LOCUS SIU02051.1 236 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE CONSERVED LIPOPROTEIN LPQD protein. ACCESSION LT708304-3465 PROTEIN_ID SIU02051.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="lpqD" /locus_tag="BQ2027_MB3422" /note="Mb3422, lpqD, len: 236 aa. Equivalent to Rv3390, len: 236 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 236 aa overlap). Probable lpqD, a conserved lipoprotein with some similarity to various bacterial proteins e.g. Q9F3Q7|SC10F4.03 PUTATIVE ISOMERASE from Streptomyces coelicolor (224 aa), FASTA scores: opt: 416, E(): 2.5e-18, (33.0% identity in 197 aa overlap); Q9ZAX0|PGM 2,3-PDG DEPENDENT PHOSPHOGLYCERATE MUTASE from Amycolatopsis methanolica (205 aa), FASTA scores: opt: 314, E(): 3.7e-12, (28.55% identity in 203 aa overlap); P73454|SLR1748 HYPOTHETICAL 24.2 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (214 aa), FASTA scores: opt: 201, E(): 2.8e-05, (23.8% identity in 189 aa overlap); etc. Also similar to Mycobacterium tuberculosis hypothetical proteins e.g. O53817|Rv0754|MTV041.28 PGRS-FAMILY PROTEIN (584 aa), FASTA scores: opt: 219, E(): 5.1e-06, (39.8% identity in 226 aa overlap). Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Protein product from Mb3422 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb3422 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="InterPro:IPR013078" /db_xref="InterPro:IPR029033" /db_xref="UniProtKB/TrEMBL:A0A1R3Y412" BEGIN 1 MAKRTPVRKA CTVLAVLAAT LLLGACGGPT QPRSITLTFI RNAQSQANAD GIIDTDMPGS 61 GLSADGKAEA QQVAHQVSRR DVDSIYSSPM AADQQTAGPL AGELGKQVEI LPGLQAINAG 121 WFNGKPESMA NSTYMLAPAD WLAGDVHNTI PGSISGTEFN SQFSAAVRKI YDSGHNTPVV 181 FSQGVAIMIW TLMNARNSRD SLLTTHPLPN IGRVVITGNP VTGWRLVEWD GIRNFT //