LOCUS       SIU02054.1               308 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            NUCLEOSIDE HYDROLASE IUNH (PURINE NUCLEOSIDASE) protein.
ACCESSION   LT708304-3468
PROTEIN_ID  SIU02054.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="iunH"
                     /locus_tag="BQ2027_MB3425"
                     /note="Mb3425, iunH, len: 308 aa. Equivalent to Rv3393,
                     len: 308 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 308 aa overlap). Probable iunH,
                     nucleoside hydrolase (EC 3.2.2.-), similar to others e.g.
                     Q9RXB2|DR0403 from Deinococcus radiodurans (314 aa), FASTA
                     scores: opt: 497, E(): 6e-24, (34.3% identity in 312 aa
                     overlap); Q27546|IUNH_CRIFA from Crithidia fasciculata
                     (314 aa), FASTA scores: opt: 475, E(): 1.4e-22, (31.45%
                     identity in 318 aa overlap); Q9CK67|IUNH from Pasteurella
                     multocida (310 aa), FASTA scores: opt: 464, E(): 6.9e-22,
                     (30.9% identity in 314 aa overlap); Q9A549|CC2615 from
                     Caulobacter crescentus (323 aa), FASTA scores: opt: 464,
                     E(): 7.2e-22, (37.85% identity in 280 aa overlap); etc.
                     Note that also similar to BAB34113|ECS0690 (alias
                     AAG54985|YBEK) PUTATIVE TRNA SYNTHETASE from Escherichia
                     coli strain O157:H7 (311 aa), FASTA scores: opt: 483, E():
                     4.5e-23, (33.0% identity in 315 aa overlap). The active
                     site histidine is conserved. Mb3425 found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y430"
                     /db_xref="InterPro:IPR001910"
                     /db_xref="InterPro:IPR023186"
                     /db_xref="InterPro:IPR036452"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y430"
BEGIN
        1 MSVVFADVDT GIDDALAVIY LLASPDADLV GIASTGGNIA VGQVCANNLS LLELCGAADI
       61 PVSKGADEPL GGRWPDHPKF HGPKGIGYAE LPASNRRLTD YDATTAWIAA AHSHAGDLIG
      121 LVTGPLTNLA LALRAEPALP RLLRRLVIMG GMFDGQPITE WNIRVDPEAA SEVFTAWAGQ
      181 RQLPIVCGLD LTRRVAMTPD ILARLASVCG SSPVMRVIED ALRFYFESHE ARGHGYLAYM
      241 HDPLAAAVAM DPELLTTRTA TVDVDPTGAT VTDWSGKRNP NARIGMSVDP AVFFDRFVER
      301 IGRFARRT
//