LOCUS       SIU02108.1               470 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 esx
            conserved component eccb4. esx-4 type vii secretion system
            protein. probable membrane protein. protein.
ACCESSION   LT708304-3522
PROTEIN_ID  SIU02108.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="eccb4"
                     /locus_tag="BQ2027_MB3480C"
                     /note="Mb3480c, -, len: 470 aa. Equivalent to Rv3450c,
                     len: 470 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 470 aa overlap). Probable conserved
                     membrane protein (possible membrane spanning region near
                     N-terminus). Similar to hypothetical unknowns proteins
                     from Mycobacterium leprae e.g. O33088|MLCB628.17C|ML0054
                     HYPOTHETICAL 51.9 KDA PROTEIN (PUTATIVE MEMBRANE
                     PROTEIN)(481 aa), FASTA scores: opt: 708, E(): 6.4e-32,
                     (32.9% identity in 480 aa overlap); Q9CD29|ML2536 (552
                     aa), FASTA scores: opt: 394, E(): 1.7e-14, (33.6% identity
                     in 503 aa overlap); etc. Also similar to other proteins
                     from Mycobacterium tuberculosis (strains H37Rv and
                     CDC1551) e.g. O69734|Rv3869|MTV027.04 (480 aa), FASTA
                     scores: opt: 717, E(): 2e-32, (32.55% identity in 479 aa
                     overlap); O05449|Rv3895c|MTCY15F10.17 (495 aa), FASTA
                     scores: opt: 670, E(): 8.3e-30, (36.4% identity in 475 aa
                     overlap); O5368|Rv0283|MTV035.11 (538 aa), FASTA scores:
                     opt: 467, E(): 1.5e-18, (36.3% identity in 493 aa
                     overlap); etc. Mb3480c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y4C4"
                     /db_xref="InterPro:IPR007795"
                     /db_xref="InterPro:IPR042485"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y4C4"
BEGIN
        1 MPSPATTWLH VSGYRFLLRR IECALLFGDV CAATGALRAR TTSLALGCVL AIVAAMGCAF
       61 VALLRPQSAL GQAPIVMGRE SGALYVRVDD VWHPVLNLAS ARLIAATNAN PQPVSESELG
      121 HTKRGPLLGI PGAPQLLDQP LAGAESAWAI CDSDNGGSTT VVVGPAEDSS AQVLTAEQMI
      181 LVATESGSPT YLLYGGRRAV VDLADPAVVW ALRLQGRVPH VVAQSLLNAV PEAPRITAPR
      241 IRGGGRASVG LPGFLVGGVV RITRASGDEY YVVLEDGVQR IGQVAADLLR FGDSQGSVNV
      301 PTVAPDVIRV APIVNTLPVS AFPDRPPTPV DGSPGRAVTT LCVTWTPAQP GAARVAFLAG
      361 SGPPVPLGGV PVTLAQADGR GPALDAVYLP PGRSAYVAAR SLSGGGTGTR YLVTDTGVRF
      421 AIHDDDVAHD LGLPTAAIPA PWPVLATLPS GPELSRANAS VARDTVAPGP
//