LOCUS       SIU02078.1               102 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 transcriptional
            regulatory protein whib-like whib3. contains [4fe-4s]
            cluster. protein.
ACCESSION   LT708304-3492
PROTEIN_ID  SIU02078.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="whiB3"
                     /locus_tag="BQ2027_MB3450"
                     /standard_name="whmB"
                     /note="Mb3450, whiB3, len: 102 aa. Equivalent to Rv3416,
                     len: 102 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 102 aa overlap). whiB3 (alternate gene
                     name: whmB), WhiB-like regulatory protein (see citations
                     below), similar to WhiB paralogue of Streptomyces
                     coelicolor, wblE gene product (85 aa). Equivalent to
                     Q49871|WHIB3|WHIB|ML0382|B229_F1_2|B1620_F3_137 PROBABLE
                     TRANSCRIPTION FACTOR WHIB3 from Mycobacterium leprae (102
                     aa), FASTA scores: opt: 657, E(): 7.9e-39, (86.25%
                     identity in 102 aa overlap). Also highly similar to
                     Q9Z6E9|WHIB3 from Mycobacterium smegmatis (96 aa), FASTA
                     scores: opt: 604, E(): 3.5e-35, (80.4% identity in 102 aa
                     overlap); and O88103|WHID|SC6G4.45c|WBLB from Streptomyces
                     coelicolor (112 aa), FASTA scores: opt: 437, E(): 1.4e-23,
                     (62.5% identity in 96 aa overlap). Also similar to
                     O05847|WHIB1|Rv3219|MTCY07D11.07c from Mycobacterium
                     tuberculosis (84 aa), FASTA scores: opt: 215, E():
                     2.5e-08, (44.45% identity in 81 aa overlap). Note that
                     primer extension analysis revealed three transcriptional
                     start sites and that expression from the three potential
                     promoters is growth phase-dependent (see third citation).
                     Mb3450 found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:Q7TWJ2"
                     /db_xref="InterPro:IPR003482"
                     /db_xref="InterPro:IPR034768"
                     /db_xref="UniProtKB/Swiss-Prot:Q7TWJ2"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MPQPEQLPGP NADIWNWQLQ GLCRGMDSSM FFHPDGERGR ARTQREQRAK EMCRRCPVIE
       61 ACRSHALEVG EPYGVWGGLS ESERDLLLKG TMGRTRGIRR TA
//