LOCUS       SIU02087.1               178 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 ppe
            family protein ppe57 protein.
ACCESSION   LT708304-3501
PROTEIN_ID  SIU02087.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="PPE57"
                     /locus_tag="BQ2027_MB3459"
                     /note="Mb3459, PPE57, len: 178 aa. Equivalent to 5' end of
                     Rv3425, len: 176 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (90.9% identity in 176 aa overlap). Member
                     of the Mycobacterium tuberculosis PPE family, similar to
                     many e.g. O06246|Rv3429|MTCY77.01 (178 aa), FASTA scores:
                     opt: 781, E(): 7e-44, (69.9% identity in 176 aa overlap);
                     and downstream Q50702|YY26_MYCTU|Rv3426|MTCY78.03c (232
                     aa), FASTA scores: opt: 517, E(): 1.2e-26, (68.0% identity
                     in 125 aa overlap); MTV049_11, MTCY428_16, MTV049_22,
                     MTV049_30, MTCY261_4; etc. Rv3429: Member of the M.
                     tuberculosis PPE family, similar to many e.g. the upstream
                     Q50703|YY25_MYCTU|Rv3425|MTCY78.04c (176 aa), FASTA
                     scores: opt: 781, E(): 1.9e-44, (69.9% identity in 176 aa
                     overlap); and Q50702|YY26_MYCTU|Rv3426|MTCY78.03c (232
                     aa), FASTA scores: opt: 555, E(): 1.7e-29, (72.0% identity
                     in 125 aa overlap) (but diverges at 3' end)); etc.
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a
                     large deletion of 4926 bp (RD6) leads to the loss of the
                     COOH part of PPE57, and the following CDSs, PPE58,
                     Rv3427c, Rv3428c and PPE59 compared to Mycobacterium
                     tuberculosis strain H37Rv. Mb3459 found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="InterPro:IPR000030"
                     /db_xref="InterPro:IPR038332"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y451"
BEGIN
        1 MHPMIPAEYI SNIIYEGPGA DSLFFASGQL RELAYSVETT AESLEDELDE LDENWKGSSS
       61 DLLADAVERY LQWLSKHSSQ LKHAAWVING LANAYNDTRR KVVPPEEIAA NREEVHRLIA
      121 SNVAGVNTPA IAGLDAQYQQ YRAQNIAVMN DYQSTARFIL AYLPRWQEPP QIYGGGGG
//