LOCUS SIU02334.1 118 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 probable transcriptional regulatory protein whib-like whib4 protein. ACCESSION LT708304-3748 PROTEIN_ID SIU02334.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="whiB4" /locus_tag="BQ2027_MB3706C" /note="Mb3706c, whiB4, len: 118 aa. Equivalent to Rv3681c, len: 118 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 118 aa overlap). Probable whiB4, WhiB-like regulatory protein (see citation below), similar to WhiB paralogue of Streptomyces coelicolor, wblE gene product (85 aa). Equivalent to ML2307 HYPOTHETICAL PROTEIN from Mycobacterium leprae (116 aa). Also highly similar to Q9S2B9|SCH17.13c PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (112 aa), FASTA scores: opt: 392, E(): 1e-20, (67.95% identity in 78 aa overlap); Q9X951|WBLA HYPOTHETICAL 14.3 KDA PROTEIN from Streptomyces coelicolor (129 aa), FASTA scores: opt: 392, E(): 1.1e-20, (67.95% identity in 78 aa overlap); Q9ACZ0|SCP1.161c PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (268 aa), FASTA scores: opt: 273, E(): 4.4e-12, (50.0% identity in 78 aa overlap); Q06387|WHIB-STV from Streptomyces griseocarneus (87 aa) FASTA scores: opt: 231, E(): 1.5e-09, (43.85% identity in 73 aa overlap); etc. Also similar to several putative regulator proteins from Mycobacterium tuberculosis e.g. MTCY7D11_7; MTCY78_13; MTCY10H4_23; MTCY1A6_6; and U00016_29 from M. leprae. N-terminus shortened since first submission. Mb3706c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y4W3" /db_xref="InterPro:IPR003482" /db_xref="InterPro:IPR034768" /db_xref="UniProtKB/TrEMBL:A0A1R3Y4W3" BEGIN 1 MSGTRPAARR TNLTAAQNVV RSVDAEERIA WVSKALCRTT DPDELFVRGA AQRKAAVICR 61 HCPVMQECAA DALDNKVEFG VWGGMTERQR RALLKQHPEV VSWSDYLEKR KRRTGTAG //