LOCUS       SIU02338.1               476 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CYTOCHROME P450 137 CYP137 protein.
ACCESSION   LT708304-3752
PROTEIN_ID  SIU02338.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="cyp137"
                     /locus_tag="BQ2027_MB3710C"
                     /note="Mb3710c, cyp137, len: 476 aa. Equivalent to
                     Rv3685c, len: 476 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (99.8% identity in 476 aa overlap). Probable
                     cyp137, cytochrome P-450 (EC 1.14.-.-), similar to many
                     e.g. Q9VXY0|C4S3_DROME|CYP4S3|CG9081 from Drosophila
                     melanogaster (Fruit fly) (495 aa), FASTA scores: opt: 376,
                     E(): 1.2e-15, (28.35% identity in 413 aa overlap);
                     Q59163|CYP110A2 from Anabaena variabilis (459 aa) FASTA
                     scores: opt: 320, E(): 3.1e-12, (31.4% identity in 411 aa
                     overlap); O23051|C883_ARATH from Arabidopsis thaliana
                     (Mouse-ear cress) (490 aa), FASTA scores: opt: 313, E():
                     8.8e-12, (28.25% identity in 425 aa overlap); etc. Also
                     similar to many from Mycobacterium tuberculosis e.g.
                     O53765|C13B_MYCTU|CYP135B1|Rv0568|MT0594|MTV039.06 (472
                     aa), FASTA scores: opt: 920, E(): 4.6e-49, (36.25%
                     identity in 447 aa overlap);
                     P96813|C138_MYCTU|CYP138|Rv0136|MT0144|MTCI5.10 (441 aa)
                     FASTA scores: opt: 886, E(): 5.3e-47, (35.5% identity in
                     445 aa overlap); etc. BELONGS TO THE CYTOCHROME P450
                     FAMILY. Protein product from Mb3710c detected using SWATH
                     mass spectrometry. Mb3710c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y4Z7"
                     /db_xref="InterPro:IPR001128"
                     /db_xref="InterPro:IPR002401"
                     /db_xref="InterPro:IPR017972"
                     /db_xref="InterPro:IPR036396"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y4Z7"
BEGIN
        1 MVLRSLASPA ALTDPKRCAS VVGVAAFAVR REHAPDALGG PPGLPAPRGF RAAFAAAYAV
       61 AYLAGGERRM LRLIRRYGPI MTMPILSLGD VAIVSDSALA KEVFTAPTDV LLGGEGVGPA
      121 AAIYGSGSMF VQEEPQHLRR RKLLTPPLHG AALDRYVPII ENSTRAAMHT WPVDRPFAML
      181 TVARSLMLDV IVKVIFGVDD PEEVRRLGRP FERLLNLGVS EQLTVRYALR RLGALRVWPA
      241 RARANTEIDD VVMALIAQRR ADPRLGERHD VLSLLVSARG ESGEQLSDSE IRDDLITLVL
      301 AGHETTATTL AWAFDLLLHH PDALRRVRAE AVGGGEAFTT AVINETLRVR PPAPLTARVA
      361 AQPLTIGGYR VEAGTRIVVH IIAINRSAEV YEHPHEFRPE RFLGTRPQTY AWVPFGGGVK
      421 RCLGANFSMR ELITVLHVLL REGEFTAVDD EPERIVRRSI MLVPRRGTRV RFRPAR
//