LOCUS SIU02268.1 760 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 MEMBRANE- BOUND PROTEASE FTSH (CELL DIVISION PROTEIN) protein. ACCESSION LT708304-3682 PROTEIN_ID SIU02268.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="ftsH" /locus_tag="BQ2027_MB3640C" /note="Mb3640c, ftsH, len: 760 aa. Equivalent to Rv3610c, len: 760 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 760 aa overlap). ftsH, membrane-bound protease (cell division protein) (EC 3.4.24.-) (see citation below), equivalent to Q9CD58|FTSH_MYCLE|ML0222 (alias O69532|FTSH) CELL DIVISION PROTEIN FTSH HOMOLOG from Mycobacterium leprae (787 aa), FASTA scores: opt: 4388, E(): 9.6e-205, (87.2% identity in 790 aa overlap). Also highly similar to many FTSH proteins e.g. O52395|FTSH from Mycobacterium smegmatis (769 aa), FASTA scores: opt: 3976, E(): 7.6e-185, (82.4% identity in 761 aa overlap); Q9X8I4|SCE9.11c from Streptomyces coelicolor (668 aa), FASTA scores: opt: 2417, E(): 1.4e-109, (57.2% identity in 668 aa overlap); P72991|FTH4_SYNY3|SLR1604 from Synechocystis sp. strain PCC 6803 (616 aa), FASTA scores: opt: 1926, E(): 7.2e-86, (49.35% identity in 612 aa overlap); P28691|FTSH_ECOLI|HFLB|MRSC|TOLZ|B3178 from Escherichia coli strain K12 (644 aa), FASTA scores: opt: 1859, E(): 1.3e-82, (48.95% identity in 605 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00674 AAA-protein family signature. BELONGS TO THE AAA FAMILY OF ATPASES AND PEPTIDASE FAMILY M41 (ZINC METALLOPROTEASE). COFACTOR: BINDS ONE ZINC ION (POTENTIAL). Protein product from Mb3640c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb3640c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:P0A4V9" /db_xref="InterPro:IPR000642" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR005936" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR037219" /db_xref="InterPro:IPR041569" /db_xref="UniProtKB/Swiss-Prot:P0A4V9" BEGIN 1 MNRKNVTRTI TAIAVVVLLG WSFFYFSDDT RGYKPVDTSV AITQINGDNV KSAQIDDREQ 61 QLRLILKKGN NETDGSEKVI TKYPTGYAVD LFNALSAKNA KVSTVVNQGS ILGELLVYVL 121 PLLLLVGLFV MFSRMQGGAR MGFGFGKSRA KQLSKDMPKT TFADVAGVDE AVEELYEIKD 181 FLQNPSRYQA LGAKIPKGVL LYGPPGTGKT LLARAVAGEA GVPFFTISGS DFVEMFVGVG 241 ASRVRDLFEQ AKQNSPCIIF VDEIDAVGRQ RGAGLGGGHD EREQTLNQLL VEMDGFGDRA 301 GVILIAATNR PDILDPALLR PGRFDRQIPV SNPDLAGRRA VLRVHSKGKP MAADADLDGL 361 AKRTVGMTGA DLANVINEAA LLTARENGTV ITGPALEEAV DRVIGGPRRK GRIISEQEKK 421 ITAYHEGGHT LAAWAMPDIE PIYKVTILAR GRTGGHAVAV PEEDKGLRTR SEMIAQLVFA 481 MGGRAAEELV FREPTTGAVS DIEQATKIAR SMVTEFGMSS KLGAVKYGSE HGDPFLGRTM 541 GTQPDYSHEV AREIDEEVRK LIEAAHTEAW EILTEYRDVL DTLAGELLEK ETLHRPELES 601 IFADVEKRPR LTMFDDFGGR IPSDKPPIKT PGELAIERGE PWPQPVPEPA FKAAIAQATQ 661 AAEAARSDAG QTGHGANGSP AGTHRSGDRQ YGSTQPDYGA PAGWHAPGWP PRSSHRPSYS 721 GEPAPTYPGQ PYPTGQADPG SDESSAEQDD EVSRTKPAHG //