LOCUS SIU02016.1 123 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE OXIDOREDUCTASE protein. ACCESSION LT708304-3430 PROTEIN_ID SIU02016.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB3387C" /note="Mb3387c, -, len: 123 aa. Equivalent to Rv3352c, len: 123 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 123 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to part of several oxidoreductases (and hypothetical proteins) from diverse organisms e.g. Q9KYD6|SCD72A.20 PUTATIVE LIPOPROTEIN (FRAGMENT) from Streptomyces coelicolor (403 aa), FASTA scores: opt: 348, E(): 7.9e-15, (51.0% identity in 102 aa overlap); BAB53081|MLR6875 PROBABLE OXIDOREDUCTASE from Rhizobium loti (Mesorhizobium loti) (479 aa), FASTA scores: opt: 262, E(): 2.3e-09, (53.85% identity in 78 aa overlap); O94206|OX1 OXIDOREDUCTASE from Claviceps purpurea (Ergot fungus) (483 aa), FASTA scores: opt: 245, E(): 2.7e-08, (42.6% identity in 115 aa overlap); Q9KHK2|ENCM PUTATIVE FAD-DEPENDENT OXYGENASE ENCM from Streptomyces maritimus (464 aa), FASTA scores: opt: 238, E(): 7.2e-08, (43.95% identity in 91 aa overlap); etc. Also highly similar to part of O53608|Rv0063|MTV030.06 OXIDOREDUCTASE (479 aa), FASTA scores: opt: 599, E(): 1.6e-30, (71.55% identity in 123 aa overlap); and to other Mycobacterium tuberculosis proteins e.g. Rv3353c and Rv3351c. All show similarity to a family of oxidoreductases in M. tuberculosis, suggesting that frameshift mutations may have occurred. Sequence has been checked but no errors were found." /db_xref="GOA:A0A1R3Y4P0" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR036318" /db_xref="UniProtKB/TrEMBL:A0A1R3Y4P0" BEGIN 1 MSAATDLYAV HQALAGESRA IPTGSCPTVG VAGLTLGGGL GADSRHAGLT CDALKSATVV 61 LPGGDAVSAS ADDHAELFWA LRGGGGGNFG VTTSMTFARF PTADCDVVRV DFAPSAAAQV 121 LVG //