LOCUS       SIU02059.1               302 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            PHYTOENE SYNTHASE PHYA protein.
ACCESSION   LT708304-3473
PROTEIN_ID  SIU02059.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="phyA"
                     /locus_tag="BQ2027_MB3430C"
                     /standard_name="crtB"
                     /note="Mb3430c, phyA, len: 302 aa. Equivalent to Rv3397c,
                     len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 302 aa overlap). Probable phyA
                     (alternate gene name: crtB), phytoene synthase (EC
                     2.5.1.-), similar to many e.g. Q9X7V5|SC6A5.09 from
                     Streptomyces coelicolor (312 aa), FASTA scores: opt: 791,
                     E(): 2.8e-43, (48.25% identity in 286 aa overlap);
                     Q9RW07|DR0862 from Deinococcus radiodurans (325 aa), FASTA
                     scores: opt: 482, E(): 1.5e-23, (35.25% identity in 292 aa
                     overlap); Q9JRU9|NMB1168|NMB1130 from Neisseria
                     meningitidis (serogroup B) (290 aa), FASTA scores: opt:
                     446, E(): 2.8e-21, (34.25% identity in 260 aa overlap);
                     P37272|PSY_CAPAN from Capsicum annuum (Bell pepper) (419
                     aa), FASTA scores: opt: 431, E(): 3.4e-20, (33.0% identity
                     in 288 aa overlap); etc. Also similar to Q9JUF5|NMA1339
                     PUTATIVE POLY-ISOPRENYL TRANSFERASE (EC 2.5.1.) from
                     Neisseria meningitidis (serogroup A) (290 aa), FASTA
                     scores: opt: 450, E(): 1.6e-21, (34.6% identity in 260 aa
                     overlap). Contains PS01045 Squalene and phytoene synthases
                     signature 2. BELONGS TO THE PHYTOENE/SQUALENE SYNTHETASE
                     FAMILY. Mb3430c found to be expressed during exponential
                     growth in Sauton's minimal media by RNA-sequencing (TPM >
                     20)."
                     /db_xref="GOA:P65861"
                     /db_xref="InterPro:IPR008949"
                     /db_xref="InterPro:IPR017828"
                     /db_xref="InterPro:IPR019845"
                     /db_xref="InterPro:IPR033904"
                     /db_xref="UniProtKB/Swiss-Prot:P65861"
BEGIN
        1 MTEIEQAYRI TESITRTAAR NFYYGIRLLP REKRAALSAV YALGRRIDDV ADGELAPETK
       61 ITELDAIRKS LDNIDDSSDP VLVALADAAR RFPVPIAMFA ELIDGARMEI DWTGCRDFDE
      121 LIVYCRRGAG TIGKLCLSIF GPVSTATSRY AEQLGIALQQ TNILRDVRED FLNGRIYLPR
      181 DELDRLGVRL RLDDTGALDD PDGRLAALLR FSADRAADWY SLGLRLIPHL DRRSAACCAA
      241 MSGIYRRQLA LIRASPAVVY DRRISLSGLK KAQVAAAALA SSVTCGPAHG PLPADLGSHP
      301 SH
//