LOCUS       SIU02002.1               379 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            HOMOSERINE O-ACETYLTRANSFERASE META (HOMOSERINE O-TRANS-
            ACETYLASE) (HOMOSERINE TRANSACETYLASE) (HTA) protein.
ACCESSION   LT708304-3416
PROTEIN_ID  SIU02002.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="metA"
                     /locus_tag="BQ2027_MB3373"
                     /note="Mb3373, metA, len: 379 aa. Equivalent to Rv3341,
                     len: 379 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 379 aa overlap). Probable metA,
                     homoserine o-acetyltransferase (EC 2.3.1.31), equivalent
                     to O32874|METX_MYCLE|META|ML0682|MLCB1779.11 HOMOSERINE
                     O-ACETYLTRANSFERASE from Mycobacterium leprae (382 aa),
                     FASTA scores: opt: 2263, E(): 9.2e-129, (85.0% identity in
                     380 aa overlap). Also highly similar to many e.g.
                     O68640|METX_CORGL|META from Corynebacterium glutamicum
                     (Brevibacterium flavum) (379 aa), FASTA scores: opt: 1135,
                     E(): 5.9e-61, (48.5% identity in 371 aa overlap);
                     Q9AAS1|CC0525 from Caulobacter crescentus (382 aa), FASTA
                     scores: opt: 860, E(): 2e-44, (40.5% identity in 363 aa
                     overlap); P94891|METX_LEPME from Leptospira meyeri (379
                     aa), FASTA scores: opt: 787, E(): 4.9e-40, (38.2% identity
                     in 385 aa overlap); etc. BELONGS TO THE AB HYDROLASE
                     FAMILY, HTA SUBFAMILY. Protein product from Mb3373
                     detected using SWATH mass spectrometry. Mb3373 found to be
                     expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:P0A5J9"
                     /db_xref="InterPro:IPR000073"
                     /db_xref="InterPro:IPR008220"
                     /db_xref="InterPro:IPR029058"
                     /db_xref="UniProtKB/Swiss-Prot:P0A5J9"
BEGIN
        1 MTISDVPTQT LPAEGEIGLI DVGSLQLESG AVIDDVCIAV QRWGKLSPAR DNVVVVLHAL
       61 TGDSHITGPA GPGHPTPGWW DGVAGPGAPI DTTRWCAVAT NVLGGCRGST GPSSLARDGK
      121 PWGSRFPLIS IRDQVQADVA ALAALGITEV AAVVGGSMGG ARALEWVVGY PDRVRAGLLL
      181 AVGARATADQ IGTQTTQIAA IKADPDWQSG DYHETGRAPD AGLRLARRFA HLTYRGEIEL
      241 DTRFANHNQG NEDPTAGGRY AVQSYLEHQG DKLLSRFDAG SYVILTEALN SHDVGRGRGG
      301 VSAALRACPV PVVVGGITSD RLYPLRLQQE LADLLPGCAG LRVVESVYGH DGFLVETEAV
      361 GELIRQTLGL ADREGACRR
//