LOCUS SIU02378.1 435 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 Aspartate transaminase (EC protein. ACCESSION LT708304-3792 PROTEIN_ID SIU02378.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB3749C" /EC_number="2.6.1.1" /note="Mb3749c, -, len: 435 aa. Equivalent to Rv3722c, len: 435 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 435 aa overlap). Conserved hypothetical protein, equivalent to O69513|MLCB2407.14 (alias Q9CB73|ML2336, 463 aa) HYPOTHETICAL 46.8 KDA PROTEIN from Mycobacterium leprae (426 aa), FASTA scores: opt: 2505, E(): 8.3e-154, (87.25% identity in 424 aa overlap). Also highly similar to Q9RU17|DR1579 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (452 aa), FASTA scores: opt: 1162, E(): 3.1e-67, (44.8% identity in 422 aa overlap); and partially similar to Q9I371|PA1654 PROBABLE AMINOTRANSFERASE from Pseudomonas aeruginosa (388 aa) FASTA scores: opt: 162, E(): 0.0078, (25.85% identity in 348 aa overlap) and other aminotransferases. N-terminus extended since first submission (previously 408 aa). Protein product from Mb3749c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb3749c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y516" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR024551" /db_xref="UniProtKB/TrEMBL:A0A1R3Y516" BEGIN 1 MSFDSLSPQE LAALHARHQQ DYAALQGMKL ALDLTRGKPS AEQLDLSNQL LSLPGDDYRD 61 PEGTDTRNYG GQHGLPGLRA IFAELLGIAV PNLIAGNNSS LELMHDIVAF SMLYGGVDSP 121 RPWIQEQDGI KFLCPVPGYD RHFAITETMG IEMIPIPMLQ DGPDVDLIEE LVAVDPAIKG 181 MWTVPVFGNP SGVTYSWETV RRLVQMRTAA PDFRLFWDNA YAVHTLTLDF PRQVDVLGLA 241 AKAGNPNRPY VFASTSKITF AGGGVSFFGG SLGNIAWYLQ YAGKKSIGPD KVNQLRHLRF 301 FGDADGVRLH MLRHQQILAP KFALVAEVLD QRLSESKIAS WTEPKGGYFI SLDVLPGTAR 361 RTVALAKDVG IAVTEAGASF PYRKDPDDKN IRIAPSFPSV PDLRNAVDGL ATCALLAATE 421 TLLNQGLASS APNVR //