LOCUS       SIU02202.1               433 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CYTOCHROME P450 125 CYP125 protein.
ACCESSION   LT708304-3616
PROTEIN_ID  SIU02202.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="cyp125"
                     /locus_tag="BQ2027_MB3575C"
                     /note="Mb3575c, cyp125, len: 433 aa. Equivalent to
                     Rv3545c, len: 433 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (100.0% identity in 433 aa overlap).
                     Probable cyp125, cytochrome P-450 (EC 1.14.-.-), similar
                     to others e.g. Q59723|LINC|CYP111 from Pseudomonas
                     incognita (406 aa), FASTA scores: opt: 831, E(): 8e-45,
                     (34.75% identity in 406 aa overlap);
                     Q9X8Q3|CYP107P1|SCH10.14c from Streptomyces coelicolor
                     (411 aa), FASTA scores: opt: 694, E(): 3.3e-36, (32.35%
                     identity in 417 aa overlap); Q9L465|CYP162A1|NIKQ from
                     Streptomyces tendae (396 aa) FASTA scores: opt: 664, E():
                     2.5e-34, (34.15% identity in 413 aa overlap);
                     O08469|CPXY_BACSU|CYPA|CYP107J1 from Bacillus subtilis
                     (410 aa), FASTA scores: opt: 579, E(): 5.6e-29, (30.05%
                     identity in 366 aa overlap); etc. Also similar to other
                     from Mycobacterium tuberculosis e.g.
                     Q50696|CYP124|Rv2266|MT2328|MTCY339.44c (428 aa) FASTA
                     scores: opt: 1040, E(): 6.1e-58, (40.75% identity in 432
                     aa overlap). BELONGS TO THE CYTOCHROME P450 FAMILY.
                     Protein product from Mb3575c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb3575c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:P63710"
                     /db_xref="InterPro:IPR001128"
                     /db_xref="InterPro:IPR002397"
                     /db_xref="InterPro:IPR036396"
                     /db_xref="UniProtKB/Swiss-Prot:P63710"
BEGIN
        1 MSWNHQSVEI AVRRTTVPSP NLPPGFDFTD PAIYAERLPV AEFAELRSAA PIWWNGQDPG
       61 KGGGFHDGGF WAITKLNDVK EISRHSDVFS SYENGVIPRF KNDIAREDIE VQRFVMLNMD
      121 APHHTRLRKI ISRGFTPRAV GRLHDELQER AQKIAAEAAA AGSGDFVEQV SCELPLQAIA
      181 GLLGVPQEDR GKLFHWSNEM TGNEDPEYAH IDPKASSAEL IGYAMKMAEE KAKNPADDIV
      241 TQLIQADIDG EKLSDDEFGF FVVMLAVAGN ETTRNSITQG MMAFAEHPDQ WELYKKVRPE
      301 TAADEIVRWA TPVTAFQRTA LRDYELSGVQ IKKGQRVVMF YRSANFDEEV FQDPFTFNIL
      361 RNPNPHVGFG GTGAHYCIGA NLARMTINLI FNAVADHMPD LKPISAPERL RSGWLNGIKH
      421 WQVDYTGRCP VAH
//