LOCUS       SIU02247.1               304 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            adenine glycosylase muty protein.
ACCESSION   LT708304-3661
PROTEIN_ID  SIU02247.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mutY"
                     /locus_tag="BQ2027_MB3620"
                     /note="Mb3620, mutY, len: 304 aa. Equivalent to Rv3589,
                     len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 304 aa overlap). Probable mutY,
                     adenine glycosylase (EC 3.2.2.-), equivalent to
                     Q9CBJ0|MUTY|ML1920 PROBABLE DNA GLYCOSYLASE from
                     Mycobacterium leprae (297 aa), FASTA scores: opt: 1592,
                     E(): 2.6e-94, (74.9% identity in 303 aa overlap). Also
                     similar to many DNA glycosylases (generally adenine
                     glycosylases) e.g. Q9S6T7|SCE94.06 from Streptomyces
                     coelicolor (308 aa), FASTA scores: opt: 965, E(): 2.6e-54,
                     (50.5% identity in 297 aa overlap); Q9S6G1|MUTY from
                     Streptomyces antibioticus (307 aa), FASTA scores: opt:
                     901, E(): 3.1e-50, (48.5% identity in 303 aa overlap);
                     Q9HPQ6|MUTY|VNG1520G from Halobacterium sp. strain NRC-1
                     (312 aa), FASTA scores: opt: 566, E(): 7.2e-29, (39.85%
                     identity in 296 aa overlap); BAB53965|MLL7523 from
                     Rhizobium loti (Mesorhizobium loti) (396 aa), FASTA
                     scores: opt: 511, E(): 2.8e-25, (39.65% identity in 237 aa
                     overlap); Q05869|MUTY_SALTY|MUTB from Salmonella
                     typhimurium (350 aa), FASTA scores: opt: 421, E():
                     3.8e-20, (35.2% identity in 227 aa overlap); etc. COULD
                     BELONG TO THE NTH/MUTY FAMILY. Mb3620 found to be
                     expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y4K5"
                     /db_xref="InterPro:IPR000445"
                     /db_xref="InterPro:IPR003265"
                     /db_xref="InterPro:IPR003651"
                     /db_xref="InterPro:IPR011257"
                     /db_xref="InterPro:IPR023170"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y4K5"
BEGIN
        1 MPHILPEPSV TGPRHISDTN LLAWYQRSHR DLPWREPGVS PWQILVSEFM LQQTPAARVL
       61 AIWPDWVRRW PTPSATATAS TADVLRAWGK LGYPRRAKRL HECATVIARD HNDVVPDDIE
      121 ILVTLPGVGS YTARAVACFA YRQRVPVVDT NVRRVVARAV HGRADAGAPS VPRDHADVLA
      181 LLPHRETAPE FSVALMELGA TVCTARTPRC GLCPLDWCAW RHAGYPPSDG PPRRGQAYTG
      241 TDRQVRGRLL DVLRAAEFPV TRAELDVAWL TDTAQRDRAL ESLLADALVT RTVDGRFALP
      301 GEGF
//