LOCUS       SIU02077.1               275 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 CONSERVED
            HYPOTHETICAL PROTEIN protein.
ACCESSION   LT708304-3491
PROTEIN_ID  SIU02077.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3449C"
                     /note="Mb3449c, -, len: 275 aa. Equivalent to Rv3415c,
                     len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 275 aa overlap). Conserved
                     hypothetical protein, equivalent to Q9CCV3|ML0383
                     HYPOTHETICAL PROTEIN from Mycobacterium leprae (281 aa),
                     FASTA scores: opt: 1278, E(): 4.2e-71, (73.5% identity in
                     279 aa overlap); and Q49858|B229_C1_175 HYPOTHETICAL 27.4
                     KDA PROTEIN from Mycobacterium leprae (264 aa), FASTA
                     scores: opt: 1186, E(): 1.7e-65, (74.05% identity in 258
                     aa overlap). And C-terminus highly similar to N-terminal
                     part of Q49726|B1620_C3_232 HYPOTHETICAL 12.9 KDA PROTEIN
                     from Mycobacterium leprae (122 aa), FASTA scores: opt:
                     580, E(): 1.1e-28, (74.6% identity in 126 aa overlap).
                     Also some similarity with
                     P71677|RIBD_MYCTU|RIBG|Rv1409|MT1453|MTCY21B4.26
                     RIBOFLAVIN BIOSYNTHESIS PROTEIN R (339 aa), FASTA scores:
                     opt: 143, E(): 0.13, (28.25% identity in 184 aa overlap).
                     Protein product from Mb3449c detected using SWATH mass
                     spectrometry. Mb3449c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="InterPro:IPR011990"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y441"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MNETPHAPVV EQVLVAAAFG NQPGSWPLPT AITPHHLWLR AVAAGGQGRY AHAYGDLSVL
       61 RRLVPAGPLA SLAHSTQGSL LRQLGWHTLA RGWDGRALAL AGADREAGAD ALIGLAADAL
      121 GVGRFAAAGA LLDRADPLVV SPLVADRLAV RRRWVAAELA MATGDGATAV RHAEEAVELT
      181 QAMAVASARH RVKSDVVLAA ALCSAGAVAR ARAVGEEALD ATARFGLLPL RWALACLLID
      241 IGTVTFSAQQ LRELTKIRNI CAGQVRRAGG CWRTA
//