LOCUS SIU02203.1 391 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE ACETYL-COA ACETYLTRANSFERASE FADA5 (ACETOACETYL-COA THIOLASE) protein. ACCESSION LT708304-3617 PROTEIN_ID SIU02203.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="fadA5" /locus_tag="BQ2027_MB3576" /note="Mb3576, fadA5, len: 391 aa. Equivalent to Rv3546, len: 391 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 391 aa overlap). Probable fadA5, acetyl-CoA acetyltransferase (EC 2.3.1.9), similar to many e.g. Q9AA29|CC0779 from Caulobacter crescentus (390 aa), FASTA scores: opt: 999, E(): 7.1e-54, (43.5% identity in 400 aa overlap); Q9K783|BH3487 from Bacillus halodurans (393 aa), FASTA scores: opt: 843, E(): 2.6e-44, (37.45% identity in 398 aa overlap); Q9RRK9|DR2480 from Deinococcus radiodurans (399 aa), FASTA scores: opt: 826, E(): 2.8e-43, (38.15% identity in 396 aa overlap); P45369|THIL_CHRVI|PHBA from Chromatium vinosum (394 aa) FASTA scores: opt: 790, E(): 4.5e-41, (39.4% identity in 401 aa overlap); etc. Contains PS00737 Thiolases signature 2. BELONGS TO THE THIOLASE FAMILY. Protein product from Mb3576 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb3576 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y4F3" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="UniProtKB/TrEMBL:A0A1R3Y4F3" BEGIN 1 MGYPVIVEAT RSPIGKRNGW LSGLHATELL GAVQKAVVDK AGIQSGLHAG DVEQVIGGCV 61 TQFGEQSNNI SRVAWLTAGL PEHVGATTVD CQCGSGQQAN HLIAGLIAAG AIDVGIACGI 121 EAMSRVGLGA NAGPDRSLIR AQSWDIDLPN QFEAAERIAK RRGITREDVD VFGLESQRRA 181 QRAWAEGRFD REISPIQAPV LDEQNQPTGE RRLVFRDQGL RETTMAGLGE LKPVLEGGIH 241 TAGTSSQISD GAAAVLWMDE AVARAHGLTP RARIVAQALV GAEPYYHLDG PVQSTAKVLE 301 KAGMKIGDID IVEINEAFAS VVLSWARVHE PDMDRVNVNG GAIALGHPVG CTGSRLITTA 361 LHELERTDQS LALITMCAGG ALSTGTIIER I //