LOCUS       SIU02195.1               286 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            dehydrogenase. possible 2-enoyl acyl-coa hydratase. protein.
ACCESSION   LT708304-3609
PROTEIN_ID  SIU02195.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3568"
                     /note="Mb3568, -, len: 286 aa. Equivalent to Rv3538, len:
                     286 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 286 aa overlap). Probable
                     dehydrogenase (EC 1.-.-.-), similar to Q9L009|SCC30.12c
                     PUTATIVE DEHYDROGENASE from Streptomyces coelicolor (333
                     aa), FASTA scores: opt: 842, E(): 3.6e-44, (48.4% identity
                     in 285 aa overlap); and similar to C-terminal part of
                     other (principally ESTRADIOL 17
                     BETA-DEHYDROGENASES/17-BETA-HYDROXYSTEROID DEHYDROGENASES)
                     e.g. P70540 PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE II
                     (SDR FAMILY) from Rattus norvegicus (Rat) (735 aa) FASTA
                     scores: opt: 622, E(): 1.9e-30, (37.45% identity in 283 aa
                     overlap); or P70523|MPF-2 MULTIFUNCTIONAL PROTEIN 2 (SDR
                     FAMILY) (beta-oxidation protein displaying 2-enoyl-CoA
                     hydratase and D-3-hydroxyacyl-CoA dehydrogenase activity)
                     from Rattus norvegicus (Rat) (734 aa), FASTA scores: opt:
                     616, E(): 4.3e-30, (37.1% identity in 283 aa overlap);
                     P51659|DHB4_HUMAN|HSD17B4|EDH17B4 ESTRADIOL 17
                     BETA-DEHYDROGENASE (EC 1.1.1.62) from Homo sapiens (Human)
                     (736 aa), FASTA scores: opt: 614, E(): 5.7e-30, (35.9%
                     identity in 284 aa overlap);
                     P97852|DHB4_RAT|HSD17B4|EDH17B4 ESTRADIOL 17
                     BETA-DEHYDROGENASE from Rattus norvegicus (Rat) (735 aa)
                     FASTA scores: opt: 613, E(): 6.6e-30, (37.1% identity in
                     283 aa overlap); Q9DBM3|HSD17B4 ESTRADIOL 17
                     BETA-DEHYDROGENASE from Mus musculus (Mouse) (735 aa)
                     FASTA scores: opt: 611, E(): 8.7e-30, (36.5% identity in
                     285 aa overlap); etc. Also similar to
                     Q11198|Rv3389c|MTV004.47c HYPOTHETICAL 30.3 KDA PROTEIN
                     from Mycobacterium tuberculosis (290 aa), FASTA scores:
                     opt: 609, E(): 5.3e-30, (39.65% identity in 285 aa
                     overlap). Note that previously known as ufaA2. Protein
                     product from Mb3568 detected using SWATH mass
                     spectrometry. Mb3568 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="InterPro:IPR002539"
                     /db_xref="InterPro:IPR029069"
                     /db_xref="InterPro:IPR039569"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y637"
BEGIN
        1 MPIDLDVALG AQLPPVEFSW TSTDVQLYQL GLGAGSDPMN PRELSYLADD TPQVLPTFGN
       61 VAATFHLTTP PTVQFPGIDI ELSKVLHASE RVEVPAPLPP SGSARAVTRF TDIWDKGKAA
      121 VICSETTATT PDGLLLWTQK RSIYARGEGG FGGKRGPSGS DVAPERAPDL QVAMPILPQQ
      181 ALLYRLCGDR NPLHSDPEFA AAAGFPRPIL HGLCTYGMTC KAIVDALLDS DATAVAGYGA
      241 RFAGVAYPGE TLTVNVWKDG RRLVASVVAP TRDNAVVLSG VELVPA
//