LOCUS       SIU01972.1               427 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            THYMIDINE PHOSPHORYLASE DEOA (TDRPASE) (PYRIMIDINE PHOSPHORYLASE)
            protein.
ACCESSION   LT708304-3386
PROTEIN_ID  SIU01972.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="deoA"
                     /locus_tag="BQ2027_MB3343C"
                     /note="Mb3343c, deoA, len: 427 aa. Equivalent to Rv3314c,
                     len: 427 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 427 aa overlap). Probable deoA,
                     thymidine phosporylase (EC 2.4.2.4), highly similar to
                     many e.g. Q9AK36|DEOA from Streptomyces coelicolor (427
                     aa), FASTA scores: opt: 1668, E(): 3.2e-90, (62.35%
                     identity in 425 aa overlap); Q9CFM5|PDP from Lactococcus
                     lactis (subsp. lactis) (Streptococcus lactis) (430 aa),
                     FASTA scores: opt: 1031, E(): 5.5e-53, (46.45% identity in
                     392 aa overlap); P19971|TYPH_HUMAN|ECGF1 from Homo sapiens
                     (Human) (482 aa), FASTA scores: opt: 957, E(): 1.3e-48,
                     (44.45% identity in 441 aa overlap);
                     P07650|TYPH_ECOLI|DEOA|TPP|TTG|B4382 from Escherichia coli
                     strain K12 (440 aa), FASTA scores: opt: 847, E(): 3.2e-42,
                     (41.55% identity in 438 aa overlap); etc. Contains PS00647
                     Thymidine and pyrimidine-nucleoside phosphorylases
                     signature. BELONGS TO THE THYMIDINE/PYRIMIDINE-NUCLEOSIDE
                     PHOSPHORYLASES FAMILY. Protein product from Mb3343c
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb3343c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y3S3"
                     /db_xref="InterPro:IPR000053"
                     /db_xref="InterPro:IPR000312"
                     /db_xref="InterPro:IPR013102"
                     /db_xref="InterPro:IPR017459"
                     /db_xref="InterPro:IPR017872"
                     /db_xref="InterPro:IPR018090"
                     /db_xref="InterPro:IPR035902"
                     /db_xref="InterPro:IPR036320"
                     /db_xref="InterPro:IPR036566"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y3S3"
BEGIN
        1 MTDFAFDAPT VIRTKRDGGR LSDAAIDWVV KAYTDGRVAD EQMSALLMAI VWRGMDRGEI
       61 ARWTAAMLAS GARLDFTDLP LATVDKHSTG GVGDKITLPL VPVVAACGGA VPQASGRGLG
      121 HTGGTLDKLE SITGFTANLS NQRVREQLCD VGAAIFAAGQ LAPADAKLYA LRDITGTVES
      181 LPLIASSIMS KKLAEGAGAL VLDVKVGSGA FMRSPVQARE LAHTMVELGA AHGVPTRALL
      241 TEMNCPLGRT VGNALEVAEA LEVLAGGGPP DVVELTLRLA GEMLELAGIH GRDPAQTLRD
      301 GTAMDRFRWL VAAQGGDLSK PLPIGSHSET VTAGASGTMG DIDAMAVGLA AWRLGAGRSR
      361 PGARVQHGAG VRIHRRPGEP VVVGEPLFTL YTNAPERFGA ARAELAGGWS IRDSPPQVRP
      421 LIVDRIV
//