LOCUS       SIU01971.1               365 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            ADENOSINE DEAMINASE ADD (ADENOSINE AMINOHYDROLASE) protein.
ACCESSION   LT708304-3385
PROTEIN_ID  SIU01971.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="add"
                     /locus_tag="BQ2027_MB3342C"
                     /note="Mb3342c, add, len: 365 aa. Equivalent to Rv3313c,
                     len: 365 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 365 aa overlap). Probable add,
                     adenosine deaminase (EC 3.5.4.4), equivalent to
                     Q9CCL9|ADD|ML0700 PUTATIVE ADENOSINE DEAMINASE from
                     Mycobacterium leprae (362 aa), FASTA scores: opt: 2097,
                     E(): 1.4e-127, (88.2% identity in 356 aa overlap) . Also
                     similar to many e.g. Q9AK25|2SCK8.27 from Streptomyces
                     coelicolor (396 aa), FASTA scores: opt: 1578, E():
                     3.7e-94, (66.65% identity in 360 aa overlap);
                     Q17747|C06G3.5 from Caenorhabditis elegans (349 aa), FASTA
                     scores: opt: 435, E(): 1.1e-20, (29.6% identity in 348 aa
                     overlap); P22333|ADD_ECOLI|B1623 from Escherichia coli
                     strain K12 (333 aa), FASTA scores: opt: 380, E(): 3.7e-17,
                     (29.4% identity in 340 aa overlap); etc. BELONGS TO THE
                     ADENOSINE AND AMP DEAMINASES FAMILY. Protein product from
                     Mb3342c detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb3342c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P63908"
                     /db_xref="InterPro:IPR001365"
                     /db_xref="InterPro:IPR006330"
                     /db_xref="InterPro:IPR028893"
                     /db_xref="InterPro:IPR032466"
                     /db_xref="UniProtKB/Swiss-Prot:P63908"
BEGIN
        1 MTAAPTLQTI RLAPKALLHD HLDGGLRPAT VLDIAGQVGY DDLPATDVDA LASWFRTQSH
       61 SGSLERYLEP FSHTVAVMQT PEALYRVAFE CAQDLAADSV VYAEVRFAPE LHISCGLSFD
      121 DVVDTVLTGF AAGEKACAAD GQPITVRCLV TAMRHAAMSR EIAELAIRFR DKGVVGFDIA
      181 GAEAGHPPTR HLDAFEYMRD HNARFTIHAG EAFGLPSIHE AIAFCGADRL GHGVRIVDDI
      241 DVDADGGFQL GRLAAILRDK RIPLELCPSS NVQTGAVASI AEHPFDLLAR ARFRVTVNTD
      301 NRLMSDTSMS LEMHRLVEAF GYGWSDLARF TVNAMKSAFI PFDQRLAIID EVIKPRFAAL
      361 MGHSE
//