LOCUS       SIU01993.1               502 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN SUGI protein.
ACCESSION   LT708304-3407
PROTEIN_ID  SIU01993.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="sugI"
                     /locus_tag="BQ2027_MB3364"
                     /note="Mb3364, sugI, len: 502 aa. Equivalent to Rv3331,
                     len: 502 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 502 aa overlap). Probable sugI,
                     sugar-transport integral membrane protein, possibly member
                     of major facilitator superfamily (MFS), similar to several
                     transporters e.g. P37021|GALP_ECOLI|B2943 GALACTOSE-PROTON
                     SYMPORTER (GALACTOSE TRANSPORTER) from Escherichia coli
                     strain K12 (464 aa), FASTA scores: opt: 818, E(): 1.8e-39,
                     (31.85% identity in 446 aa overlap); P96742|YWTG
                     METABOLITE-TRANSPORT-RELATED PROTEIN from Bacillus
                     subtilis (457 aa), FASTA scores: opt: 810, E(): 5e-39,
                     (33.2% identity in 428 aa overlap); AAG58074|GALP (alias
                     BAB37242|ECS3819) GALACTOSE-PROTON SYMPORT OF TRANSPORT
                     SYSTEM from Escherichia coli strain O157:H7 EDL933 (464
                     aa), FASTA scores: opt: 810, E(): 5.1e-39, (32.2% identity
                     in 432 aa overlap); P46333|CSBC_BACSU|SS92BR PROBABLE
                     METABOLITE TRANSPORT PROTEIN from Bacillus subtilis (461
                     aa), FASTA scores: opt: 792, E(): 5.4e-38, (33.7% identity
                     in 442 aa overlap); etc. Equivalent to AAK47777|MT343 from
                     Mycobacterium tuberculosis strain CDC1551 (500 aa) but
                     with some divergence between residues 229 and 254.
                     Contains PS00216 Sugar transport proteins signature 1 and
                     PS00217 Sugar transport proteins signature 2. BELONGS TO
                     THE SUGAR TRANSPORTER FAMILY. Mb3364 found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y3V4"
                     /db_xref="InterPro:IPR003663"
                     /db_xref="InterPro:IPR005828"
                     /db_xref="InterPro:IPR005829"
                     /db_xref="InterPro:IPR020846"
                     /db_xref="InterPro:IPR036259"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y3V4"
BEGIN
        1 MTTLWQPHRN DYSPIPGRGV HARRGARRPR PRGGRAERPG TGQLTRSGRR ALLVGLTAAS
       61 VGVLYGYDLS AIAGALLSLS EEFELTTREQ ELLTTTAVLG QIAGALGGGI LANAIGRKKS
      121 VVLIVAGYAV FALLGATSVS VPMLVVARLL LGVTIGLSVV VVPVYVAESA PAAVRGSLVT
      181 AYQLATLSGI VVGYLVGYLL AGSHGWRAMF GLAAAPATLL LPLLWRMPDT ARWYLLKGRI
      241 ADARSALRRI QPEADIDAEL ADMAAAVDER GGGIGEMVRR PYLRATLFVI ALGFLVQITG
      301 INAIIYYSPR LFAAMGFAGY FAMLALPAMV QVAGLAAVCA SLFLVDRLGR RPILLSGIAT
      361 MITADAVLIT VFANDSDGGT GLVLGFAGVL LFIIGFNFGF GSLVWVYAAE SFPSRLRSMG
      421 SSLMLTSTLT ANAIVAAFSL TMLRVLGGAG VFAVFGTFAV VAFVVVYRFA PETKGRKLEE
      481 IRHFWENGGR WPAERSPAAD EP
//