LOCUS       SIU02090.1               460 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            GLUTAMATE DECARBOXYLASE GADB protein.
ACCESSION   LT708304-3504
PROTEIN_ID  SIU02090.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="gadB"
                     /locus_tag="BQ2027_MB3462C"
                     /note="Mb3462c, gadB, len: 460 aa. Equivalent to Rv3432c,
                     len: 460 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 460 aa overlap). Probable gadB,
                     glutamate decarboxylase (EC 4.1.1.15), similar to many
                     e.g. P73043|GAD|SLL1641 from Synechocystis sp. strain PCC
                     6803 (467 aa), FASTA scores: opt: 1684, E(): 6.2e-99,
                     (55.35% identity in 457 aa overlap); Q9X8J5|SCE9.23 from
                     Streptomyces coelicolor (475 aa), FASTA scores: opt: 1650,
                     E(): 8.9e-97, (57.4% identity in 446 aa overlap);
                     Q9AQU4|GAD from Oryza sativa (Rice) (501 aa), FASTA
                     scores: opt: 1498, E(): 3.7e-87, (51.6% identity in 432 aa
                     overlap); Q07346|DCE_PETHY from Petunia hybrida (Petunia)
                     (500 aa), FASTA scores: opt: 1485, E(): 2.5e-86, (51.15%
                     identity in 437 aa overlap); etc. BELONGS TO GROUP II
                     DECARBOXYLASES (DDC, GAD, HDC AND TYRDC). Protein product
                     from Mb3462c detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb3462c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y460"
                     /db_xref="InterPro:IPR002129"
                     /db_xref="InterPro:IPR010107"
                     /db_xref="InterPro:IPR015421"
                     /db_xref="InterPro:IPR015424"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y460"
BEGIN
        1 MSRSHPSVPA HSIAPAYTGR MFTAPVPALR MPDESMDPEA AYRFIHDELM LDGSSRLNLA
       61 TFVTTWMDPE AEKLMAETFD KNMIDKDEYP ATAAIEARCV SMVADLFHAE GLRDHDPTSA
      121 TGVSTIGSSE AVMLGGLALK WRWRQRVGSW KGRMPNLVMG SNVQVVWEKF CRYFDVEPRY
      181 LPMERGRYVI TPEQVLAAVD ENTIGVVAIL GTTYTGELEP IAEICAALDK LAAGGGVDVP
      241 VHVDAASGGF VVPFLHPDLV WDFRLPRVVS INVSGHKYGL TYPGVGFVVW RGPEHLPEDL
      301 VFRVNYLGGD MPTFTLNFSR PGNQVVGQYY NFLRLGRDGY TKVMQALSHT ARWLGDQLRE
      361 VDHCEVISDG SAIPVVSFRL AGDRGYTEFD VSHELRTFGW QVPAYTMPDN ATDVAVLRIV
      421 VREGLSADLA RALHDDAVTA LAALDKVKPG GHFDAQHFAH
//