LOCUS SIU02338.1 476 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE CYTOCHROME P450 137 CYP137 protein. ACCESSION LT708304-3752 PROTEIN_ID SIU02338.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="cyp137" /locus_tag="BQ2027_MB3710C" /note="Mb3710c, cyp137, len: 476 aa. Equivalent to Rv3685c, len: 476 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 476 aa overlap). Probable cyp137, cytochrome P-450 (EC 1.14.-.-), similar to many e.g. Q9VXY0|C4S3_DROME|CYP4S3|CG9081 from Drosophila melanogaster (Fruit fly) (495 aa), FASTA scores: opt: 376, E(): 1.2e-15, (28.35% identity in 413 aa overlap); Q59163|CYP110A2 from Anabaena variabilis (459 aa) FASTA scores: opt: 320, E(): 3.1e-12, (31.4% identity in 411 aa overlap); O23051|C883_ARATH from Arabidopsis thaliana (Mouse-ear cress) (490 aa), FASTA scores: opt: 313, E(): 8.8e-12, (28.25% identity in 425 aa overlap); etc. Also similar to many from Mycobacterium tuberculosis e.g. O53765|C13B_MYCTU|CYP135B1|Rv0568|MT0594|MTV039.06 (472 aa), FASTA scores: opt: 920, E(): 4.6e-49, (36.25% identity in 447 aa overlap); P96813|C138_MYCTU|CYP138|Rv0136|MT0144|MTCI5.10 (441 aa) FASTA scores: opt: 886, E(): 5.3e-47, (35.5% identity in 445 aa overlap); etc. BELONGS TO THE CYTOCHROME P450 FAMILY. Protein product from Mb3710c detected using SWATH mass spectrometry. Mb3710c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y4Z7" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002401" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="UniProtKB/TrEMBL:A0A1R3Y4Z7" BEGIN 1 MVLRSLASPA ALTDPKRCAS VVGVAAFAVR REHAPDALGG PPGLPAPRGF RAAFAAAYAV 61 AYLAGGERRM LRLIRRYGPI MTMPILSLGD VAIVSDSALA KEVFTAPTDV LLGGEGVGPA 121 AAIYGSGSMF VQEEPQHLRR RKLLTPPLHG AALDRYVPII ENSTRAAMHT WPVDRPFAML 181 TVARSLMLDV IVKVIFGVDD PEEVRRLGRP FERLLNLGVS EQLTVRYALR RLGALRVWPA 241 RARANTEIDD VVMALIAQRR ADPRLGERHD VLSLLVSARG ESGEQLSDSE IRDDLITLVL 301 AGHETTATTL AWAFDLLLHH PDALRRVRAE AVGGGEAFTT AVINETLRVR PPAPLTARVA 361 AQPLTIGGYR VEAGTRIVVH IIAINRSAEV YEHPHEFRPE RFLGTRPQTY AWVPFGGGVK 421 RCLGANFSMR ELITVLHVLL REGEFTAVDD EPERIVRRSI MLVPRRGTRV RFRPAR //