LOCUS       SIU02142.1               314 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE protein.
ACCESSION   LT708304-3556
PROTEIN_ID  SIU02142.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3515C"
                     /note="Mb3515c, -, len: 314 aa. Equivalent to Rv3485c,
                     len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 314 aa overlap). Probable short-chain
                     dehydrogenase/reductase (EC 1.-.-.-), similar, but longer
                     41 aa, to P71824|Rv0769|MTCY369.14 PUTATIVE SHORT-CHAIN
                     TYPE DEHYDROGENASE/REDUCTASE CY369.14 from Mycobacterium
                     tuberculosis (248 aa), FASTA scores: opt: 462, E():
                     1.8e-19, (34.0% identity in 253 aa overlap). Also similar
                     to various dehydrogenases e.g.
                     P25529|HDHA_ECOLI|HSDH|B1619 NAD-DEPENDENT 7
                     ALPHA-HYDROXYSTEROID DEHYDROGENASE (SDR FAMILY) (EC
                     1.1.1.159) from Escherichia coli strain K12 (alias
                     BAB35750|ECS2327 or AAG56608|HDHA for strain O157:H7) (255
                     aa), FASTA scores: opt: 462, E(): 1.8e-19, (34.7% identity
                     in 248 aa overlap); Q9FD15|RUBG PUTATIVE REDUCTASE (SDR
                     FAMILY) from Streptomyces collinus (249 aa), FASTA scores:
                     opt: 446, E(): 1.5e-18, (36.1% identity in 255 aa
                     overlap); BAB51974|MLL5540 PUTATIVE DEHYDROGENASE from
                     Rhizobium loti (Mesorhizobium loti) (253 aa), FASTA
                     scores: opt: 442, E(): 2.5e-18, (36.25% identity in 251 aa
                     overlap); Q08632|SDR1_PICAB SHORT-CHAIN TYPE
                     DEHYDROGENASE/REDUCTASE (SDR FAMILY) from Picea abies
                     (Norway spruce) (Picea excelsa) (271 aa), FASTA scores:
                     opt: 441, E(): 3.1e-18, (32.3% identity in 260 aa
                     overlap); Q9A326|CC3380 2-DEOXY-D-GLUCONATE
                     3-DEHYDROGENASE from Caulobacter crescentus (260 aa),
                     FASTA scores: opt: 436, E(): 5.7e-18, (32.8% identity in
                     253 aa overlap); Q16698|DECR_HUMAN 2,4-DIENOYL-COA
                     REDUCTASE, MITOCHONDRIAL PRECURSOR (EC 1.3.1.34) from Homo
                     sapiens (Human) (335 aa), FASTA scores: opt: 430, E():
                     1.5e-17, (30.4% identity in 306 aa overlap); etc. Contains
                     short-chain alcohol dehydrogenase family signature
                     (PS00061). BELONGS TO THE SHORT-CHAIN
                     DEHYDROGENASES/REDUCTASES FAMILY (SDR). Protein product
                     from Mb3515c detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb3515c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y4D9"
                     /db_xref="InterPro:IPR002347"
                     /db_xref="InterPro:IPR020904"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y4D9"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MNSRAPRNLA VSSPSAQVTG RMVQNGENLF QFRREGPQVQ LSFQDRTYLV TGGGSGIGKG
       61 VAAGLVAAGA AVMIVGRNPD KLAAAVKDIE ALKTGAIGYE PADITDEEQT LRVVDAATAW
      121 HGRLHGVVHC AGGSQTIGPI TQIDSQAWRR TVDLNVNGTM YVLKHAAREL VRGGGGSFVG
      181 ISSIAASNTH RWFGAYGVTK SAVDHMMKLA ADELGPSWVR VNSIRPGLIR TDLVVPVTES
      241 PELSADYRVC TPLPRVGEVE DVANLAMFLL SDAASWITGQ VINVDGGHML RRGPDFSPML
      301 EPVFGADGLR GVVG
//