LOCUS SIU02355.1 390 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 Pyridoxal-
phosphate-dependent protein EgtE (ergothioneine synthase)
protein.
ACCESSION LT708304-3769
PROTEIN_ID SIU02355.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/gene="egtE"
/locus_tag="BQ2027_MB3726C"
/note="Mb3726c, -, len: 390 aa. Equivalent to Rv3700c,
len: 390 aa, from Mycobacterium tuberculosis strain H37Rv,
(100.0% identity in 390 aa overlap). Conserved
hypothetical protein; could be a transferase (EC 2.-.-.-)
or a lyase (EC 4.-.-.-). Indeed, similar to various
enzymes e.g. Q53824|CAC CAPREOMYCIN ACETYLTRANSFERASE from
Streptomyces capreolus (359 aa), FASTA scores: opt: 338,
E(): 1.1e-12, (33.35% identity in 363 aa overlap);
Q9HXX3|CSD_PSEAE|PA3667 PROBABLE CYSTEINE DESULFURASE (EC
4.4.1.-) from Pseudomonas aeruginosa (401 aa) FASTA
scores: opt: 260, E(): 4.8e-08, (30.2% identity in 404 aa
overlap); Q9X815|SC6G10.30 PUTATIVE AMINOTRANSFERASE from
Streptomyces coelicolor (460 aa), FASTA scores: opt: 243,
E(): 5.4e-07, (29.15% identity in 374 aa overlap);
Q9A761|CC1865 AMINOTRANSFERASE CLASS V from Caulobacter
crescentus (379 aa), FASTA scores: opt: 234, E(): 1.6e-06,
(27.95% identity in 383 aa overlap);
O74351|NFS1_SCHPO|SPBC21D10.11c PROBABLE CYSTEINE
DESULFURASE from Schizosaccharomyces pombe (Fission yeast)
(498 aa), FASTA scores: opt: 232, E(): 2.5e-06, (29.1%
identity in 285 aa overlap); Q9RME8|NIFS NIFS PROTEIN
(CYSTEINE DESULFURASE, TRNA SPLICING PROTEIN) from
Zymomonas mobilis (370 aa), FASTA scores: opt: 230, E():
2.6e-06, (32.85% identity in 201 aa overlap); etc.
Contains PS00626 Regulator of chromosome condensation
(RCC1) signature 2. Protein product from Mb3726c detected
using shotgun mass spectrometry and SWATH mass
spectrometry. Mb3726c found to be expressed during
exponential growth in Sauton's minimal media by
RNA-sequencing."
/db_xref="GOA:A0A1R3Y6I0"
/db_xref="InterPro:IPR000192"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="InterPro:IPR027563"
/db_xref="UniProtKB/TrEMBL:A0A1R3Y6I0"
BEGIN
1 MRRSGANSPA GDSLADRWRA ARPPVAGLHL DSAACSRQSF AALDAAAQHA RHEAEVGGYV
61 AAEAAAAVLD AGRAAVAALS GLPDAEVVFT TGSLHALDLL LGSWPGENRT LACLPGEYGP
121 NLAVMAAHGF DVRPLPTLQD GRVALDDAAF MLADDPPDLV HLTVVASHRG VAQPLAMVAQ
181 LCTELKLPLV VDAAQGLGHV DCAVGADVTY ASSRKWIAGP RGVGVLAVRP ELMERLRARL
241 PAPDWMPPLT VAQQLGFGEA NVAARVGFSV ALGEHLACGP QAIRARLAEL GDIARTVLAD
301 VSGWRVVEAV DEPSAITTLA PIDGADPAAV RAWLLSQRRI VTTYAGVERA PLELPAPVLR
361 ISPHVDNTAD DLDAFAEALV AATAATSGER
//