LOCUS SIU02347.1 330 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN protein. ACCESSION LT708304-3761 PROTEIN_ID SIU02347.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB3719C" /note="Mb3719c, -, len: 330 aa. Equivalent to Rv3694c, len: 330 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 330 aa overlap). Possible conserved transmembrane protein, highly similar to Q9KZM4|SCE34.01c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (335 aa), FASTA scores: opt: 1113, E(): 2.5e-60, (51.5% identity in 334 aa overlap); and similar to Q9KEW6|BH0733 HYPOTHETICAL PROTEIN from Bacillus halodurans (355 aa), FASTA scores: opt: 381, E(): 6.1e-16, (24.15% identity in 331 aa overlap); Q9AAM9|CC0568 HYPOTHETICAL PROTEIN from Caulobacter crescentus (332 aa), FASTA scores: opt: 352, E(): 3.3e-14, (30.3% identity in 310 aa overlap); P74166|SLR1478 HYPOTHETICAL 35.4 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (317 aa), FASTA scores: opt: 330, E(): 6.8e-13, (25.65% identity in 308 aa overlap); etc. C-terminal end shows similarity to O29631|AF0624|AE001061_10 CONSERVED HYPOTHETICAL PROTEIN (putative nifU protein) from Archaeoglobus fulgidus (185 aa), FASTA scores: opt: 154, E(): 0.021, (29.0% identity in 131 aa overlap). Equivalent to AAK48163 from Mycobacterium tuberculosis strain CDC1551 (395 aa) but shorter 65 aa. Also some similarity to MTCY428_20 HYPOTHETICAL 43.7 KDA PROTEIN from Mycobacterium tuberculosis. Protein product from Mb3719c detected using SWATH mass spectrometry. Mb3719c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y4X7" /db_xref="InterPro:IPR002798" /db_xref="UniProtKB/TrEMBL:A0A1R3Y4X7" BEGIN 1 MDVDAFLLTN RGTWDRLDHL IKKRHSLSGA EIDELVELYQ RVSTHLSMLR SASSDQLMTG 61 RLSSLVARAR SAVTGAHAPL TRTFIRFWTV SFPVVAYRTW RWWLATAVAF FAVVVLIGFW 121 VAGSHEVQSA IGTPTEIDEL VSHDVQSYYS EHPAASFALQ VWVNNSWVAT TCIAMSVVLG 181 LPIPLVLFDN AANVGLIAGL MFQAGKGDFL LGLLLPHGLL ELTAVFLAAA IGMRLGWSVI 241 SAGNRPRGQV LAEQGRGVVS VAVGLVGVFL VAGLIEAVVT PSPLPTFVRI AVGIIAEAVF 301 LSYIGYFGRR AAQAGETGDM EDAPDVVPTG //