LOCUS       SIU02347.1               330 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            CONSERVED TRANSMEMBRANE PROTEIN protein.
ACCESSION   LT708304-3761
PROTEIN_ID  SIU02347.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3719C"
                     /note="Mb3719c, -, len: 330 aa. Equivalent to Rv3694c,
                     len: 330 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 330 aa overlap). Possible conserved
                     transmembrane protein, highly similar to Q9KZM4|SCE34.01c
                     PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces
                     coelicolor (335 aa), FASTA scores: opt: 1113, E():
                     2.5e-60, (51.5% identity in 334 aa overlap); and similar
                     to Q9KEW6|BH0733 HYPOTHETICAL PROTEIN from Bacillus
                     halodurans (355 aa), FASTA scores: opt: 381, E(): 6.1e-16,
                     (24.15% identity in 331 aa overlap); Q9AAM9|CC0568
                     HYPOTHETICAL PROTEIN from Caulobacter crescentus (332 aa),
                     FASTA scores: opt: 352, E(): 3.3e-14, (30.3% identity in
                     310 aa overlap); P74166|SLR1478 HYPOTHETICAL 35.4 KDA
                     PROTEIN from Synechocystis sp. strain PCC 6803 (317 aa),
                     FASTA scores: opt: 330, E(): 6.8e-13, (25.65% identity in
                     308 aa overlap); etc. C-terminal end shows similarity to
                     O29631|AF0624|AE001061_10 CONSERVED HYPOTHETICAL PROTEIN
                     (putative nifU protein) from Archaeoglobus fulgidus (185
                     aa), FASTA scores: opt: 154, E(): 0.021, (29.0% identity
                     in 131 aa overlap). Equivalent to AAK48163 from
                     Mycobacterium tuberculosis strain CDC1551 (395 aa) but
                     shorter 65 aa. Also some similarity to MTCY428_20
                     HYPOTHETICAL 43.7 KDA PROTEIN from Mycobacterium
                     tuberculosis. Protein product from Mb3719c detected using
                     SWATH mass spectrometry. Mb3719c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y4X7"
                     /db_xref="InterPro:IPR002798"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y4X7"
BEGIN
        1 MDVDAFLLTN RGTWDRLDHL IKKRHSLSGA EIDELVELYQ RVSTHLSMLR SASSDQLMTG
       61 RLSSLVARAR SAVTGAHAPL TRTFIRFWTV SFPVVAYRTW RWWLATAVAF FAVVVLIGFW
      121 VAGSHEVQSA IGTPTEIDEL VSHDVQSYYS EHPAASFALQ VWVNNSWVAT TCIAMSVVLG
      181 LPIPLVLFDN AANVGLIAGL MFQAGKGDFL LGLLLPHGLL ELTAVFLAAA IGMRLGWSVI
      241 SAGNRPRGQV LAEQGRGVVS VAVGLVGVFL VAGLIEAVVT PSPLPTFVRI AVGIIAEAVF
      301 LSYIGYFGRR AAQAGETGDM EDAPDVVPTG
//