LOCUS SIU02059.1 302 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE PHYTOENE SYNTHASE PHYA protein. ACCESSION LT708304-3473 PROTEIN_ID SIU02059.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="phyA" /locus_tag="BQ2027_MB3430C" /standard_name="crtB" /note="Mb3430c, phyA, len: 302 aa. Equivalent to Rv3397c, len: 302 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 302 aa overlap). Probable phyA (alternate gene name: crtB), phytoene synthase (EC 2.5.1.-), similar to many e.g. Q9X7V5|SC6A5.09 from Streptomyces coelicolor (312 aa), FASTA scores: opt: 791, E(): 2.8e-43, (48.25% identity in 286 aa overlap); Q9RW07|DR0862 from Deinococcus radiodurans (325 aa), FASTA scores: opt: 482, E(): 1.5e-23, (35.25% identity in 292 aa overlap); Q9JRU9|NMB1168|NMB1130 from Neisseria meningitidis (serogroup B) (290 aa), FASTA scores: opt: 446, E(): 2.8e-21, (34.25% identity in 260 aa overlap); P37272|PSY_CAPAN from Capsicum annuum (Bell pepper) (419 aa), FASTA scores: opt: 431, E(): 3.4e-20, (33.0% identity in 288 aa overlap); etc. Also similar to Q9JUF5|NMA1339 PUTATIVE POLY-ISOPRENYL TRANSFERASE (EC 2.5.1.) from Neisseria meningitidis (serogroup A) (290 aa), FASTA scores: opt: 450, E(): 1.6e-21, (34.6% identity in 260 aa overlap). Contains PS01045 Squalene and phytoene synthases signature 2. BELONGS TO THE PHYTOENE/SQUALENE SYNTHETASE FAMILY. Mb3430c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:P65861" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR017828" /db_xref="InterPro:IPR019845" /db_xref="InterPro:IPR033904" /db_xref="UniProtKB/Swiss-Prot:P65861" BEGIN 1 MTEIEQAYRI TESITRTAAR NFYYGIRLLP REKRAALSAV YALGRRIDDV ADGELAPETK 61 ITELDAIRKS LDNIDDSSDP VLVALADAAR RFPVPIAMFA ELIDGARMEI DWTGCRDFDE 121 LIVYCRRGAG TIGKLCLSIF GPVSTATSRY AEQLGIALQQ TNILRDVRED FLNGRIYLPR 181 DELDRLGVRL RLDDTGALDD PDGRLAALLR FSADRAADWY SLGLRLIPHL DRRSAACCAA 241 MSGIYRRQLA LIRASPAVVY DRRISLSGLK KAQVAAAALA SSVTCGPAHG PLPADLGSHP 301 SH //