LOCUS       SIU02071.1               578 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 cholesterol
            oxidase chod (cholesterol-o2 oxidoreductase) protein.
ACCESSION   LT708304-3485
PROTEIN_ID  SIU02071.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="choD"
                     /locus_tag="BQ2027_MB3443C"
                     /note="Mb3443c, choD, len: 578 aa. Equivalent to Rv3409c,
                     len: 578 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 578 aa overlap). Probable choD,
                     cholesterol oxidase precursor (EC 1.1.3.6), equivalent to
                     Q9CCV1|CHOD|ML0389 (alias Q59530|CHOD|B1620_C3_240)
                     PUTATIVE CHOLESTEROL OXIDASE from Mycobacterium leprae
                     (569 aa), FASTA scores: opt: 3510, E(): 3.8e-198, (88.6%
                     identity in 569 aa overlap). Also highly similar to
                     Q9L0H6|SCD63.13 PUTATIVE CHOLESTEROL OXIDASE from
                     Streptomyces coelicolor (602 aa), FASTA scores: opt: 1101,
                     E(): 5.2e-57, (60.05% identity in 586 aa overlap); and
                     similar to other oxidoreductases e.g. Q9A7T6|CC1634
                     OXIDOREDUCTASE (GMC FAMILY) from Caulobacter crescentus
                     (579 aa), FASTA scores: opt: 221, E(): 1.8e-05, (25.2%
                     identity in 583 aa overlap). BELONGS TO THE GMC
                     OXIDOREDUCTASES FAMILY. COFACTOR: FAD FLAVOPROTEIN.
                     Contains PS00017 ATP/GTP-binding site motif A. Protein
                     product from Mb3443c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb3443c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3Y431"
                     /db_xref="InterPro:IPR007867"
                     /db_xref="InterPro:IPR036188"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y431"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MKPDYDVLII GSGFGGSVTA LRLTEKGYRV GVLEAGRRFS DEEFAKTSWD LRKFLWAPRL
       61 GCYGIQRIHP LRNVMILAGA GVGGGSLNYA NTLYVPPEPF FADQQWSHIT DWRGELMPHY
      121 QQAQRMLGVV QNPTFTDADR IVKEVADEMG FGDTWVPTPV GVFFGPDGTK TPGKTVPDPY
      181 FGGAGPARTG CLECGCCMTG CRHGAKNTLV KNYLGLAESA GAQVIPMTTV KGFERRSDGL
      241 WEVRTVRTGS WLRRDRRTFT ATQLVLAAGT WGTQHLLFKM RDRGRLPGLS KRLGVLTRTN
      301 SESIVGAATL KVNPDLDLTH GVAITSSIHP TADTHIEPVR YGKGSNAMGL LQTLMTDGSG
      361 PQGTDVPRWR QLLQTASQDP RGTIRMLNPR QWSERTVIAL VMQHLDNSIT TFTKRGKLGI
      421 RWYSSKQGHG EPNPTWIPIG NQVTRRIAAK IDGVAGGTWG ELFNIPLTAH FLGGAVIGDD
      481 PEHGVIDPYH RVYGYPTLYV VDGAAISANL GVNPSLSIAA QAERAASLWP NKGETDRRPP
      541 QGEPYRRLAP IQPAHPVVPA DAPGALRWLP IDPVSNAG
//