LOCUS SIU02319.1 651 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 ACETYL- COENZYME A SYNTHETASE ACS (ACETATE--CoA LIGASE) (ACETYL- CoA SYNTHETASE) (ACETYL-CoA SYNTHASE) (ACYL-ACTIVATING ENZYME) (ACETATE THIOKINASE) (ACETYL-ACTIVATING ENZYME) (ACETATE--COENZYME A LIGASE) (ACETYL-COENZYME A SYNTHASE) protein. ACCESSION LT708304-3733 PROTEIN_ID SIU02319.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="acs" /locus_tag="BQ2027_MB3691" /note="Mb3691, acs, len: 651 aa. Equivalent to Rv3667, len: 651 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 651 aa overlap). Probable acs, acetyl-coenzyme-A synthetase (EC 6.2.1.1), similar to many e.g. Q9X928|SCH5.26 from Streptomyces coelicolor (651 aa) FASTA scores: opt: 2850, E(): 1.9e-164, (66.05% identity in 639 aa overlap); Q55404|ACSA_SYNY3|ACS|SLL0542 from Synechocystis sp. strain PCC 6803 (653 aa), FASTA scores: opt: 2342, E(): 8.8e-134, (55.15% identity in 649 aa overlap); P31638|ACSA_ALCEU|ACOE from Alcaligenes eutrophus (Ralstonia eutropha) (660 aa), FASTA scores: opt: 2181, E(): 4.6e-124, (52.05% identity in 665 aa overlap); P27550|ACSA_ECOLI|ACS|B4069 from Escherichia coli strain K12 (652 aa), FASTA scores: opt: 1625, E(): 0, (48.3% identity in 646 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. Protein product from Mb3691 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb3691 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:P59871" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR011904" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR032387" /db_xref="InterPro:IPR042099" /db_xref="UniProtKB/Swiss-Prot:P59871" BEGIN 1 MSESTPEVSS SYPPPAHFAE HANARAELYR EAEEDRLAFW AKQANRLSWT TPFTEVLDWS 61 EAPFAKWFVG GELNVAYNCV DRHVEAGHGD RVAIHWEGEP VGDRRTLTYS DLLAEVSKAA 121 NALTDLGLVA GDRVAIYLPL IPEAVIAMLA CARLGIMHSV VFGGFTAAAL QARIVDAQAK 181 LLITADGQFR RGKPSPLKAA ADEALAAIPD CSVEHVLVVR RTGIEMAWSE GRDLWWHHVV 241 GSASPAHTPE PFDSEHPLFL LYTSGTTGKP KGIMHTSGGY LTQCCYTMRT IFDVKPDSDV 301 FWCTADIGWV TGHTYGVYGP LCNGVTEVLY EGTPDTPDRH RHFQIIEKYG VTIYYTAPTL 361 IRMFMKWGRE IPDSHDLSSL RLLGSVGEPI NPEAWRWYRD VIGGGRTPLV DTWWQTETGS 421 AMISPLPGIA AAKPGSAMTP LPGISAKIVD DHGDPLPPHT EGAQHVTGYL VLDQPWPSML 481 RGIWGDPARY WHSYWSKFSD KGYYFAGDGA RIDPDGAIWV LGRIDDVMNV SGHRISTAEV 541 ESALVAHSGV AEAAVVGVTD ETTTQAICAF VVLRANYAPH DRTAEELRTE VARVISPIAR 601 PRDVHVVPEL PKTRSGKIMR RLLRDVAENR ELGDTSTLLD PTVFDAIRAA K //