LOCUS       SIU02167.1               278 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Amidohydrolase
            family protein protein.
ACCESSION   LT708304-3581
PROTEIN_ID  SIU02167.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3540C"
                     /note="Mb3540c, -, len: 278 aa. Equivalent to Rv3510c,
                     len: 278 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 278 aa overlap). Conserved
                     hypothetical protein, similar to Q50662|Rv2303c|MTCY339.06
                     HYPOTHETICAL 34.6 KDA PROTEIN from Mycobacterium
                     tuberculosis (307 aa), FASTA scores: opt: 416, E():
                     1.2e-19, (35.7% identity in 255 aa overlap). Middle of the
                     putative protein highly similar to N-terminal end of
                     Q49860|B229_C2_182 HYPOTHETICAL 11.0 KDA PROTEIN from
                     Mycobacterium leprae (95 aa), FASTA scores: opt: 304, E():
                     7.9e-13, (83.65% identity in 55 aa overlap). Also some
                     similarity with other bacterial proteins e.g. P95886 ORF
                     C02006 from Sulfolobus solfataricus (269 aa), FASTA
                     scores: opt: 293, E(): 9.6e-12, (31.3% identity in 198 aa
                     overlap); Q9XDF3|NONC NONC PROTEIN from Streptomyces
                     griseus subsp. griseus (317 aa), FASTA scores: opt: 270,
                     E(): 3.4e-10, (29.95% identity in 227 aa overlap);
                     Q54229|NONR MACROTETROLIDE ANTIBIOTIC-RESISTANCE PROTEIN
                     from Streptomyces griseus (347 aa), FASTA scores: opt:
                     270, E(): 3.6e-10, (29.95% identity in 227 aa overlap);
                     etc. Protein product from Mb3540c detected using SWATH
                     mass spectrometry. Mb3540c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y4C3"
                     /db_xref="InterPro:IPR006680"
                     /db_xref="InterPro:IPR032465"
                     /db_xref="InterPro:IPR032466"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y4C3"
BEGIN
        1 MTIDVWMQHP TQRFLHGDMF ASLRRWTGGS IPETDIPIEA TVSSMDAGGV TLGLLSAWRG
       61 PNGQDLISND AVAEWVRLYP NRFAGLAAVD LDRPMAAVRE LRRRVGEGFV GLRVVPWLWG
      121 APPTDRRYYP LFAECVQSAV PFCTQVGHTG PLRPSETGRP IPYIDQVALD FPELVIVCGH
      181 VGYPWTEEMV AVARKHENVY IDTSAYTIKR LPGKLVRFMK TDTGQRKVLF GTNYPMIAHT
      241 HALTGLDELG LSDEARRDFL HGNAVRVFKL DPRGKVQT
//