LOCUS       SIU02376.1               420 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            FATTY ACID SYNTHASE protein.
ACCESSION   LT708304-3790
PROTEIN_ID  SIU02376.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3747"
                     /note="Mb3747, -, len: 420 aa. Equivalent to Rv3720, len:
                     420 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 420 aa overlap). Possible
                     fatty-acyl-phospholipid synthase (EC 2.1.1.-), equivalent
                     to Q9CB74|ML2334 (alias O69515|MLCB2407.16c, 439 aa)
                     HYPOTHETICAL PROTEIN from Mycobacterium leprae (420 aa)
                     FASTA scores: opt: 2508, E(): 4.7e-153, (86.45% identity
                     in 420 aa overlap). Also similar (especially at the
                     C-terminus) to various fatty-acid synthases (principally
                     cyclopropane-fatty-acyl-phospholipid synthases (EC
                     2.1.1.79)) and hypothetical proteins e.g. Q9KZ58|SCE25.32c
                     PUTATIVE FATTY ACID SYNTHASE from Streptomyces coelicolor
                     (438 aa), FASTA scores: opt: 1101, E(): 5.5e-63, (46.1%
                     identity in 425 aa overlap); P31049|YLP3_PSEPU
                     HYPOTHETICAL 44.7 KDA PROTEIN from Pseudomonas putida (394
                     aa), FASTA scores: opt: 810, E(): 2.1e-44, (46.4% identity
                     in 293 aa overlap); Q9HT28|PA5546 HYPOTHETICAL PROTEIN
                     from Pseudomonas aeruginosa (394 aa), FASTA scores: opt:
                     804, E(): 5.2e-44, (40.7% identity in 371 aa overlap);
                     Q9RSD7|DR2187 PUTATIVE
                     CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE from
                     Deinococcus radiodurans (462 aa), FASTA scores: opt: 747,
                     E(): 2.6e-40, (35.95% identity in 409 aa overlap);
                     BAB50831|Q98ET6|MLL4091
                     CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE from
                     Rhizobium loti (Mesorhizobium loti) (422 aa), FASTA
                     scores: opt: 674, E(): 1.1e-35, (39.1% identity in 284 aa
                     overlap); P30010|CFA_ECOLI|CDFA|B1661
                     CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIP SYNTHASE from
                     Escherichia coli strain K12 (381 aa), FASTA scores: opt:
                     530, E(): 1.7e-26, (33.65% identity in 312 aa overlap);
                     etc. Also similar to other proteins from Mycobacterium
                     tuberculosis e.g. CMA2|Rv0503c|MTCY20G9.30c (302 aa);
                     P96911|Rv0621|MTCY20H10 (354 aa);
                     O50416|LPQD|Rv3390|MTV004.48 (236 aa); etc. Protein
                     product from Mb3747 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb3747 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y5D8"
                     /db_xref="InterPro:IPR003333"
                     /db_xref="InterPro:IPR029063"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y5D8"
BEGIN
        1 MAEILEIFTA TGQHPLKFTA YDGSTAGQDD ATLGLDLRTP RGATYLATAP GELGLARAYV
       61 SGDLQAHGVH PGDPYELLKT LTERVDFKRP SARVLANVVR SIGVEHILPI APPPQEARPR
      121 WRRMANGLLH SKTRDAEAIH HHYDVSNNFY EWVLGPSMTY TCAVFPNAEA SLEQAQENKY
      181 RLIFEKLRLE PGDRLLDVGC GWGGMVRYAA RRGVRVIGAT LSAEQAKWGQ KAVEDEGLSD
      241 LAQVRHSDYR DVAETGFDAV SSIGLTEHIG VKNYPFYFGF LKSKLRTGGL LLNHCITRHD
      301 NRSTSFAGGF TDRYVFPDGE LTGSGRITTE IQQVGLEVLH EENFRHHYAM TLRDWCGNLV
      361 EHWDDAVAEV GLPTAKVWGL YMAASRVAFE RNNLQLHHVL ATKVDPRGDD SLPLRPWWQP
//