LOCUS SIU02220.1 319 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE ACYL-COA DEHYDROGENASE FADE32 protein. ACCESSION LT708304-3634 PROTEIN_ID SIU02220.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="fadE32" /locus_tag="BQ2027_MB3593" /note="Mb3593, fadE32, len: 319 aa. Equivalent to Rv3563, len: 319 aa, from Mycobacterium tuberculosis strain H37Rv, (99.4% identity in 319 aa overlap). Probable fadE32, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. Q9I4V4|PA1020 from Pseudomonas aeruginosa (370 aa), FASTA scores: opt: 347, E(): 7.6e-14, (35.15% identity in 333 aa overlap); Q9RJX3|SCF37.28c from Streptomyces coelicolor (362 aa), FASTA scores: opt: 300, E(): 5.3e-11, (32.4% identity in 349 aa overlap); Q9A5G8|CC2479 from Caulobacter crescentus (344 aa), FASTA scores: opt: 285, E(): 4.1e-10, (30.4% identity in 329 aa overlap); P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa), FASTA scores: opt: 230, E(): 1.1e-07, (25.5% identity in 357 aa overlap); etc. Also similar to other from Mycobacterium tuberculosis eg P96846|FADE33|Rv3564|MTCY06G11.11 (318 aa), FASTA scores: opt: 478, E(): 7.6e-22, (32.9% identity in 292 aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY. Protein product from Mb3593 detected using SWATH mass spectrometry." /db_xref="GOA:A0A1R3Y4I6" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="UniProtKB/TrEMBL:A0A1R3Y4I6" BEGIN 1 MTMEFALNEQ QRDFAASIDA ALGAADLPGV VRAWAAGDVA PGRKVWQQLA NLGVTALGVA 61 EKFDGLGASP VDLVVALERL GRWCVPGPVT ESIAVAPILL AHDDRAERSH GLASGELIAT 121 VAMPPRVPRA VDADTAGLVL LAGDGSVTEG TPGDCHRSVD PSRRLYEVAA SGQAWRAPKD 181 VVARAYEFGA LATAAQLVGA GQALLEAAVN YAKQRTQFGR AIGSYQAIKH KLADVHIAIE 241 LACPLVYGAA VSLEPRDVSA AKAAASEAAL LAARSALQTH GAIGFTCEHD LSLWLLRVQA 301 LHSAWGTPQE HRRRVLEAL //