LOCUS       SIU02220.1               319 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            ACYL-COA DEHYDROGENASE FADE32 protein.
ACCESSION   LT708304-3634
PROTEIN_ID  SIU02220.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="fadE32"
                     /locus_tag="BQ2027_MB3593"
                     /note="Mb3593, fadE32, len: 319 aa. Equivalent to Rv3563,
                     len: 319 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.4% identity in 319 aa overlap). Probable fadE32,
                     acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g.
                     Q9I4V4|PA1020 from Pseudomonas aeruginosa (370 aa), FASTA
                     scores: opt: 347, E(): 7.6e-14, (35.15% identity in 333 aa
                     overlap); Q9RJX3|SCF37.28c from Streptomyces coelicolor
                     (362 aa), FASTA scores: opt: 300, E(): 5.3e-11, (32.4%
                     identity in 349 aa overlap); Q9A5G8|CC2479 from
                     Caulobacter crescentus (344 aa), FASTA scores: opt: 285,
                     E(): 4.1e-10, (30.4% identity in 329 aa overlap);
                     P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa),
                     FASTA scores: opt: 230, E(): 1.1e-07, (25.5% identity in
                     357 aa overlap); etc. Also similar to other from
                     Mycobacterium tuberculosis eg
                     P96846|FADE33|Rv3564|MTCY06G11.11 (318 aa), FASTA scores:
                     opt: 478, E(): 7.6e-22, (32.9% identity in 292 aa
                     overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES
                     FAMILY. Protein product from Mb3593 detected using SWATH
                     mass spectrometry."
                     /db_xref="GOA:A0A1R3Y4I6"
                     /db_xref="InterPro:IPR009075"
                     /db_xref="InterPro:IPR009100"
                     /db_xref="InterPro:IPR013786"
                     /db_xref="InterPro:IPR036250"
                     /db_xref="InterPro:IPR037069"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y4I6"
BEGIN
        1 MTMEFALNEQ QRDFAASIDA ALGAADLPGV VRAWAAGDVA PGRKVWQQLA NLGVTALGVA
       61 EKFDGLGASP VDLVVALERL GRWCVPGPVT ESIAVAPILL AHDDRAERSH GLASGELIAT
      121 VAMPPRVPRA VDADTAGLVL LAGDGSVTEG TPGDCHRSVD PSRRLYEVAA SGQAWRAPKD
      181 VVARAYEFGA LATAAQLVGA GQALLEAAVN YAKQRTQFGR AIGSYQAIKH KLADVHIAIE
      241 LACPLVYGAA VSLEPRDVSA AKAAASEAAL LAARSALQTH GAIGFTCEHD LSLWLLRVQA
      301 LHSAWGTPQE HRRRVLEAL
//