LOCUS       SIU02378.1               435 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Aspartate
            transaminase (EC protein.
ACCESSION   LT708304-3792
PROTEIN_ID  SIU02378.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3749C"
                     /EC_number="2.6.1.1"
                     /note="Mb3749c, -, len: 435 aa. Equivalent to Rv3722c,
                     len: 435 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 435 aa overlap). Conserved
                     hypothetical protein, equivalent to O69513|MLCB2407.14
                     (alias Q9CB73|ML2336, 463 aa) HYPOTHETICAL 46.8 KDA
                     PROTEIN from Mycobacterium leprae (426 aa), FASTA scores:
                     opt: 2505, E(): 8.3e-154, (87.25% identity in 424 aa
                     overlap). Also highly similar to Q9RU17|DR1579 CONSERVED
                     HYPOTHETICAL PROTEIN from Deinococcus radiodurans (452
                     aa), FASTA scores: opt: 1162, E(): 3.1e-67, (44.8%
                     identity in 422 aa overlap); and partially similar to
                     Q9I371|PA1654 PROBABLE AMINOTRANSFERASE from Pseudomonas
                     aeruginosa (388 aa) FASTA scores: opt: 162, E(): 0.0078,
                     (25.85% identity in 348 aa overlap) and other
                     aminotransferases. N-terminus extended since first
                     submission (previously 408 aa). Protein product from
                     Mb3749c detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb3749c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y516"
                     /db_xref="InterPro:IPR015421"
                     /db_xref="InterPro:IPR015422"
                     /db_xref="InterPro:IPR015424"
                     /db_xref="InterPro:IPR024551"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y516"
BEGIN
        1 MSFDSLSPQE LAALHARHQQ DYAALQGMKL ALDLTRGKPS AEQLDLSNQL LSLPGDDYRD
       61 PEGTDTRNYG GQHGLPGLRA IFAELLGIAV PNLIAGNNSS LELMHDIVAF SMLYGGVDSP
      121 RPWIQEQDGI KFLCPVPGYD RHFAITETMG IEMIPIPMLQ DGPDVDLIEE LVAVDPAIKG
      181 MWTVPVFGNP SGVTYSWETV RRLVQMRTAA PDFRLFWDNA YAVHTLTLDF PRQVDVLGLA
      241 AKAGNPNRPY VFASTSKITF AGGGVSFFGG SLGNIAWYLQ YAGKKSIGPD KVNQLRHLRF
      301 FGDADGVRLH MLRHQQILAP KFALVAEVLD QRLSESKIAS WTEPKGGYFI SLDVLPGTAR
      361 RTVALAKDVG IAVTEAGASF PYRKDPDDKN IRIAPSFPSV PDLRNAVDGL ATCALLAATE
      421 TLLNQGLASS APNVR
//