LOCUS       SIU02213.1               386 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            ACETYL-COA ACETYLTRANSFERASE FADA6 (ACETOACETYL-COA THIOLASE)
            protein.
ACCESSION   LT708304-3627
PROTEIN_ID  SIU02213.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="fadA6"
                     /locus_tag="BQ2027_MB3586C"
                     /note="Mb3586c, fadA6, len: 386 aa. Equivalent to Rv3556c,
                     len: 386 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 386 aa overlap). Probable fadA6,
                     acetyl-CoA acetyltransferase (EC 2.3.1.9), similar to many
                     e.g. Q9K409|2SCG61.06c from Streptomyces coelicolor (389
                     aa), FASTA scores: opt: 1091, E(): 2.9e-58, (48.1%
                     identity in 399 aa overlap); Q9AAT4|CC0510 from
                     Caulobacter crescentus (391 aa), FASTA scores: opt: 902,
                     E(): 6.6e-47, (40.25% identity in 395 aa overlap);
                     P45359|THL_CLOAB from Clostridium acetobutylicum (392 aa),
                     FASTA scores: opt: 872, E(): 4.2e-45, (37.9% identity in
                     396 aa overlap); Q9I2A8|ATOB|PA2001 from Pseudomonas
                     aeruginosa (393 aa), FASTA scores: opt: 872, E(): 4.2e-45,
                     (41.3% identity in 397 aa overlap); etc. Contains PS00737
                     Thiolases signature 2. BELONGS TO THE THIOLASE FAMILY.
                     Protein product from Mb3586c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb3586c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y4G6"
                     /db_xref="InterPro:IPR002155"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="InterPro:IPR020613"
                     /db_xref="InterPro:IPR020616"
                     /db_xref="InterPro:IPR020617"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y4G6"
BEGIN
        1 MTEAYVIDAV RTAVGKRGGA LAGIHPVDLG ALAWRGLLDR TDIDPAAVDD VIAGCVDAIG
       61 GQAGNIARLS WLAAGYPEEV PGVTVDRQCG SSQQAISFGA QAIMSGTADV IVAGGVQNMS
      121 QIPISSAMTV GEQFGFTSPT NESKQWLHRY GDQEISQFRG SELIAEKWNL SREEMERYSL
      181 TSHERAFAAI RAGHFENEII TVETESGPFR VDEGPRESSL EKMAGLQPLV EGGRLTAAMA
      241 SQISDGASAV LLASERAVKD HGLRPRARIH HISARAADPV FMLTGPIPAT RYALDKTGLA
      301 IDDIDTVEIN EAFAPVVMAW LKEIKADPAK VNPNGGAIAL GHPLGATGAK LFTTMLGELE
      361 RIGGRYGLQT MCEGGGTANV TIIERL
//