LOCUS SIU02213.1 386 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE ACETYL-COA ACETYLTRANSFERASE FADA6 (ACETOACETYL-COA THIOLASE) protein. ACCESSION LT708304-3627 PROTEIN_ID SIU02213.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="fadA6" /locus_tag="BQ2027_MB3586C" /note="Mb3586c, fadA6, len: 386 aa. Equivalent to Rv3556c, len: 386 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 386 aa overlap). Probable fadA6, acetyl-CoA acetyltransferase (EC 2.3.1.9), similar to many e.g. Q9K409|2SCG61.06c from Streptomyces coelicolor (389 aa), FASTA scores: opt: 1091, E(): 2.9e-58, (48.1% identity in 399 aa overlap); Q9AAT4|CC0510 from Caulobacter crescentus (391 aa), FASTA scores: opt: 902, E(): 6.6e-47, (40.25% identity in 395 aa overlap); P45359|THL_CLOAB from Clostridium acetobutylicum (392 aa), FASTA scores: opt: 872, E(): 4.2e-45, (37.9% identity in 396 aa overlap); Q9I2A8|ATOB|PA2001 from Pseudomonas aeruginosa (393 aa), FASTA scores: opt: 872, E(): 4.2e-45, (41.3% identity in 397 aa overlap); etc. Contains PS00737 Thiolases signature 2. BELONGS TO THE THIOLASE FAMILY. Protein product from Mb3586c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb3586c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y4G6" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="UniProtKB/TrEMBL:A0A1R3Y4G6" BEGIN 1 MTEAYVIDAV RTAVGKRGGA LAGIHPVDLG ALAWRGLLDR TDIDPAAVDD VIAGCVDAIG 61 GQAGNIARLS WLAAGYPEEV PGVTVDRQCG SSQQAISFGA QAIMSGTADV IVAGGVQNMS 121 QIPISSAMTV GEQFGFTSPT NESKQWLHRY GDQEISQFRG SELIAEKWNL SREEMERYSL 181 TSHERAFAAI RAGHFENEII TVETESGPFR VDEGPRESSL EKMAGLQPLV EGGRLTAAMA 241 SQISDGASAV LLASERAVKD HGLRPRARIH HISARAADPV FMLTGPIPAT RYALDKTGLA 301 IDDIDTVEIN EAFAPVVMAW LKEIKADPAK VNPNGGAIAL GHPLGATGAK LFTTMLGELE 361 RIGGRYGLQT MCEGGGTANV TIIERL //