LOCUS       SIU02085.1               408 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 alanine
            racemase alr protein.
ACCESSION   LT708304-3499
PROTEIN_ID  SIU02085.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="alr"
                     /locus_tag="BQ2027_MB3457C"
                     /note="Mb3457c, alr, len: 408 aa. Equivalent to Rv3423c,
                     len: 408 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 408 aa overlap). Probable alr, alanine
                     racemase (EC 5.1.1.1), equivalent to
                     P38056|ALR_MYCLE|ML0375|B229_C3_243 ALANINE RACEMASE from
                     Mycobacterium leprae (388 aa), FASTA scores: opt: 2160,
                     E(): 2.3e-124, (84.35% identity in 384 aa overlap). Also
                     highly similar to other alanine racemases e.g.
                     Q9L888|ALR_MYCAV from Mycobacterium avium (391 aa), FASTA
                     scores: opt: 2103, E(): 6.8e-121, (83.6% identity in 384
                     aa overlap); P94967|ALR_MYCSM from M. smegmatis (389 aa),
                     FASTA scores: opt: 1721, E(): 1.3e-97, (67.25% identity in
                     385 aa overlap); O86786|ALR_STRCO|SC6G4.23 from
                     Streptomyces coelicolor (391 aa), FASTA scores: opt: 1041,
                     E(): 3.7e-56, (47.65% identity in 380 aa overlap); etc.
                     BELONGS TO THE ALANINE RACEMASE FAMILY. Protein product
                     from Mb3457c detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb3457c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P0A4X3"
                     /db_xref="InterPro:IPR000821"
                     /db_xref="InterPro:IPR001608"
                     /db_xref="InterPro:IPR009006"
                     /db_xref="InterPro:IPR011079"
                     /db_xref="InterPro:IPR020622"
                     /db_xref="InterPro:IPR029066"
                     /db_xref="UniProtKB/Swiss-Prot:P0A4X3"
BEGIN
        1 MKRFWENVGK PNDTTDGRGT TSLAMTPISQ TPGLLAEAMV DLGAIEHNVR VLREHAGHAQ
       61 LMAVVKADGY GHGATRVAQT ALGAGAAELG VATVDEALAL RADGITAPVL AWLHPPGIDF
      121 GPALLADVQV AVSSLRQLDE LLHAVRRTGR TATVTVKVDT GLNRNGVGPA QFPAMLTALR
      181 QAMAEDAVRL RGLMSHMVYA DKPDDSINDV QAQRFTAFLA QAREQGVRFE VAHLSNSSAT
      241 MARPDLTFDL VRPGIAVYGL SPVPALGDMG LVPAMTVKCA VALVKSIRAG EGVSYGHTWI
      301 APRDTNLALL PIGYADGVFR SLGGRLEVLI NGRRCPGVGR ICMDQFMVDL GPGPLDVAEG
      361 DEAILFGPGI RGEPTAQDWA DLVGTIHYEV VTSPRGRITR TYREAENR
//