LOCUS       SIU02383.1               602 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            OXIDOREDUCTASE protein.
ACCESSION   LT708304-3797
PROTEIN_ID  SIU02383.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3754"
                     /note="Mb3754, -, len: 602 aa. Equivalent to Rv3727, len:
                     602 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 602 aa overlap). Possible
                     oxidoreductase (EC 1.-.-.-), similar to several plants
                     phytoene dehydrogenases/desaturases (EC 1.3.-.-) e.g.
                     Q9HSE1|CRTI3|VNG0277G PHYTOENE DEHYDROGENASE from
                     Halobacterium sp. strain NRC-1 (541 aa), FASTA scores:
                     opt: 299, E(): 1.1e-10, (29.85% identity in 576 aa
                     overlap); Q9FZL6|CITPDS1 PHYTOENE DESATURASE from Citrus
                     unshiu (Satsuma orange) (553 aa), FASTA scores: opt: 164,
                     E(): 0.018, (24.2% identity in 434 aa overlap);
                     Q07356|CRTI_ARATH|PDS|AT4G14210|DL3145c PHYTOENE
                     DEHYDROGENASE PRECURSOR from Arabidopsis thaliana
                     (Mouse-ear cress) (566 aa), FASTA scores: opt: 163, E():
                     0.021, (23.95% identity in 434 aa overlap); etc.
                     N-terminal end similar to O69871|SC1C3.29 PUTATIVE
                     PROTOPORPHYRINOGEN OXIDASE (FRAGMENT) from Streptomyces
                     coelicolor (61 aa), FASTA scores: opt: 154, E(): 0.012,
                     (60.45% identity in 43 aa overlap). The region between aa
                     155-310 is highly similar to Q49778|B2126_C1_169 from
                     Mycobacterium leprae (159 aa), FASTA scores: opt: 437,
                     E(): 1.5e-19, (46.6% identity in 161 aa overlap). And the
                     region between aa 462-546 is highly similar to the
                     N-terminal end of Q50003|U1764T from Mycobacterium leprae
                     (155 aa), FASTA scores: opt: 277, E(): 8.3e-10, (57.65%
                     identity in 85 aa overlap). Mb3754 found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y506"
                     /db_xref="InterPro:IPR002937"
                     /db_xref="InterPro:IPR036188"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y506"
BEGIN
        1 MKPSPADTHV VIAGAGIAGL AAAMILAEAG VRVTLCEAAS EAGGKAKSLR LADGHPTEHS
       61 LRVYTDTYQT LLTLFSRIPT EHDRTMLDNL VGVSMVSATA QGVIGRIAAP VALQRRRPTF
      121 ARIIGKVVEP PRQLVRILLR GPMVIVGLAQ RGVPATDVLH YLYAHLRLLW MCRERLLAEL
      181 GDISYADYLQ LGCKSAQAQE FFSAVPRIYV AARTSAEAAA IAPIVLKGLF RLKSNCPSAL
      241 NDAKLPAIMM MDGPTSERMV DPWIRHLTRL GVDIHFNTRV GDLEFDDGRV TALISSDGRR
      301 FACDYALLAV PYLTLRELAK SAHVKRYLPQ LTQQHALALE ASNGIQCFLR DLPATWPPFI
      361 RPGVVTTHLQ SQWSLVCVLQ GEGFWKNVRL PEGTRYVLSI TWSDVETPGP VFDRPLSECT
      421 PDEILTECLT QCGLDKSNVL GWRIDHELKH LDEAEYEKVA SELPPHLVSA PARGQRMVNF
      481 SPLTVLMPGA RHRSPGICTS VPNLLLAGEV IYSPDLTLFV PTMEKAACSG YLAARQIMNM
      541 VASHAAPLRI DFRDPAPFAV LRRVDRWFWS RRRRPPDRST FATPPTAMPA PSHLTDVDRS
      601 AS
//