LOCUS SIU02385.1 776 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE TRANSFERASE protein. ACCESSION LT708304-3799 PROTEIN_ID SIU02385.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB3756" /note="Mb3756, -, len: 776 aa. Equivalent to Rv3729, len: 776 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 776 aa overlap). Conserved hypothetical protein, possible transferase (EC 2.-.-.-), similar to several hypothetical proteins and various transferases e.g. O26919|MTH831 MOLYBDENUM COFACTOR BIOSYNTHESIS MOAA HOMOLOG from Methanobacterium thermoautotrophicum (497 aa), FASTA scores: opt: 697, E(): 4.8e-34, (30.7% identity in 492 aa overlap); Q58036|Y619_METJA|MJ0619 HYPOTHETICAL PROTEIN from Methanococcus jannaschii (506 aa), FASTA scores: opt: 670, E(): 2e-32, (30.6% identity in 497 aa overlap); O27968|AF2316 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (518 aa), FASTA scores: opt: 477, E(): 6.4e-21, (29.4% identity in 500 aa overlap); BAB60102|TVG0985801 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN from Thermoplasma volcanium (606 aa), FASTA scores: opt: 402, E(): 2.1e-16, (28.1% identity in 509 aa overlap); etc. C-terminus similar to methyltransferases e.g. Q9S0N6|AVED C5-O-METHYLTRANSFERASE from Streptomyces avermitilis (283 aa), FASTA scores: opt: 298, E(): 1.9e-10, (31.5% identity in 292 aa overlap). Also similar to the Mycobacterium tuberculosis proteins P71673|YE05_MYCTU|Rv1405c|MT1449|MTCY21B4.22c (274 aa); and Q50584|Rv1523|MTCY19G5.05c. Protein product from Mb3756 detected using SWATH mass spectrometry. Mb3756 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:A0A1R3Y6L4" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR034474" /db_xref="UniProtKB/TrEMBL:A0A1R3Y6L4" BEGIN 1 MFVEYTKSIC PVCKVVVDAQ VNIRHDKVYL RKRCREHGSF EALVYGDAQM YLESARFNKP 61 GTFPLRFQTE VRDGCPSDCG LCPDHKQHAC LGLIEVNTHC NLDCPICFAD SGHQPDGYAI 121 TAAQCERMLD TLVAAEGEPE VVMFSGGEPT IHKQLLEFVD AAQARPVKTI IINTNGIRLA 181 SDRRFVDQLA TRNRPGHPVH IYLQFDGLDE ATHRRIRGHD LRDVKQRALD NCAAAGLTVS 241 LVAAVERGLN EHELGAVIRH GMAQPGVQSV VFQPVTHAGR HVQFDPLTRL TNSDIIACIT 301 AQLPEWFRPG DFFPVPCCFP SCRSITYLLT DGEHVVPIPR LLNVEDYLDY VSNRVIPDLA 361 IREALENLWS ASAVPGTDTM TAQLQRATAA LNCAEGCGIN LPEALTHLTD RVFAIVIQDF 421 QDPYTLNVKQ LMKCCVQQIT PDGRLIPFCA YNSVGYREQV REQLTGVPVP DIVPNAIPLA 481 GLLADAPHGS KQANTGGSIA RLAGPTRGAP MALPPQQIKA CCADAYSRDI VALLLGDSFH 541 PGGATLTRRL ADQLGLRSTG DPRRVADIAA GPGASARLLA SDYGVAVDGV DISEINVKRA 601 QAAVAQTGLT ERVRFHLGDA ESVPLPDDTF DALVCECAFC TFPDKNAAAQ QFARILRPGG 661 LAGITDVTVG DGGLPAELTP LAAWVACIAD ARTVTDYTDI LEGAGLRTRH IESHDESLLD 721 MIDRIDARIT ALHVAAPEIL ADNGIRHDSV RDFTALARAA VQTGRIGYTL MIAEKP //