LOCUS SIU02091.1 473 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 NAD(
P)H-hydrate epimerase (EC / ADP-dependent (S)-NAD(P)H-
hydrate dehydratase (EC protein.
ACCESSION LT708304-3505
PROTEIN_ID SIU02091.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/gene="nnr"
/locus_tag="BQ2027_MB3463C"
/EC_number="5.1.99.6"
/EC_number="4.2.1.136"
/note="Mb3463c, -, len: 473 aa. Equivalent to Rv3433c,
len: 473 aa, from Mycobacterium tuberculosis strain H37Rv,
(99.8% identity in 473 aa overlap). Hypothetical protein,
member of YKL151c/yjeF family, equivalent to
P37391|YY33_MYCLE|ML0373|U229G|B229_C2_201 HYPOTHETICAL
47.2 KDA PROTEIN from Mycobacterium leprae (473 aa), FASTA
scores: opt: 2650, E(): 5e-136, (84.55% identity in 473 aa
overlap). Also similar to other hypothetical bacterial
proteins e.g. Q9X3W3 from Zymomonas mobilis (484 aa),
FASTA scores: opt: 700, E(): 1.2e-30, (33.7% identity in
484 aa overlap); O86783|SC6G4.20c from Streptomyces
coelicolor (485 aa), FASTA scores: opt: 563, E(): 3.2e-23,
(48.45% identity in 489 aa overlap); Q9LC81 from
Arthrobacter sp. Q36 (313 aa), FASTA scores: opt: 553,
E(): 7.9e-23, (44.2% identity in 303 aa overlap); etc.
Contains PS01049 Hypothetical YKL151c/yjeF family
signature 1, PS01050 Hypothetical YKL151c/yjeF family
signature 2. Protein product from Mb3463c detected using
SWATH mass spectrometry. Mb3463c found to be expressed
during exponential growth in Sauton's minimal media by
RNA-sequencing."
/db_xref="GOA:A0A1R3Y479"
/db_xref="InterPro:IPR000631"
/db_xref="InterPro:IPR004443"
/db_xref="InterPro:IPR017953"
/db_xref="InterPro:IPR029056"
/db_xref="InterPro:IPR030677"
/db_xref="InterPro:IPR036652"
/db_xref="UniProtKB/TrEMBL:A0A1R3Y479"
BEGIN
1 MRHYYSVDTI RAAEAPLLAS LPDGALMRRA AFGLATEIGR ELTARTGGVV GRRVCAVVGS
61 GDNGGDALWA ATFLRRRGAA ADAVLLNPDR THRKALAAFT KSGGRLVESV SAATDLVIDG
121 VVGISGSGPL RPAAAQVFAA VQAAAIPVVA VDIPSGIDVA TGAITGPAVH AALTVTFGGL
181 KPVHALADCG RVVLVDIGLD LAHTDVLGFE ATDVAARWPV PGPRDDKYTQ GVTGVLAGSS
241 TYPGAAVLCT GAAVAATSGM VRYAGTAHAE VLAHWPEVIA SPTPAAAGRV QAWVVGPGLG
301 TDEAGAAALW FALDTDLPVL VDADGLTMLA DHPDLVAGRN APTVLTPHAG EFARLAGAPP
361 GDDRVGACRQ LADALGATVL LKGNVTVIAD PGGPVYLNPA GQSWAATAGS GDVLSGMIGA
421 LLASGLPSGE AAAAAAFVHA RAAAAAAADP GPGDAPTSAS RISGHIRAAL AAL
//