LOCUS SIU02085.1 408 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 alanine racemase alr protein. ACCESSION LT708304-3499 PROTEIN_ID SIU02085.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="alr" /locus_tag="BQ2027_MB3457C" /note="Mb3457c, alr, len: 408 aa. Equivalent to Rv3423c, len: 408 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 408 aa overlap). Probable alr, alanine racemase (EC 5.1.1.1), equivalent to P38056|ALR_MYCLE|ML0375|B229_C3_243 ALANINE RACEMASE from Mycobacterium leprae (388 aa), FASTA scores: opt: 2160, E(): 2.3e-124, (84.35% identity in 384 aa overlap). Also highly similar to other alanine racemases e.g. Q9L888|ALR_MYCAV from Mycobacterium avium (391 aa), FASTA scores: opt: 2103, E(): 6.8e-121, (83.6% identity in 384 aa overlap); P94967|ALR_MYCSM from M. smegmatis (389 aa), FASTA scores: opt: 1721, E(): 1.3e-97, (67.25% identity in 385 aa overlap); O86786|ALR_STRCO|SC6G4.23 from Streptomyces coelicolor (391 aa), FASTA scores: opt: 1041, E(): 3.7e-56, (47.65% identity in 380 aa overlap); etc. BELONGS TO THE ALANINE RACEMASE FAMILY. Protein product from Mb3457c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb3457c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:P0A4X3" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="UniProtKB/Swiss-Prot:P0A4X3" BEGIN 1 MKRFWENVGK PNDTTDGRGT TSLAMTPISQ TPGLLAEAMV DLGAIEHNVR VLREHAGHAQ 61 LMAVVKADGY GHGATRVAQT ALGAGAAELG VATVDEALAL RADGITAPVL AWLHPPGIDF 121 GPALLADVQV AVSSLRQLDE LLHAVRRTGR TATVTVKVDT GLNRNGVGPA QFPAMLTALR 181 QAMAEDAVRL RGLMSHMVYA DKPDDSINDV QAQRFTAFLA QAREQGVRFE VAHLSNSSAT 241 MARPDLTFDL VRPGIAVYGL SPVPALGDMG LVPAMTVKCA VALVKSIRAG EGVSYGHTWI 301 APRDTNLALL PIGYADGVFR SLGGRLEVLI NGRRCPGVGR ICMDQFMVDL GPGPLDVAEG 361 DEAILFGPGI RGEPTAQDWA DLVGTIHYEV VTSPRGRITR TYREAENR //