LOCUS       SIU02253.1               492 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 pe-
            pgrs family protein pe_pgrs59 protein.
ACCESSION   LT708304-3667
PROTEIN_ID  SIU02253.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="PE_PGRS59"
                     /locus_tag="BQ2027_MB3626C"
                     /note="Mb3626c, PE_PGRS59, len: 492 aa. Equivalent to 5'
                     end of Rv3595c, len: 439 aa, from Mycobacterium
                     tuberculosis strain H37Rv, (100.0% identity in 257 aa
                     overlap). Member of the Mycobacterium tuberculosis PE
                     family, PGRS subfamily of gly-rich proteins, similar to
                     many e.g. O53439|Rv1091|MTV017.44 (853 aa), FASTA scores:
                     opt: 1644, E(): 1.2e-57, (58.75% identity in 492 aa
                     overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium
                     bovis, a single base deletion (a-*) and a 27 bp insertion
                     (*-gcgcgccggggccaccgtttccgccgg), lead to a longer product
                     with a different COOH part compared to its homolog in
                     Mycobacterium tuberculosis (492 aa versus 439 aa). Mb3626c
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="InterPro:IPR000084"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y4K4"
BEGIN
        1 MSFVIAVPEF LSAAATDLAN LGSTISAANA AASIPTTGVL AAGADDVSAA IAALFGAHAQ
       61 AYQTISAQAA TFHAQFVQTL SAGAGAYANA EAANVQQSLL NAINAPTQAL LGRPLIGDGA
      121 DGTAPGQNGG AGGLLYGNGG NGAAGVNAGI AGGSGGAAGL IGNGGSGGAG GAGAAGGSGG
      181 QGGLLYGNGG AGGNGGAATI PGGNGGAGGA GGNAWLFGNG GAGGLGAAGA AGAAGVNPLT
      241 VPAGQGSMGN NGEPGGPASQ APSSGKPVAP VALAVLACPL AGPAGPAETV APARPAAPGG
      301 PAGPAALAVG VGSWSATAAQ VASGAQGAKA ASAPGAAPAV RAEWAAPGNQ ALGVTLVTGV
      361 TAGSAVTAAP AETAARAARA ARAACSASPV APGWAVPPVA GVMAGAVVSP VWPAPRALGL
      421 RAVAATATSA SSALKVHPAS PASRASPVDI VAAGPSAPRR LLEQLPSVTG PVEALARVEF
      481 CGQGVDLIAE LG
//