LOCUS       SIU01980.1               204 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            METHYLTRANSFERASE protein.
ACCESSION   LT708304-3394
PROTEIN_ID  SIU01980.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3351C"
                     /note="Mb3351c, -, len: 204 aa. Equivalent to Rv3322c,
                     len: 204 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 204 aa overlap). Conserved
                     hypothetical protein, showing weak similarity to proteins
                     including several methyltransferases (EC 2.1.1.-) e.g.
                     Q9X9V1|ORF8 PUTATIVE METHYLTRANSFERASE from Streptomyces
                     coelicolor (208 aa), FASTA scores: opt: 193, E(): 1e-05,
                     (36.35% identity in 132 aa overlap); and Q9XA90|SCF43A.25c
                     PUTATIVE METHYLTRANSFERASE from Streptomyces coelicolor
                     (215 aa), FASTA scores: opt: 161, E(): 0.0014, (32.05%
                     identity in 131 aa overlap); P74712|SLR1183 HYPOTHETICAL
                     21.3 KDA PROTEIN from Synechocystis sp. strain PCC 6803
                     (194 aa), FASTA scores: opt: 155, E(): 0.0032, (27.35%
                     identity in 150 aa overlap); Q9ABW8|CC0102 RRNA
                     METHYLTRANSFERASE RSMB from Caulobacter crescentus (429
                     aa), FASTA scores: opt: 148, E(): 0.018, (31.5% identity
                     in 162 aa overlap); etc. Also highly similar to
                     O05796|Rv3120|MTCY164.30 HYPOTHETICAL 21.8 KDA PROTEIN
                     from Mycobacterium tuberculosis (200 aa), FASTA scores:
                     opt: 691, E(): 1.2e-38, (56.5% identity in 200 aa
                     overlap); and shows weak similarity to
                     O69667|Rv3699|MTV025.047 PUTATIVE METHYLTRANSFERASE from
                     Mycobacterium tuberculosis (233 aa), FASTA scores: opt:
                     155, E(): 0.0037, (29.15% identity in 168 aa overlap).
                     Protein product from Mb3351c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb3351c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y3S8"
                     /db_xref="InterPro:IPR029063"
                     /db_xref="InterPro:IPR041698"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y3S8"
BEGIN
        1 MSVQTDPALR EHPNRVDWNA RYERAGSAHA PFAPVPWLAD VLRAGVPDGP VLELASGRSG
       61 TALALAAHGR QVTAIDVSDV ALLQLDSEAV RRGVADRLNL VQADLGCWEP GETRFALVLS
      121 RLFWDAAIFH RACEAVMPGG VLAWESLALS GAEAGTASAK RRVKPGEPAC LLPADFTVVH
      181 EGQGNCDSAP SRIMIARRSP LPGA
//