LOCUS       SIU02203.1               391 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            ACETYL-COA ACETYLTRANSFERASE FADA5 (ACETOACETYL-COA THIOLASE)
            protein.
ACCESSION   LT708304-3617
PROTEIN_ID  SIU02203.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="fadA5"
                     /locus_tag="BQ2027_MB3576"
                     /note="Mb3576, fadA5, len: 391 aa. Equivalent to Rv3546,
                     len: 391 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 391 aa overlap). Probable fadA5,
                     acetyl-CoA acetyltransferase (EC 2.3.1.9), similar to many
                     e.g. Q9AA29|CC0779 from Caulobacter crescentus (390 aa),
                     FASTA scores: opt: 999, E(): 7.1e-54, (43.5% identity in
                     400 aa overlap); Q9K783|BH3487 from Bacillus halodurans
                     (393 aa), FASTA scores: opt: 843, E(): 2.6e-44, (37.45%
                     identity in 398 aa overlap); Q9RRK9|DR2480 from
                     Deinococcus radiodurans (399 aa), FASTA scores: opt: 826,
                     E(): 2.8e-43, (38.15% identity in 396 aa overlap);
                     P45369|THIL_CHRVI|PHBA from Chromatium vinosum (394 aa)
                     FASTA scores: opt: 790, E(): 4.5e-41, (39.4% identity in
                     401 aa overlap); etc. Contains PS00737 Thiolases signature
                     2. BELONGS TO THE THIOLASE FAMILY. Protein product from
                     Mb3576 detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb3576 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y4F3"
                     /db_xref="InterPro:IPR002155"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="InterPro:IPR020613"
                     /db_xref="InterPro:IPR020616"
                     /db_xref="InterPro:IPR020617"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y4F3"
BEGIN
        1 MGYPVIVEAT RSPIGKRNGW LSGLHATELL GAVQKAVVDK AGIQSGLHAG DVEQVIGGCV
       61 TQFGEQSNNI SRVAWLTAGL PEHVGATTVD CQCGSGQQAN HLIAGLIAAG AIDVGIACGI
      121 EAMSRVGLGA NAGPDRSLIR AQSWDIDLPN QFEAAERIAK RRGITREDVD VFGLESQRRA
      181 QRAWAEGRFD REISPIQAPV LDEQNQPTGE RRLVFRDQGL RETTMAGLGE LKPVLEGGIH
      241 TAGTSSQISD GAAAVLWMDE AVARAHGLTP RARIVAQALV GAEPYYHLDG PVQSTAKVLE
      301 KAGMKIGDID IVEINEAFAS VVLSWARVHE PDMDRVNVNG GAIALGHPVG CTGSRLITTA
      361 LHELERTDQS LALITMCAGG ALSTGTIIER I
//