 aa);
                     and Q50584|Rv1523|MTCY19G5.05c. Protein product from
                     Mb3756 detected using SWATH mass spectrometry. Mb3756
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3Y6L4"
                     /db_xref="InterPro:IPR007197"
                     /db_xref="InterPro:IPR013216"
                     /db_xref="InterPro:IPR013785"
                     /db_xref="InterPro:IPR029063"
                     /db_xref="InterPro:IPR034474"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y6L4"
BEGIN
        1 MFVEYTKSIC PVCKVVVDAQ VNIRHDKVYL RKRCREHGSF EALVYGDAQM YLESARFNKP
       61 GTFPLRFQTE VRDGCPSDCG LCPDHKQHAC LGLIEVNTHC NLDCPICFAD SGHQPDGYAI
      121 TAAQCERMLD TLVAAEGEPE VVMFSGGEPT IHKQLLEFVD AAQARPVKTI IINTNGIRLA
      181 SDRRFVDQLA TRNRPGHPVH IYLQFDGLDE ATHRRIRGHD LRDVKQRALD NCAAAGLTVS
      241 LVAAVERGLN EHELGAVIRH GMAQPGVQSV VFQPVTHAGR HVQFDPLTRL TNSDIIACIT
      301 AQLPEWFRPG DFFPVPCCFP SCRSITYLLT DGEHVVPIPR LLNVEDYLDY VSNRVIPDLA
      361 IREALENLWS ASAVPGTDTM TAQLQRATAA LNCAEGCGIN LPEALTHLTD RVFAIVIQDF
      421 QDPYTLNVKQ LMKCCVQQIT PDGRLIPFCA YNSVGYREQV REQLTGVPVP DIVPNAIPLA
      481 GLLADAPHGS KQANTGGSIA RLAGPTRGAP MALPPQQIKA CCADAYSRDI VALLLGDSFH
      541 PGGATLTRRL ADQLGLRSTG DPRRVADIAA GPGASARLLA SDYGVAVDGV DISEINVKRA
      601 QAAVAQTGLT ERVRFHLGDA ESVPLPDDTF DALVCECAFC TFPDKNAAAQ QFARILRPGG
      661 LAGITDVTVG DGGLPAELTP LAAWVACIAD ARTVTDYTDI LEGAGLRTRH IESHDESLLD
      721 MIDRIDARIT ALHVAAPEIL ADNGIRHDSV RDFTALARAA VQTGRIGYTL MIAEKP
//