LOCUS       SIU02298.1               934 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 dna
            topoisomerase i topa (omega-protein) (relaxing enzyme)
            (untwisting enzyme) (swivelase) (type i dna topoisomerase)
            (nicking-closing enzyme) (topo i) protein.
ACCESSION   LT708304-3712
PROTEIN_ID  SIU02298.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="topA"
                     /locus_tag="BQ2027_MB3670C"
                     /note="Mb3670c, topA, len: 934 aa. Equivalent to Rv3646c,
                     len: 934 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 934 aa overlap). topA, DNA
                     topoisomerase I (EC 5.99.1.2) (see citation below),
                     equivalent to O69548|TOP1_MYCLE|TOPA|ML0200|MLCB2548.31c
                     DNA TOPOISOMERASE I from Mycobacterium leprae (947 aa)
                     FASTA scores: opt: 5150, E(): 0, (84.6% identity in 936 aa
                     overlap). Also highly similar to many e.g.
                     Q9X909|TOP1_STRCO|TOPA|SCH5.06c from Streptomyces
                     coelicolor (952 aa), FASTA scores: opt: 2754, E():
                     1.3e-153, (61.3% identity in 928 aa overlap);
                     P73810|TOP1_SYNY3|TOPA|SLR2058 from Synechocystis sp.
                     strain PCC 6803 (898 aa), FASTA scores: opt: 1442, E():
                     9.1e-77, (47.15% identity in 927 aa overlap);
                     P47368|TOP1_MYCGE|TOPA|MG122 from Mycoplasma genitalium
                     (709 aa), FASTA scores: opt: 865, E(): 4.8e-43, (30.3%
                     identity in 736 aa overlap);
                     P06612|TOP1_ECOLI|TOPA|SUPX|B1274 from Escherichia coli
                     strain K12 (865 aa), FASTA scores: opt: 397, E(): 0,
                     (39.6% identity in 704 aa overlap); etc. BELONGS TO
                     PROKARYOTIC TYPE I/III TOPOISOMERASE FAMILY. Protein
                     product from Mb3670c detected using shotgun mass
                     spectrometry. Mb3670c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P0A621"
                     /db_xref="InterPro:IPR000380"
                     /db_xref="InterPro:IPR003601"
                     /db_xref="InterPro:IPR003602"
                     /db_xref="InterPro:IPR005733"
                     /db_xref="InterPro:IPR006171"
                     /db_xref="InterPro:IPR013497"
                     /db_xref="InterPro:IPR013824"
                     /db_xref="InterPro:IPR013825"
                     /db_xref="InterPro:IPR013826"
                     /db_xref="InterPro:IPR023405"
                     /db_xref="InterPro:IPR023406"
                     /db_xref="InterPro:IPR025589"
                     /db_xref="InterPro:IPR028612"
                     /db_xref="InterPro:IPR034149"
                     /db_xref="UniProtKB/Swiss-Prot:P0A621"
BEGIN
        1 MADPKTKGRG SGGNGSGRRL VIVESPTKAR KLASYLGSGY IVESSRGHIR DLPRAASDVP
       61 AKYKSQPWAR LGVNVDADFE PLYIISPEKR STVSELRGLL KDVDELYLAT DGDREGEAIA
      121 WHLLETLKPR IPVKRMVFHE ITEPAIRAAA EHPRDLDIDL VDAQETRRIL DRLYGYEVSP
      181 VLWKKVAPKL SAGRVQSVAT RIIVARERDR MAFRSAAYWD ILAKLDASVS DPDAAPPTFS
      241 ARLTAVAGRR VATGRDFDSL GTLRKGDEVI VLDEGSATAL AAGLDGTQLT VASAEEKPYA
      301 RRPYPPFMTS TLQQEASRKL RFSAERTMSI AQRLYENGYI TYMRTDSTTL SESAINAART
      361 QARQLYGDEY VAPAPRQYTR KVKNAQEAHE AIRPAGETFA TPDAVRRELD GPNIDDFRLY
      421 ELIWQRTVAS QMADARGMTL SLRITGMSGH QEVVFSATGR TLTFPGFLKA YVETVDELVG
      481 GEADDAERRL PHLTPGQRLD IVELTPDGHA TNPPARYTEA SLVKALEELG IGRPSTYSSI
      541 IKTIQDRGYV HKKGSALVPS WVAFAVTGLL EQHFGRLVDY DFTAAMEDEL DEIAAGNERR
      601 TNWLNNFYFG GDHGVPDSVA RSGGLKKLVG INLEGIDARE VNSIKLFDDT HGRPIYVRVG
      661 KNGPYLERLV AGDTGEPTPQ RANLSDSITP DELTLQVAEE LFATPQQGRT LGLDPETGHE
      721 IVAREGRFGP YVTEILPEPA ADAAAAAQGV KKRQKAAGPK PRTGSLLRSM DLQTVTLEDA
      781 LRLLSLPRVV GVDPASGEEI TAQNGRYGPY LKRGNDSRSL VTEDQIFTIT LDEALKIYAE
      841 PKRRGRQSAS APPLRELGTD PASGKPMVIK DGRFGPYVTD GETNASLRKG DDVASITDER
      901 AAELLADRRA RGPAKRPARK AARKVPAKKA AKRD
//