LOCUS       SIU02277.1               323 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            CELL CYCLE PROTEIN MESJ protein.
ACCESSION   LT708304-3691
PROTEIN_ID  SIU02277.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mesJ"
                     /locus_tag="BQ2027_MB3649C"
                     /note="Mb3649c, mesJ, len: 323 aa. Equivalent to Rv3625c,
                     len: 323 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 323 aa overlap). Possible mesJ, cell
                     cycle protein, equivalent to
                     O69538|Y0C5_MYCLE|ML0213|MLCB2548.18c HYPOTHETICAL 34.1
                     KDA PROTEIN from Mycobacterium leprae (323 aa) FASTA
                     scores: opt: 1592, E(): 9e-92, (78.0% identity in 327 aa
                     overlap). Similar to bacterial hypothetical proteins
                     Q9X8I6|SCE9.13c from Streptomyces coelicolor (352 aa)
                     FASTA scores: opt: 705, E(): 1.4e-36, (47.85% identity in
                     305 aa overlap); and Q9HXZ3|PA3638 from Pseudomonas
                     aeruginosa (442 aa), FASTA scores: opt: 382, E(): 2e-16,
                     (40.6% identity in 271 aa overlap). But also similar (or
                     with similarity) to bacterial cell cycle proteins (MESJ)
                     e.g. Q9KPX0|VC2242 MESJ PROTEIN from Vibrio cholerae (440
                     aa), FASTA scores: opt: 363, E(): 3e-15, (34.8% identity
                     in 253 aa overlap); Q9RV23|DR1207 (600 aa) CELL CYCLE
                     PROTEIN MESJ (PUTATIVE/CYTOSINE DEAMINASE-RELATED PROTEIN)
                     from Deinococcus radiodurans (600 aa), FASTA scores: opt:
                     310, E(): 7.6e-12, (36.6% identity in 265 aa overlap)
                     (similar only at the N-terminal end); Q9PFJ8|XF0659 CELL
                     CYCLE PROTEIN from Xylella fastidiosa (437 aa), FASTA
                     scores: opt: 301, E(): 2.1e-11, (35.05% identity in 271 aa
                     overlap); P52097|MESJ_ECOLI|B0188 PUTATIVE CELL CYCLE
                     PROTEIN MESJ from Escherichia coli strain K12(432 aa)
                     FASTA scores: opt: 299, E(): 2.8e-11, (34.65% identity in
                     277 aa overlap); etc. BELONGS TO THE UPF0072 (MESJ/YCF62)
                     FAMILY. Protein product from Mb3649c detected using SWATH
                     mass spectrometry. Mb3649c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P67152"
                     /db_xref="InterPro:IPR011063"
                     /db_xref="InterPro:IPR012094"
                     /db_xref="InterPro:IPR012795"
                     /db_xref="InterPro:IPR014729"
                     /db_xref="InterPro:IPR015262"
                     /db_xref="UniProtKB/Swiss-Prot:P67152"
BEGIN
        1 MDRQSAVAQL RAAAEQFARV HLDACDRWSV GLSGGPDSLA LTAVAARLWP TTALIVDHGL
       61 QPGSATVAET ARIQAISLGC VDARVLCVQV GAAGGREAAA RSARYSALEE HRDGPVLLAH
      121 TLDDQAETVL LGLGRGSGAR SIAGMRPYDP PWCRPLLGVR RSVTHAACRE LGLTAWQDPH
      181 NTDRRFTRTR LRTEVLPLLE DVLGGGVAEA LARTATALRE DTDLIDTIAA QALPGAAVAG
      241 SRGQELSTSA LTALPDAVRR RVIRGWLLAG GATGLTDRQI RGVDRLVTAW RGQGGVAVGS
      301 TLRGQRLVAG RRDGVLVLRR EPV
//