LOCUS SIU02002.1 379 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE HOMOSERINE O-ACETYLTRANSFERASE META (HOMOSERINE O-TRANS- ACETYLASE) (HOMOSERINE TRANSACETYLASE) (HTA) protein. ACCESSION LT708304-3416 PROTEIN_ID SIU02002.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="metA" /locus_tag="BQ2027_MB3373" /note="Mb3373, metA, len: 379 aa. Equivalent to Rv3341, len: 379 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 379 aa overlap). Probable metA, homoserine o-acetyltransferase (EC 2.3.1.31), equivalent to O32874|METX_MYCLE|META|ML0682|MLCB1779.11 HOMOSERINE O-ACETYLTRANSFERASE from Mycobacterium leprae (382 aa), FASTA scores: opt: 2263, E(): 9.2e-129, (85.0% identity in 380 aa overlap). Also highly similar to many e.g. O68640|METX_CORGL|META from Corynebacterium glutamicum (Brevibacterium flavum) (379 aa), FASTA scores: opt: 1135, E(): 5.9e-61, (48.5% identity in 371 aa overlap); Q9AAS1|CC0525 from Caulobacter crescentus (382 aa), FASTA scores: opt: 860, E(): 2e-44, (40.5% identity in 363 aa overlap); P94891|METX_LEPME from Leptospira meyeri (379 aa), FASTA scores: opt: 787, E(): 4.9e-40, (38.2% identity in 385 aa overlap); etc. BELONGS TO THE AB HYDROLASE FAMILY, HTA SUBFAMILY. Protein product from Mb3373 detected using SWATH mass spectrometry. Mb3373 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:P0A5J9" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR008220" /db_xref="InterPro:IPR029058" /db_xref="UniProtKB/Swiss-Prot:P0A5J9" BEGIN 1 MTISDVPTQT LPAEGEIGLI DVGSLQLESG AVIDDVCIAV QRWGKLSPAR DNVVVVLHAL 61 TGDSHITGPA GPGHPTPGWW DGVAGPGAPI DTTRWCAVAT NVLGGCRGST GPSSLARDGK 121 PWGSRFPLIS IRDQVQADVA ALAALGITEV AAVVGGSMGG ARALEWVVGY PDRVRAGLLL 181 AVGARATADQ IGTQTTQIAA IKADPDWQSG DYHETGRAPD AGLRLARRFA HLTYRGEIEL 241 DTRFANHNQG NEDPTAGGRY AVQSYLEHQG DKLLSRFDAG SYVILTEALN SHDVGRGRGG 301 VSAALRACPV PVVVGGITSD RLYPLRLQQE LADLLPGCAG LRVVESVYGH DGFLVETEAV 361 GELIRQTLGL ADREGACRR //