LOCUS SIU02278.1 350 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 proteolysis/ nucleotide biosynthesis protein. ACCESSION LT708304-3692 PROTEIN_ID SIU02278.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB3650C" /note="Mb3650c, -, len: 350 aa. Equivalent to Rv3626c, len: 350 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 350 aa overlap). Conserved hypothetical protein, similar to Q9X8I7|SCE9.14c HYPOTHETICAL PROTEIN from Streptomyces coelicolor (375 aa) FASTA scores: opt: 720, E(): 2.2e-38, (41.55% identity in 361 aa overlap); and shows some similarity to Q9HPS0|VNG1497C HYPOTHETICAL PROTEIN (317 aa) FASTA scores: opt: 226, E(): 4.5e-07, (29.7% identity in 347 aa overlap). Contains neutral zinc metallopeptidases, zinc-binding region signature (PS00142). Protein product from Mb3650c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb3650c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="InterPro:IPR018766" /db_xref="InterPro:IPR022454" /db_xref="InterPro:IPR042271" /db_xref="UniProtKB/TrEMBL:A0A1R3Y4S6" BEGIN 1 MTGASELTLG NTVDWEFAAS VGERLARPAP PSTEYTRRQV IDELTVAAEK AEPPVRDVTG 61 LIADGVVPPA RVVDRPAWIR SAAESMRAMT HGSAKPRGFL TGRITGAQTG AVLAFVASGI 121 LGQYDPFGAA GEGCLLLVYP NVIAVERQLR VEPSDFRLWV CLHEVTHRVQ FTANPWLSGY 181 MSQALNLLTF EPVDDIGRVV SRLADFIRSR GHGTDDSEVN PSGILGLVRA VQSEPQRKAL 241 DQLLVLGTLL EGHAEHVMDA VGPMVVPSVA TIRRRFDDRR HHKQPPLQRL VRALLGFDAK 301 LSQYTRGKAF VDHVVDRAGM KLFNTIWSGP ETLPLPAEIE NPQRWIDRVL //