LOCUS       SIU02214.1               200 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 transcriptional
            regulatory protein (probably tetr-family) protein.
ACCESSION   LT708304-3628
PROTEIN_ID  SIU02214.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3587C"
                     /note="Mb3587c, -, len: 200 aa. Equivalent to Rv3557c,
                     len: 200 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 200 aa overlap). Probable
                     transcriptional regulator, tetR family, similar to other
                     e.g. Q9RRV9|DR2376 from Deinococcus radiodurans (197 aa)
                     FASTA scores: opt: 326, E(): 2.3e-14, (31.2% identity in
                     189 aa overlap); Q9HZW2|PA2885 from Pseudomonas aeruginosa
                     (198 aa), FASTA scores: opt: 308, E(): 3.5e-13, (31.55%
                     identity in 187 aa overlap); Q9RFR4 from Pseudomonas
                     fluorescens (207 aa), FASTA scores: opt: 291, E():
                     4.7e-12, (29.75% identity in 195 aa overlap);
                     Q9K8P5|BH2958 from Bacillus halodurans (215 aa), FASTA
                     scores: opt: 271, E(): 9.9e-11, (23.95% identity in 192 aa
                     overlap); etc. Also similar to proteins from Mycobacterium
                     tuberculosis e.g. O53641|Rv0158|MTV032.01 (214 aa), FASTA
                     scores: opt: 232, E(): 3.5e-08, (25.5% identity in 192 aa
                     overlap); and O06169|Rv2506|MTCY07A7.12 (215 aa), FASTA
                     scores: opt: 215, E(): 4.5e-07, (35.15% identity in 148 aa
                     overlap); etc. SEEMS TO BELONG TO THE TETR/ACRR FAMILY OF
                     TRANSCRIPTIONAL REGULATORS. Protein product from Mb3587c
                     detected using SWATH mass spectrometry. Mb3587c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y4J0"
                     /db_xref="InterPro:IPR001647"
                     /db_xref="InterPro:IPR009057"
                     /db_xref="InterPro:IPR036271"
                     /db_xref="InterPro:IPR041490"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y4J0"
BEGIN
        1 MDRVAGQVNS RRGELLELAA AMFAERGLRA TTVRDIADGA GILSGSLYHH FASKEEMVDE
       61 LLRGFLDWLF ARYRDIVDST ANPLERLQGL FMASFEAIEH HHAQVVIYQD EAQRLASQPR
      121 FSYIEDRNKQ QRKMWVDVLN QGIEEGYFRP DLDVDLVYRF IRDTTWVSVR WYRPGGPLTA
      181 QQVGQQYLAI VLGGITKEGV
//