LOCUS       SIU02381.1               333 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 possible
            oxidoreductase protein.
ACCESSION   LT708304-3795
PROTEIN_ID  SIU02381.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3752"
                     /note="Mb3752, -, len: 333 aa. Equivalent to Rv3725, len:
                     309 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 250 aa overlap). Possible reductase
                     (EC 1.-.-.-), similar to various oxidoreductases and
                     hypothetical proteins e.g. O34285|HPNA HPNA PROTEIN from
                     Zymomonas mobilis (337 aa), FASTA scores: opt: 317, E():
                     6.1e-11, (30.5% identity in 272 aa overlap);
                     Q9SZB3|F17M5.120|AT4G33360|AAK49584 HYPOTHETICAL 37.9 KDA
                     PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (344
                     aa), FASTA scores: opt: 314, E(): 9.1e-11, (30.35%
                     identity in 267 aa overlap); AAK59445|AT4G33360 PUTATIVE
                     DIHYDROKAEMPFEROL 4-REDUCTASE from Arabidopsis thaliana
                     (Mouse-ear cress) (332 aa), FASTA scores: opt: 313, E():
                     1e-10, (30.8% identity in 263 aa overlap); Q9FSC6|CCR
                     CINNAMOYL-COA REDUCTASE (EC 1.2.1.44) from Populus
                     trichocarpa (Western balsam poplar) (338 aa), FASTA
                     scores: opt: 305, E(): 2.9e-10, (30.3% identity in 274 aa
                     overlap); Q9M631 CINNAMOYL CoA REDUCTASE from Populus
                     tremuloides (Quaking aspen) (337 aa), FASTA scores: opt:
                     291, E(): 1.8e-09, (30.15% identity in 272 aa overlap);
                     P73212|DFRA_SYNY3|LR1706 PUTATIVE
                     DIHYDROFLAVONOL-4-REDUCTASE (EC 1.1.1.219)
                     (DIHYDROKAEMPFEROL 4-REDUCTASE) from Synechocystis sp.
                     strain PCC 6803 (343 aa), FASTA scores: opt: 278, E():
                     1e-08, (29.35% identity in 259 aa overlap); etc. Also some
                     similarity to proteins from Mycobacterium tuberculosis
                     e.g. P96816|Rv0139|MTCI5.13 HYPOTHETICAL PROTEIN (340 aa)
                     FASTA scores: opt: 234, E(): 3.2e-06, (28.25% identity in
                     269 aa overlap); and O06373|galE1|Rv3634c|MTCY15C10.18
                     PROBABLE UDP-GLUCOSE 4-EPIMERASE (314 aa) (27.3% identity
                     in 194 aa overlap). REMARK-M.bovis-M.tuberculosis: In
                     Mycobacterium bovis, a single base insertion (*-a) leads
                     to a longer product with a different COOH part compared to
                     its homolog in Mycobacterium tuberculosis (333 aa versus
                     309 aa). Protein product from Mb3752 detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb3752 found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y527"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y527"
BEGIN
        1 MQNATMRVLV TGGTGFVGGW TAKAIADAGH SVRFLVRNPA RLKTSVAKLG VDVSDFAVAD
       61 ISDRDSVREA LNGCDAVVHS AALVATDPRE TSRMLSTNMA GAQNVLGQAV ELGMDPIVHV
      121 SSFTALFRPN LATLSADLPV AGGTDGYGQS KAQIEIYARG LQDAGAPVNI TYPGMVLGPP
      181 VGDQFGEAGE GVRSALWMHV IPGRGAAWLI VDVRDVAALH AALLESGRGP RRYTAGGHRI
      241 PVPELAKILG EVAGTTMLAV PVPDSALRVA GSVLDQAGPY LPFNTPFTAA GMQYYTQMPE
      301 PDDSPSEKEL GITYRDPRDT VADTVTALRG LGS
//