LOCUS       SIU02237.1               322 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 possible
            trna/rrna methyltransferase protein.
ACCESSION   LT708304-3651
PROTEIN_ID  SIU02237.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3610C"
                     /note="Mb3610c, -, len: 322 aa. Equivalent to Rv3579c,
                     len: 322 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99% identity in 322 aa overlap). Putative tRNA/rRNA
                     methyltransferase (EC 2.1.1.-), equivalent, but longer, to
                     Q9CCW4|ML0324 PUTATIVE METHYLTRANSFERASE from
                     Mycobacterium leprae (278 aa),
                     REMARK-M.bovis-M.tuberculosis: In the original M.bovis
                     genome, a single base insertion (*-g) led to a longer
                     product with a different COOH part compared to its homolog
                     in Mycobacterium strain H37Rv (402 aa versus 322 aa). This
                     was corrected in the new M.bovis genome update to a 322aa
                     product Protein product from Mb3610c detected using SWATH
                     mass spectrometry. Mb3610c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:Q7TW55"
                     /db_xref="InterPro:IPR001537"
                     /db_xref="InterPro:IPR004441"
                     /db_xref="InterPro:IPR013123"
                     /db_xref="InterPro:IPR029026"
                     /db_xref="InterPro:IPR029028"
                     /db_xref="InterPro:IPR029064"
                     /db_xref="UniProtKB/Swiss-Prot:Q7TW55"
BEGIN
        1 MPGNSRRRGA VRKSGTKKGA GVGSGGQRRR GLEGRGPTPP AHLRPHHPAA KRARAQPRRP
       61 VKRADETETV LGRNPVLECL RAGVPATALY VALGTEADER LTECVARAAD SGIAIVELLR
      121 ADLDRMTANH LHQGIALQVP PYNYAHPDDL LAAALDQPPA LLVALDNLSD PRNLGAIMRS
      181 VAAFGGHGVL IPQRRSASVT AVAWRTSAGA AARIPVARAT NLTRTLKGWA DRGVRVIGLD
      241 AGGGTALDDV DGTDSLVVVV GSEGKGLSRL VRQNCDEVVS IPMAAQAESL NASVAAGVVL
      301 AAIARQRRRP REPREQTQNR MI
//