LOCUS SIU01993.1 502 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN SUGI protein. ACCESSION LT708304-3407 PROTEIN_ID SIU01993.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="sugI" /locus_tag="BQ2027_MB3364" /note="Mb3364, sugI, len: 502 aa. Equivalent to Rv3331, len: 502 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 502 aa overlap). Probable sugI, sugar-transport integral membrane protein, possibly member of major facilitator superfamily (MFS), similar to several transporters e.g. P37021|GALP_ECOLI|B2943 GALACTOSE-PROTON SYMPORTER (GALACTOSE TRANSPORTER) from Escherichia coli strain K12 (464 aa), FASTA scores: opt: 818, E(): 1.8e-39, (31.85% identity in 446 aa overlap); P96742|YWTG METABOLITE-TRANSPORT-RELATED PROTEIN from Bacillus subtilis (457 aa), FASTA scores: opt: 810, E(): 5e-39, (33.2% identity in 428 aa overlap); AAG58074|GALP (alias BAB37242|ECS3819) GALACTOSE-PROTON SYMPORT OF TRANSPORT SYSTEM from Escherichia coli strain O157:H7 EDL933 (464 aa), FASTA scores: opt: 810, E(): 5.1e-39, (32.2% identity in 432 aa overlap); P46333|CSBC_BACSU|SS92BR PROBABLE METABOLITE TRANSPORT PROTEIN from Bacillus subtilis (461 aa), FASTA scores: opt: 792, E(): 5.4e-38, (33.7% identity in 442 aa overlap); etc. Equivalent to AAK47777|MT343 from Mycobacterium tuberculosis strain CDC1551 (500 aa) but with some divergence between residues 229 and 254. Contains PS00216 Sugar transport proteins signature 1 and PS00217 Sugar transport proteins signature 2. BELONGS TO THE SUGAR TRANSPORTER FAMILY. Mb3364 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y3V4" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="UniProtKB/TrEMBL:A0A1R3Y3V4" BEGIN 1 MTTLWQPHRN DYSPIPGRGV HARRGARRPR PRGGRAERPG TGQLTRSGRR ALLVGLTAAS 61 VGVLYGYDLS AIAGALLSLS EEFELTTREQ ELLTTTAVLG QIAGALGGGI LANAIGRKKS 121 VVLIVAGYAV FALLGATSVS VPMLVVARLL LGVTIGLSVV VVPVYVAESA PAAVRGSLVT 181 AYQLATLSGI VVGYLVGYLL AGSHGWRAMF GLAAAPATLL LPLLWRMPDT ARWYLLKGRI 241 ADARSALRRI QPEADIDAEL ADMAAAVDER GGGIGEMVRR PYLRATLFVI ALGFLVQITG 301 INAIIYYSPR LFAAMGFAGY FAMLALPAMV QVAGLAAVCA SLFLVDRLGR RPILLSGIAT 361 MITADAVLIT VFANDSDGGT GLVLGFAGVL LFIIGFNFGF GSLVWVYAAE SFPSRLRSMG 421 SSLMLTSTLT ANAIVAAFSL TMLRVLGGAG VFAVFGTFAV VAFVVVYRFA PETKGRKLEE 481 IRHFWENGGR WPAERSPAAD EP //