LOCUS SIU02071.1 578 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 cholesterol oxidase chod (cholesterol-o2 oxidoreductase) protein. ACCESSION LT708304-3485 PROTEIN_ID SIU02071.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="choD" /locus_tag="BQ2027_MB3443C" /note="Mb3443c, choD, len: 578 aa. Equivalent to Rv3409c, len: 578 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 578 aa overlap). Probable choD, cholesterol oxidase precursor (EC 1.1.3.6), equivalent to Q9CCV1|CHOD|ML0389 (alias Q59530|CHOD|B1620_C3_240) PUTATIVE CHOLESTEROL OXIDASE from Mycobacterium leprae (569 aa), FASTA scores: opt: 3510, E(): 3.8e-198, (88.6% identity in 569 aa overlap). Also highly similar to Q9L0H6|SCD63.13 PUTATIVE CHOLESTEROL OXIDASE from Streptomyces coelicolor (602 aa), FASTA scores: opt: 1101, E(): 5.2e-57, (60.05% identity in 586 aa overlap); and similar to other oxidoreductases e.g. Q9A7T6|CC1634 OXIDOREDUCTASE (GMC FAMILY) from Caulobacter crescentus (579 aa), FASTA scores: opt: 221, E(): 1.8e-05, (25.2% identity in 583 aa overlap). BELONGS TO THE GMC OXIDOREDUCTASES FAMILY. COFACTOR: FAD FLAVOPROTEIN. Contains PS00017 ATP/GTP-binding site motif A. Protein product from Mb3443c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb3443c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:A0A1R3Y431" /db_xref="InterPro:IPR007867" /db_xref="InterPro:IPR036188" /db_xref="UniProtKB/TrEMBL:A0A1R3Y431" /experiment="experimental evidence, no additional details recorded" BEGIN 1 MKPDYDVLII GSGFGGSVTA LRLTEKGYRV GVLEAGRRFS DEEFAKTSWD LRKFLWAPRL 61 GCYGIQRIHP LRNVMILAGA GVGGGSLNYA NTLYVPPEPF FADQQWSHIT DWRGELMPHY 121 QQAQRMLGVV QNPTFTDADR IVKEVADEMG FGDTWVPTPV GVFFGPDGTK TPGKTVPDPY 181 FGGAGPARTG CLECGCCMTG CRHGAKNTLV KNYLGLAESA GAQVIPMTTV KGFERRSDGL 241 WEVRTVRTGS WLRRDRRTFT ATQLVLAAGT WGTQHLLFKM RDRGRLPGLS KRLGVLTRTN 301 SESIVGAATL KVNPDLDLTH GVAITSSIHP TADTHIEPVR YGKGSNAMGL LQTLMTDGSG 361 PQGTDVPRWR QLLQTASQDP RGTIRMLNPR QWSERTVIAL VMQHLDNSIT TFTKRGKLGI 421 RWYSSKQGHG EPNPTWIPIG NQVTRRIAAK IDGVAGGTWG ELFNIPLTAH FLGGAVIGDD 481 PEHGVIDPYH RVYGYPTLYV VDGAAISANL GVNPSLSIAA QAERAASLWP NKGETDRRPP 541 QGEPYRRLAP IQPAHPVVPA DAPGALRWLP IDPVSNAG //