LOCUS SIU02253.1 492 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 pe- pgrs family protein pe_pgrs59 protein. ACCESSION LT708304-3667 PROTEIN_ID SIU02253.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="PE_PGRS59" /locus_tag="BQ2027_MB3626C" /note="Mb3626c, PE_PGRS59, len: 492 aa. Equivalent to 5' end of Rv3595c, len: 439 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 257 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many e.g. O53439|Rv1091|MTV017.44 (853 aa), FASTA scores: opt: 1644, E(): 1.2e-57, (58.75% identity in 492 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base deletion (a-*) and a 27 bp insertion (*-gcgcgccggggccaccgtttccgccgg), lead to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis (492 aa versus 439 aa). Mb3626c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="InterPro:IPR000084" /db_xref="UniProtKB/TrEMBL:A0A1R3Y4K4" BEGIN 1 MSFVIAVPEF LSAAATDLAN LGSTISAANA AASIPTTGVL AAGADDVSAA IAALFGAHAQ 61 AYQTISAQAA TFHAQFVQTL SAGAGAYANA EAANVQQSLL NAINAPTQAL LGRPLIGDGA 121 DGTAPGQNGG AGGLLYGNGG NGAAGVNAGI AGGSGGAAGL IGNGGSGGAG GAGAAGGSGG 181 QGGLLYGNGG AGGNGGAATI PGGNGGAGGA GGNAWLFGNG GAGGLGAAGA AGAAGVNPLT 241 VPAGQGSMGN NGEPGGPASQ APSSGKPVAP VALAVLACPL AGPAGPAETV APARPAAPGG 301 PAGPAALAVG VGSWSATAAQ VASGAQGAKA ASAPGAAPAV RAEWAAPGNQ ALGVTLVTGV 361 TAGSAVTAAP AETAARAARA ARAACSASPV APGWAVPPVA GVMAGAVVSP VWPAPRALGL 421 RAVAATATSA SSALKVHPAS PASRASPVDI VAAGPSAPRR LLEQLPSVTG PVEALARVEF 481 CGQGVDLIAE LG //