LOCUS       SIU02345.1               358 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            methanol dehydrogenase transcriptional regulatory protein
            moxr2 protein.
ACCESSION   LT708304-3759
PROTEIN_ID  SIU02345.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="moxR2"
                     /locus_tag="BQ2027_MB3717"
                     /note="Mb3717, moxR2, len: 358 aa. Equivalent to Rv3692,
                     len: 358 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 358 aa overlap). Probable moxR2,
                     methanol dehydrogenase regulatory protein, highly similar
                     (generally longer at N-terminus) to Q9KYW3|SCE33.20
                     PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor
                     (329 aa), FASTA scores: opt: 1523, E(): 4.2e-74, (70.9%
                     identity in 330 aa overlap); Q9Z538|SC9B2.21c PUTATIVE
                     REGULATORY PROTEIN from Streptomyces coelicolor (332 aa)
                     FASTA scores: opt: 1008, E(): 1.1e-46, (50.8% identity in
                     313 aa overlap); Q9UZ67|MOXR-3|PAB0848 METHANOL
                     DEHYDROGENASE REGULATORY PROTEIN from Pyrococcus abyssi
                     (314 aa), FASTA scores: opt: 989, E(): 1.1e-45, (50.65%
                     identity in 302 aa overlap); Q9AAN1|CC0566 MOXR PROTEIN
                     from Caulobacter crescentus (323 aa), FASTA scores: opt:
                     988, E(): 1.3e-45, (52.3% identity in 306 aa overlap);
                     etc. Also similar to O53170|MTV007.26|MOXR|Rv1479 from
                     Mycobacterium tuberculosis (377 aa); and
                     O07392|AF002133_6|MOXR from Mycobacterium avium (309 aa).
                     Also high similarity with several hypothetical bacterial
                     proteins. Protein product from Mb3717 detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb3717 found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y6H5"
                     /db_xref="InterPro:IPR011703"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="InterPro:IPR041628"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y6H5"
BEGIN
        1 MTQSASNPQA PPTQTPGAEL PGYPPQAGGA PTAAPSGPHP HRAEAESARD ALLALRAEVA
       61 KAVVGQDGVI SGLVIALLCR GHVLLEGVPG VAKTLIVRAM SAALQLEFKR VQFTPDLMPG
      121 DVTGSLVYDA RTAEFVFRPG PVFTNLLLAD EINRTPPKTQ AALLEAMEER QVSVEGEPKP
      181 LPNPFIVAAT QNPIEYEGTY QLPEAQLDRF LLKLNVTLPA RDSEIAILDR HAHGFDPRDL
      241 SAINPVAGPA ELAAGREAVR HVLVANEVLG YIVDIVGATR SSPALQLGVS PRGATALLGT
      301 ARSWAWLSGR DYVTPDDVKA MARPTLRHRV MLRPEAELEG ATPDGVLDGI LASVPVPR
//