LOCUS       SIU02051.1               236 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CONSERVED LIPOPROTEIN LPQD protein.
ACCESSION   LT708304-3465
PROTEIN_ID  SIU02051.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="lpqD"
                     /locus_tag="BQ2027_MB3422"
                     /note="Mb3422, lpqD, len: 236 aa. Equivalent to Rv3390,
                     len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 236 aa overlap). Probable lpqD, a
                     conserved lipoprotein with some similarity to various
                     bacterial proteins e.g. Q9F3Q7|SC10F4.03 PUTATIVE
                     ISOMERASE from Streptomyces coelicolor (224 aa), FASTA
                     scores: opt: 416, E(): 2.5e-18, (33.0% identity in 197 aa
                     overlap); Q9ZAX0|PGM 2,3-PDG DEPENDENT PHOSPHOGLYCERATE
                     MUTASE from Amycolatopsis methanolica (205 aa), FASTA
                     scores: opt: 314, E(): 3.7e-12, (28.55% identity in 203 aa
                     overlap); P73454|SLR1748 HYPOTHETICAL 24.2 KDA PROTEIN
                     from Synechocystis sp. strain PCC 6803 (214 aa), FASTA
                     scores: opt: 201, E(): 2.8e-05, (23.8% identity in 189 aa
                     overlap); etc. Also similar to Mycobacterium tuberculosis
                     hypothetical proteins e.g. O53817|Rv0754|MTV041.28
                     PGRS-FAMILY PROTEIN (584 aa), FASTA scores: opt: 219, E():
                     5.1e-06, (39.8% identity in 226 aa overlap). Contains
                     signal sequence and appropriately positioned PS00013
                     Prokaryotic membrane lipoprotein lipid attachment site.
                     Protein product from Mb3422 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb3422 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="InterPro:IPR013078"
                     /db_xref="InterPro:IPR029033"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y412"
BEGIN
        1 MAKRTPVRKA CTVLAVLAAT LLLGACGGPT QPRSITLTFI RNAQSQANAD GIIDTDMPGS
       61 GLSADGKAEA QQVAHQVSRR DVDSIYSSPM AADQQTAGPL AGELGKQVEI LPGLQAINAG
      121 WFNGKPESMA NSTYMLAPAD WLAGDVHNTI PGSISGTEFN SQFSAAVRKI YDSGHNTPVV
      181 FSQGVAIMIW TLMNARNSRD SLLTTHPLPN IGRVVITGNP VTGWRLVEWD GIRNFT
//