LOCUS       SIU02268.1               760 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 MEMBRANE-
            BOUND PROTEASE FTSH (CELL DIVISION PROTEIN) protein.
ACCESSION   LT708304-3682
PROTEIN_ID  SIU02268.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="ftsH"
                     /locus_tag="BQ2027_MB3640C"
                     /note="Mb3640c, ftsH, len: 760 aa. Equivalent to Rv3610c,
                     len: 760 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 760 aa overlap). ftsH, membrane-bound
                     protease (cell division protein) (EC 3.4.24.-) (see
                     citation below), equivalent to Q9CD58|FTSH_MYCLE|ML0222
                     (alias O69532|FTSH) CELL DIVISION PROTEIN FTSH HOMOLOG
                     from Mycobacterium leprae (787 aa), FASTA scores: opt:
                     4388, E(): 9.6e-205, (87.2% identity in 790 aa overlap).
                     Also highly similar to many FTSH proteins e.g. O52395|FTSH
                     from Mycobacterium smegmatis (769 aa), FASTA scores: opt:
                     3976, E(): 7.6e-185, (82.4% identity in 761 aa overlap);
                     Q9X8I4|SCE9.11c from Streptomyces coelicolor (668 aa),
                     FASTA scores: opt: 2417, E(): 1.4e-109, (57.2% identity in
                     668 aa overlap); P72991|FTH4_SYNY3|SLR1604 from
                     Synechocystis sp. strain PCC 6803 (616 aa), FASTA scores:
                     opt: 1926, E(): 7.2e-86, (49.35% identity in 612 aa
                     overlap); P28691|FTSH_ECOLI|HFLB|MRSC|TOLZ|B3178 from
                     Escherichia coli strain K12 (644 aa), FASTA scores: opt:
                     1859, E(): 1.3e-82, (48.95% identity in 605 aa overlap);
                     etc. Contains PS00017 ATP/GTP-binding site motif A
                     (P-loop), and PS00674 AAA-protein family signature.
                     BELONGS TO THE AAA FAMILY OF ATPASES AND PEPTIDASE FAMILY
                     M41 (ZINC METALLOPROTEASE). COFACTOR: BINDS ONE ZINC ION
                     (POTENTIAL). Protein product from Mb3640c detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb3640c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:P0A4V9"
                     /db_xref="InterPro:IPR000642"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR003959"
                     /db_xref="InterPro:IPR003960"
                     /db_xref="InterPro:IPR005936"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="InterPro:IPR037219"
                     /db_xref="InterPro:IPR041569"
                     /db_xref="UniProtKB/Swiss-Prot:P0A4V9"
BEGIN
        1 MNRKNVTRTI TAIAVVVLLG WSFFYFSDDT RGYKPVDTSV AITQINGDNV KSAQIDDREQ
       61 QLRLILKKGN NETDGSEKVI TKYPTGYAVD LFNALSAKNA KVSTVVNQGS ILGELLVYVL
      121 PLLLLVGLFV MFSRMQGGAR MGFGFGKSRA KQLSKDMPKT TFADVAGVDE AVEELYEIKD
      181 FLQNPSRYQA LGAKIPKGVL LYGPPGTGKT LLARAVAGEA GVPFFTISGS DFVEMFVGVG
      241 ASRVRDLFEQ AKQNSPCIIF VDEIDAVGRQ RGAGLGGGHD EREQTLNQLL VEMDGFGDRA
      301 GVILIAATNR PDILDPALLR PGRFDRQIPV SNPDLAGRRA VLRVHSKGKP MAADADLDGL
      361 AKRTVGMTGA DLANVINEAA LLTARENGTV ITGPALEEAV DRVIGGPRRK GRIISEQEKK
      421 ITAYHEGGHT LAAWAMPDIE PIYKVTILAR GRTGGHAVAV PEEDKGLRTR SEMIAQLVFA
      481 MGGRAAEELV FREPTTGAVS DIEQATKIAR SMVTEFGMSS KLGAVKYGSE HGDPFLGRTM
      541 GTQPDYSHEV AREIDEEVRK LIEAAHTEAW EILTEYRDVL DTLAGELLEK ETLHRPELES
      601 IFADVEKRPR LTMFDDFGGR IPSDKPPIKT PGELAIERGE PWPQPVPEPA FKAAIAQATQ
      661 AAEAARSDAG QTGHGANGSP AGTHRSGDRQ YGSTQPDYGA PAGWHAPGWP PRSSHRPSYS
      721 GEPAPTYPGQ PYPTGQADPG SDESSAEQDD EVSRTKPAHG
//