LOCUS       SIU02126.1               336 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            4-HYDROXY-2-OXOVALERATE ALDOLASE MHPE (HOA) protein.
ACCESSION   LT708304-3540
PROTEIN_ID  SIU02126.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mhpE"
                     /locus_tag="BQ2027_MB3498C"
                     /note="Mb3498c, mhpE, len: 336 aa. Equivalent to Rv3469c,
                     len: 336 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 336 aa overlap). Probable mhpE,
                     4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.-), similar to
                     others (principally from Pseudomonas species) e.g.
                     Q99PZ1|SCP1.301|SCP1.53c from Streptomyces coelicolor (338
                     aa), FASTA scores: opt: 615, E(): 7.9e-31, (37.65%
                     identity in 332 aa overlap); Q9X9Q0|NIKB NIKB PROTEIN (see
                     first citation below) from Streptomyces tendae (357 aa),
                     FASTA scores: opt: 571, E(): 4.4e-28, (34.5% identity in
                     339 aa overlap); P51014|BPHF_PSES1 from Pseudomonas sp.
                     strain KKS102 (352 aa), FASTA scores: opt: 549, E():
                     9.9e-27, (31.2% identity in 314 aa overlap);
                     Q51983|CMTG_PSEPU from Pseudomonas putida (350 aa), FASTA
                     scores: opt: 543, E(): 2.3e-26, (30.7% identity in 319 aa
                     overlap); P51020|MHPE_ECOLI|MHPF|B0352 from Escherichia
                     coli strain K12 (337 aa), FASTA scores: opt: 517, E():
                     9.1e-25, (31.75% identity in 312 aa overlap); etc. Also
                     similar to P71867|MTCY03C7.22|Rv3534c HYPOTHETICAL 36.4
                     KDA PROTEIN from Mycobacterium tuberculosis (346 aa),
                     FASTA scores: E(): 7.5e-24, (31.9% identity in 310 aa
                     overlap). Mb3498c found to be expressed during exponential
                     growth in Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y4Y7"
                     /db_xref="InterPro:IPR000891"
                     /db_xref="InterPro:IPR013785"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y4Y7"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MLMTATHREP IVLDTTVRDG SYAVNFQYTD DDVRRIVGDL DAAGIPYIEI GHGVTIGAAA
       61 AQGPAAHTDE EYFRAARSVV RNARLGAVIV PALARIETVD LAGDYLDFLR ICVIATEFEL
      121 VMPFVERAQS KGLEVSIQLV KSHLFEPDVL AAAGKRARDV GVRIVYVVDT TGTFLPEDAR
      181 RYVEALRGAS DVSVGFHGHN NLAMAVANTL EAFDAGADFL DGTLMGFGRG AGNCQIECLV
      241 AALQRRGHLA AVDLDRIFDA ARSDMLGRSP QSYGIDPWEI SFGFHGLDSL QVEHLRAAAQ
      301 QAGLSVSHVI RQTAKSHAGQ WLSPQDIDRV VVGMRA
//