LOCUS       SIU02319.1               651 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 ACETYL-
            COENZYME A SYNTHETASE ACS (ACETATE--CoA LIGASE) (ACETYL-
            CoA SYNTHETASE) (ACETYL-CoA SYNTHASE) (ACYL-ACTIVATING
            ENZYME) (ACETATE THIOKINASE) (ACETYL-ACTIVATING ENZYME)
            (ACETATE--COENZYME A LIGASE) (ACETYL-COENZYME A SYNTHASE)
            protein.
ACCESSION   LT708304-3733
PROTEIN_ID  SIU02319.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="acs"
                     /locus_tag="BQ2027_MB3691"
                     /note="Mb3691, acs, len: 651 aa. Equivalent to Rv3667,
                     len: 651 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 651 aa overlap). Probable acs,
                     acetyl-coenzyme-A synthetase (EC 6.2.1.1), similar to many
                     e.g. Q9X928|SCH5.26 from Streptomyces coelicolor (651 aa)
                     FASTA scores: opt: 2850, E(): 1.9e-164, (66.05% identity
                     in 639 aa overlap); Q55404|ACSA_SYNY3|ACS|SLL0542 from
                     Synechocystis sp. strain PCC 6803 (653 aa), FASTA scores:
                     opt: 2342, E(): 8.8e-134, (55.15% identity in 649 aa
                     overlap); P31638|ACSA_ALCEU|ACOE from Alcaligenes
                     eutrophus (Ralstonia eutropha) (660 aa), FASTA scores:
                     opt: 2181, E(): 4.6e-124, (52.05% identity in 665 aa
                     overlap); P27550|ACSA_ECOLI|ACS|B4069 from Escherichia
                     coli strain K12 (652 aa), FASTA scores: opt: 1625, E(): 0,
                     (48.3% identity in 646 aa overlap); etc. Contains PS00455
                     Putative AMP-binding domain signature. BELONGS TO THE
                     ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. Protein product
                     from Mb3691 detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb3691 found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P59871"
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR011904"
                     /db_xref="InterPro:IPR020845"
                     /db_xref="InterPro:IPR025110"
                     /db_xref="InterPro:IPR032387"
                     /db_xref="InterPro:IPR042099"
                     /db_xref="UniProtKB/Swiss-Prot:P59871"
BEGIN
        1 MSESTPEVSS SYPPPAHFAE HANARAELYR EAEEDRLAFW AKQANRLSWT TPFTEVLDWS
       61 EAPFAKWFVG GELNVAYNCV DRHVEAGHGD RVAIHWEGEP VGDRRTLTYS DLLAEVSKAA
      121 NALTDLGLVA GDRVAIYLPL IPEAVIAMLA CARLGIMHSV VFGGFTAAAL QARIVDAQAK
      181 LLITADGQFR RGKPSPLKAA ADEALAAIPD CSVEHVLVVR RTGIEMAWSE GRDLWWHHVV
      241 GSASPAHTPE PFDSEHPLFL LYTSGTTGKP KGIMHTSGGY LTQCCYTMRT IFDVKPDSDV
      301 FWCTADIGWV TGHTYGVYGP LCNGVTEVLY EGTPDTPDRH RHFQIIEKYG VTIYYTAPTL
      361 IRMFMKWGRE IPDSHDLSSL RLLGSVGEPI NPEAWRWYRD VIGGGRTPLV DTWWQTETGS
      421 AMISPLPGIA AAKPGSAMTP LPGISAKIVD DHGDPLPPHT EGAQHVTGYL VLDQPWPSML
      481 RGIWGDPARY WHSYWSKFSD KGYYFAGDGA RIDPDGAIWV LGRIDDVMNV SGHRISTAEV
      541 ESALVAHSGV AEAAVVGVTD ETTTQAICAF VVLRANYAPH DRTAEELRTE VARVISPIAR
      601 PRDVHVVPEL PKTRSGKIMR RLLRDVAENR ELGDTSTLLD PTVFDAIRAA K
//