LOCUS       SIU02334.1               118 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            transcriptional regulatory protein whib-like whib4 protein.
ACCESSION   LT708304-3748
PROTEIN_ID  SIU02334.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="whiB4"
                     /locus_tag="BQ2027_MB3706C"
                     /note="Mb3706c, whiB4, len: 118 aa. Equivalent to Rv3681c,
                     len: 118 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 118 aa overlap). Probable whiB4,
                     WhiB-like regulatory protein (see citation below), similar
                     to WhiB paralogue of Streptomyces coelicolor, wblE gene
                     product (85 aa). Equivalent to ML2307 HYPOTHETICAL PROTEIN
                     from Mycobacterium leprae (116 aa). Also highly similar to
                     Q9S2B9|SCH17.13c PUTATIVE REGULATORY PROTEIN from
                     Streptomyces coelicolor (112 aa), FASTA scores: opt: 392,
                     E(): 1e-20, (67.95% identity in 78 aa overlap);
                     Q9X951|WBLA HYPOTHETICAL 14.3 KDA PROTEIN from
                     Streptomyces coelicolor (129 aa), FASTA scores: opt: 392,
                     E(): 1.1e-20, (67.95% identity in 78 aa overlap);
                     Q9ACZ0|SCP1.161c PUTATIVE REGULATORY PROTEIN from
                     Streptomyces coelicolor (268 aa), FASTA scores: opt: 273,
                     E(): 4.4e-12, (50.0% identity in 78 aa overlap);
                     Q06387|WHIB-STV from Streptomyces griseocarneus (87 aa)
                     FASTA scores: opt: 231, E(): 1.5e-09, (43.85% identity in
                     73 aa overlap); etc. Also similar to several putative
                     regulator proteins from Mycobacterium tuberculosis e.g.
                     MTCY7D11_7; MTCY78_13; MTCY10H4_23; MTCY1A6_6; and
                     U00016_29 from M. leprae. N-terminus shortened since first
                     submission. Mb3706c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y4W3"
                     /db_xref="InterPro:IPR003482"
                     /db_xref="InterPro:IPR034768"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y4W3"
BEGIN
        1 MSGTRPAARR TNLTAAQNVV RSVDAEERIA WVSKALCRTT DPDELFVRGA AQRKAAVICR
       61 HCPVMQECAA DALDNKVEFG VWGGMTERQR RALLKQHPEV VSWSDYLEKR KRRTGTAG
//