LOCUS SIU02247.1 304 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 probable adenine glycosylase muty protein. ACCESSION LT708304-3661 PROTEIN_ID SIU02247.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="mutY" /locus_tag="BQ2027_MB3620" /note="Mb3620, mutY, len: 304 aa. Equivalent to Rv3589, len: 304 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 304 aa overlap). Probable mutY, adenine glycosylase (EC 3.2.2.-), equivalent to Q9CBJ0|MUTY|ML1920 PROBABLE DNA GLYCOSYLASE from Mycobacterium leprae (297 aa), FASTA scores: opt: 1592, E(): 2.6e-94, (74.9% identity in 303 aa overlap). Also similar to many DNA glycosylases (generally adenine glycosylases) e.g. Q9S6T7|SCE94.06 from Streptomyces coelicolor (308 aa), FASTA scores: opt: 965, E(): 2.6e-54, (50.5% identity in 297 aa overlap); Q9S6G1|MUTY from Streptomyces antibioticus (307 aa), FASTA scores: opt: 901, E(): 3.1e-50, (48.5% identity in 303 aa overlap); Q9HPQ6|MUTY|VNG1520G from Halobacterium sp. strain NRC-1 (312 aa), FASTA scores: opt: 566, E(): 7.2e-29, (39.85% identity in 296 aa overlap); BAB53965|MLL7523 from Rhizobium loti (Mesorhizobium loti) (396 aa), FASTA scores: opt: 511, E(): 2.8e-25, (39.65% identity in 237 aa overlap); Q05869|MUTY_SALTY|MUTB from Salmonella typhimurium (350 aa), FASTA scores: opt: 421, E(): 3.8e-20, (35.2% identity in 227 aa overlap); etc. COULD BELONG TO THE NTH/MUTY FAMILY. Mb3620 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y4K5" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="UniProtKB/TrEMBL:A0A1R3Y4K5" BEGIN 1 MPHILPEPSV TGPRHISDTN LLAWYQRSHR DLPWREPGVS PWQILVSEFM LQQTPAARVL 61 AIWPDWVRRW PTPSATATAS TADVLRAWGK LGYPRRAKRL HECATVIARD HNDVVPDDIE 121 ILVTLPGVGS YTARAVACFA YRQRVPVVDT NVRRVVARAV HGRADAGAPS VPRDHADVLA 181 LLPHRETAPE FSVALMELGA TVCTARTPRC GLCPLDWCAW RHAGYPPSDG PPRRGQAYTG 241 TDRQVRGRLL DVLRAAEFPV TRAELDVAWL TDTAQRDRAL ESLLADALVT RTVDGRFALP 301 GEGF //