LOCUS SIU02345.1 358 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 probable methanol dehydrogenase transcriptional regulatory protein moxr2 protein. ACCESSION LT708304-3759 PROTEIN_ID SIU02345.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="moxR2" /locus_tag="BQ2027_MB3717" /note="Mb3717, moxR2, len: 358 aa. Equivalent to Rv3692, len: 358 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 358 aa overlap). Probable moxR2, methanol dehydrogenase regulatory protein, highly similar (generally longer at N-terminus) to Q9KYW3|SCE33.20 PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (329 aa), FASTA scores: opt: 1523, E(): 4.2e-74, (70.9% identity in 330 aa overlap); Q9Z538|SC9B2.21c PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (332 aa) FASTA scores: opt: 1008, E(): 1.1e-46, (50.8% identity in 313 aa overlap); Q9UZ67|MOXR-3|PAB0848 METHANOL DEHYDROGENASE REGULATORY PROTEIN from Pyrococcus abyssi (314 aa), FASTA scores: opt: 989, E(): 1.1e-45, (50.65% identity in 302 aa overlap); Q9AAN1|CC0566 MOXR PROTEIN from Caulobacter crescentus (323 aa), FASTA scores: opt: 988, E(): 1.3e-45, (52.3% identity in 306 aa overlap); etc. Also similar to O53170|MTV007.26|MOXR|Rv1479 from Mycobacterium tuberculosis (377 aa); and O07392|AF002133_6|MOXR from Mycobacterium avium (309 aa). Also high similarity with several hypothetical bacterial proteins. Protein product from Mb3717 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb3717 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y6H5" /db_xref="InterPro:IPR011703" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR041628" /db_xref="UniProtKB/TrEMBL:A0A1R3Y6H5" BEGIN 1 MTQSASNPQA PPTQTPGAEL PGYPPQAGGA PTAAPSGPHP HRAEAESARD ALLALRAEVA 61 KAVVGQDGVI SGLVIALLCR GHVLLEGVPG VAKTLIVRAM SAALQLEFKR VQFTPDLMPG 121 DVTGSLVYDA RTAEFVFRPG PVFTNLLLAD EINRTPPKTQ AALLEAMEER QVSVEGEPKP 181 LPNPFIVAAT QNPIEYEGTY QLPEAQLDRF LLKLNVTLPA RDSEIAILDR HAHGFDPRDL 241 SAINPVAGPA ELAAGREAVR HVLVANEVLG YIVDIVGATR SSPALQLGVS PRGATALLGT 301 ARSWAWLSGR DYVTPDDVKA MARPTLRHRV MLRPEAELEG ATPDGVLDGI LASVPVPR //